Mather RJ

General

Full name : Mather Robert

First name : Robert

Mail : AstraZeneca

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Country : USA

Email : joe.mather@azneuro.com

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References (5)

Title : Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models - O'Donnell_2010_J.Med.Chem_53_1222
Author(s) : O'Donnell CJ , Rogers BN , Bronk BS , Bryce DK , Coe JW , Cook KK , Duplantier AJ , Evrard E , Hajos M , Hoffmann WE , Hurst RS , Maklad N , Mather RJ , McLean S , Nedza FM , O'Neill BT , Peng L , Qian W , Rottas MM , Sands SB , Schmidt AW , Shrikhande AV , Spracklin DK , Wong DF , Zhang A , Zhang L
Ref : Journal of Medicinal Chemistry , 53 :1222 , 2010
Abstract :
PubMedSearch : O'Donnell_2010_J.Med.Chem_53_1222
PubMedID: 20043678

Title : A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6\/4beta4 nicotinic receptor agonists - Lowe_2010_Bioorg.Med.Chem.Lett_20_4749
Author(s) : Lowe JA, 3rd , DeNinno SL , Coe JW , Zhang L , Mente S , Hurst RS , Mather RJ , Ward KM , Shrikhande A , Rollema H , Johnson DE , Horner W , Gorczyca R , Tingley FD, 3rd , Kozak R , Majchrzak MJ , Tritto T , Sadlier J , Shaffer CL , Ellerbrock B , Osgood SM , MacDougall MC , McDowell LL
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :4749 , 2010
Abstract :
PubMedSearch : Lowe_2010_Bioorg.Med.Chem.Lett_20_4749
PubMedID: 20663668

Title : Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence - Rollema_2010_Br.J.Pharmacol_160_334
Author(s) : Rollema H , Shrikhande A , Ward KM , Tingley FD, 3rd , Coe JW , O'Neill BT , Tseng E , Wang EQ , Mather RJ , Hurst RS , Williams KE , De Vries M , Cremers T , Bertrand S , Bertrand D
Ref : British Journal of Pharmacology , 160 :334 , 2010
Abstract :
PubMedSearch : Rollema_2010_Br.J.Pharmacol_160_334
PubMedID: 20331614

Title : Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists - O'Donnell_2009_Bioorg.Med.Chem.Lett_19_4747
Author(s) : O'Donnell CJ , Peng L , O'Neill BT , Arnold EP , Mather RJ , Sands SB , Shrikhande A , Lebel LA , Spracklin DK , Nedza FM
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4747 , 2009
Abstract :
PubMedSearch : O'Donnell_2009_Bioorg.Med.Chem.Lett_19_4747
PubMedID: 19576766

Title : Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid - Rollema_2007_Neuropharmacol_52_985
Author(s) : Rollema H , Chambers LK , Coe JW , Glowa J , Hurst RS , Lebel LA , Lu Y , Mansbach RS , Mather RJ , Rovetti CC , Sands SB , Schaeffer E , Schulz DW , Tingley FD, 3rd , Williams KE
Ref : Neuropharmacology , 52 :985 , 2007
Abstract :
PubMedSearch : Rollema_2007_Neuropharmacol_52_985
PubMedID: 17157884