| Title : Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension - Leuillier_2026_Compr.Physiol_16_e70108 |
| Author(s) : Leuillier M , Chelgham M , Messaoudi H , Tu L , Menoret S , Thuillet R , Groussard D , Lillich FF , Ottaviani M , Nicol L , Mulder P , Humbert M , Richard V , Anegon I , Morisseau C , Proschak E , Guignabert C , Bellien J |
| Ref : Compr Physiol , 16 :e70108 , 2026 |
| Abstract : |
| PubMedSearch : Leuillier_2026_Compr.Physiol_16_e70108 |
| PubMedID: 41652841 |
| Title : Fragment-Based Discovery of Fenamic Acids as Pan-Species Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain - Zhu_2026_ACS.Chem.Biol_21_2053 |
| Author(s) : Zhu WF , Feugray G , Brunst S , Messaoudi H , Yang M , Martinez-Conde N , Kramer A , Weizel L , Ehrler JMH , Kramer JS , Kaiser A , Al-Tarrass M , Pereira T , Valet M , Brunel V , Schubert-Zsilavecz M , Knapp S , Lillich FF , Hernandez-Olmos V , Duflot T , Hiesinger K , Qian H , Proschak A , Bellien J , Proschak E |
| Ref : ACS Chemical Biology , 21 :2053 , 2026 |
| Abstract : |
| PubMedSearch : Zhu_2026_ACS.Chem.Biol_21_2053 |
| PubMedID: 42631699 |
| Title : The phosphatase activity of soluble epoxide hydrolase regulates vascular calcification through the metabolism of pyrophosphate anions - Messaoudi_2025_Cell.Death.Dis__ |
| Author(s) : Messaoudi H , Varennes O , Berg E , Perzo N , Renet S , Chegrani G , Duflot T , Feugray G , Lillich FF , Kauffenstein G , Brunel V , Six I , Mentaverri R , Richard V , Anegon I , Morisseau C , Kamel S , Proschak E , Bellien J |
| Ref : Cell Death Dis , : , 2025 |
| Abstract : |
| PubMedSearch : Messaoudi_2025_Cell.Death.Dis__ |
| PubMedID: 41455787 |
| Title : Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells - Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| Author(s) : Brunst S , Schonfeld J , Breunig P , Burgers LD , DeMeglio M , Ehrler JHM , Lillich FF , Weizel L , Hefendehl JK , Furst R , Proschak E , Hiesinger K |
| Ref : ACS Med Chem Lett , 13 :1062 , 2022 |
| Abstract : |
| PubMedSearch : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| PubMedID: 35859883 |
| Title : Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists\/Soluble Epoxide Hydrolase Inhibitors - Lillich_2021_J.Med.Chem_64_17259 |
| Author(s) : Lillich FF , Willems S , Ni X , Kilu W , Borkowsky C , Brodsky M , Kramer JS , Brunst S , Hernandez-Olmos V , Heering J , Schierle S , Kestner RI , Mayser FM , Helmstadter M , Gobel T , Weizel L , Namgaladze D , Kaiser A , Steinhilber D , Pfeilschifter W , Kahnt AS , Proschak A , Chaikuad A , Knapp S , Merk D , Proschak E |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedID: 34818007 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Multi-Target Approaches in Metabolic Syndrome - Lillich_2020_Front.Pharmacol_11_554961 |
| Author(s) : Lillich FF , Imig JD , Proschak E |
| Ref : Front Pharmacol , 11 :554961 , 2020 |
| Abstract : |
| PubMedSearch : Lillich_2020_Front.Pharmacol_11_554961 |
| PubMedID: 33776749 |
| Title : Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain - Kramer_2019_J.Med.Chem_62_8443 |
| Author(s) : Kramer JS , Woltersdorf S , Duflot T , Hiesinger K , Lillich FF , Knoll F , Wittmann SK , Klingler FM , Brunst S , Chaikuad A , Morisseau C , Hammock BD , Buccellati C , Sala A , Rovati GE , Leuillier M , Fraineau S , Rondeaux J , Hernandez-Olmos V , Heering J , Merk D , Pogoryelov D , Steinhilber D , Knapp S , Bellien J , Proschak E |
| Ref : Journal of Medicinal Chemistry , 62 :8443 , 2019 |
| Abstract : |
| PubMedSearch : Kramer_2019_J.Med.Chem_62_8443 |
| PubMedID: 31436984 |