Hurst RS

General

Full name : Hurst Raymond S

First name : Raymond S

Mail : Neuroscience Research Unit, Worldwide Research & Development, Pfizer Inc., 700 Main Street, Cambridge, MA 02139, FORUM Pharmaceuticals

Zip Code :

City :

Country : USA

Email : rhurst@forumpharma.com

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Website :

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References (15)

Title : Functional interactions of varenicline and nicotine with nAChR subtypes implicated in cardiovascular control - Rollema_2014_Nicotine.Tob.Res_16_733
Author(s) : Rollema H , Russ C , Lee TC , Hurst RS , Bertrand D
Ref : Nicotine Tob Res , 16 :733 , 2014
Abstract :
PubMedSearch : Rollema_2014_Nicotine.Tob.Res_16_733
PubMedID: 24406270

Title : Nicotinic acetylcholine receptors: from basic science to therapeutics - Hurst_2013_Pharmacol.Ther_137_22
Author(s) : Hurst RS , Rollema H , Bertrand D
Ref : Pharmacol Ther , 137 :22 , 2013
Abstract :
PubMedSearch : Hurst_2013_Pharmacol.Ther_137_22
PubMedID: 22925690

Title : Therapeutic doses of antidepressants are projected not to inhibit human alpha4beta2 nicotinic acetylcholine receptors - Weber_2013_Neuropharmacol_72_88
Author(s) : Weber ML , Hofland CM , Shaffer CL , Flik G , Cremers T , Hurst RS , Rollema H
Ref : Neuropharmacology , 72 :88 , 2013
Abstract :
PubMedSearch : Weber_2013_Neuropharmacol_72_88
PubMedID: 23639435

Title : Partial agonists of the alpha3beta4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats - Chatterjee_2011_Neuropsychopharmacology_36_603
Author(s) : Chatterjee S , Steensland P , Simms JA , Holgate J , Coe JW , Hurst RS , Shaffer CL , Lowe J , Rollema H , Bartlett SE
Ref : Neuropsychopharmacology , 36 :603 , 2011
Abstract :
PubMedSearch : Chatterjee_2011_Neuropsychopharmacology_36_603
PubMedID: 21048701

Title : Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models - O'Donnell_2010_J.Med.Chem_53_1222
Author(s) : O'Donnell CJ , Rogers BN , Bronk BS , Bryce DK , Coe JW , Cook KK , Duplantier AJ , Evrard E , Hajos M , Hoffmann WE , Hurst RS , Maklad N , Mather RJ , McLean S , Nedza FM , O'Neill BT , Peng L , Qian W , Rottas MM , Sands SB , Schmidt AW , Shrikhande AV , Spracklin DK , Wong DF , Zhang A , Zhang L
Ref : Journal of Medicinal Chemistry , 53 :1222 , 2010
Abstract :
PubMedSearch : O'Donnell_2010_J.Med.Chem_53_1222
PubMedID: 20043678

Title : A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6\/4beta4 nicotinic receptor agonists - Lowe_2010_Bioorg.Med.Chem.Lett_20_4749
Author(s) : Lowe JA, 3rd , DeNinno SL , Coe JW , Zhang L , Mente S , Hurst RS , Mather RJ , Ward KM , Shrikhande A , Rollema H , Johnson DE , Horner W , Gorczyca R , Tingley FD, 3rd , Kozak R , Majchrzak MJ , Tritto T , Sadlier J , Shaffer CL , Ellerbrock B , Osgood SM , MacDougall MC , McDowell LL
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :4749 , 2010
Abstract :
PubMedSearch : Lowe_2010_Bioorg.Med.Chem.Lett_20_4749
PubMedID: 20663668

Title : Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence - Rollema_2010_Br.J.Pharmacol_160_334
Author(s) : Rollema H , Shrikhande A , Ward KM , Tingley FD, 3rd , Coe JW , O'Neill BT , Tseng E , Wang EQ , Mather RJ , Hurst RS , Williams KE , De Vries M , Cremers T , Bertrand S , Bertrand D
Ref : British Journal of Pharmacology , 160 :334 , 2010
Abstract :
PubMedSearch : Rollema_2010_Br.J.Pharmacol_160_334
PubMedID: 20331614

Title : Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity - Acker_2008_Bioorg.Med.Chem.Lett_18_3611
Author(s) : Acker BA , Jacobsen EJ , Rogers BN , Wishka DG , Reitz SC , Piotrowski DW , Myers JK , Wolfe ML , Groppi VE , Thornburgh BA , Tinholt PM , Walters RR , Olson BA , Fitzgerald L , Staton BA , Raub TJ , Krause M , Li KS , Hoffmann WE , Hajos M , Hurst RS , Walker DP
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :3611 , 2008
Abstract :
PubMedSearch : Acker_2008_Bioorg.Med.Chem.Lett_18_3611
PubMedID: 18490160

Title : Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid - Rollema_2007_Neuropharmacol_52_985
Author(s) : Rollema H , Chambers LK , Coe JW , Glowa J , Hurst RS , Lebel LA , Lu Y , Mansbach RS , Mather RJ , Rovetti CC , Sands SB , Schaeffer E , Schulz DW , Tingley FD, 3rd , Williams KE
Ref : Neuropharmacology , 52 :985 , 2007
Abstract :
PubMedSearch : Rollema_2007_Neuropharmacol_52_985
PubMedID: 17157884

Title : Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation - Rollema_2007_Trends.Pharmacol.Sci_28_316
Author(s) : Rollema H , Coe JW , Chambers LK , Hurst RS , Stahl SM , Williams KE
Ref : Trends in Pharmacological Sciences , 28 :316 , 2007
Abstract :
PubMedSearch : Rollema_2007_Trends.Pharmacol.Sci_28_316
PubMedID: 17573127

Title : Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists - Walker_2006_Bioorg.Med.Chem_14_8219
Author(s) : Walker DP , Wishka DG , Piotrowski DW , Jia S , Reitz SC , Yates KM , Myers JK , Vetman TN , Margolis BJ , Jacobsen EJ , Acker BA , Groppi VE , Wolfe ML , Thornburgh BA , Tinholt PM , Cortes-Burgos LA , Walters RR , Hester MR , Seest EP , Dolak LA , Han F , Olson BA , Fitzgerald L , Staton BA , Raub TJ , Hajos M , Hoffmann WE , Li KS , Higdon NR , Wall TM , Hurst RS , Wong EH , Rogers BN
Ref : Bioorganic & Medicinal Chemistry , 14 :8219 , 2006
Abstract :
PubMedSearch : Walker_2006_Bioorg.Med.Chem_14_8219
PubMedID: 17011782

Title : Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship - Wishka_2006_J.Med.Chem_49_4425
Author(s) : Wishka DG , Walker DP , Yates KM , Reitz SC , Jia S , Myers JK , Olson KL , Jacobsen EJ , Wolfe ML , Groppi VE , Hanchar AJ , Thornburgh BA , Cortes-Burgos LA , Wong EH , Staton BA , Raub TJ , Higdon NR , Wall TM , Hurst RS , Walters RR , Hoffmann WE , Hajos M , Franklin S , Carey G , Gold LH , Cook KK , Sands SB , Zhao SX , Soglia JR , Kalgutkar AS , Arneric SP , Rogers BN
Ref : Journal of Medicinal Chemistry , 49 :4425 , 2006
Abstract :
PubMedSearch : Wishka_2006_J.Med.Chem_49_4425
PubMedID: 16821801

Title : A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization - Hurst_2005_J.Neurosci_25_4396
Author(s) : Hurst RS , Hajos M , Raggenbass M , Wall TM , Higdon NR , Lawson JA , Rutherford-Root KL , Berkenpas MB , Hoffmann WE , Piotrowski DW , Groppi VE , Allaman G , Ogier R , Bertrand S , Bertrand D , Arneric SP
Ref : Journal of Neuroscience , 25 :4396 , 2005
Abstract :
PubMedSearch : Hurst_2005_J.Neurosci_25_4396
PubMedID: 15858066

Title : Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors - Bodnar_2005_J.Med.Chem_48_905
Author(s) : Bodnar AL , Cortes-Burgos LA , Cook KK , Dinh DM , Groppi VE , Hajos M , Higdon NR , Hoffmann WE , Hurst RS , Myers JK , Rogers BN , Wall TM , Wolfe ML , Wong E
Ref : Journal of Medicinal Chemistry , 48 :905 , 2005
Abstract :
PubMedSearch : Bodnar_2005_J.Med.Chem_48_905
PubMedID: 15715459

Title : High-affinity epibatidine binding of functional, human alpha7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells - Peng_2005_J.Pharmacol.Exp.Ther_313_24
Author(s) : Peng JH , Fryer JD , Hurst RS , Schroeder KM , George AA , Morrissy S , Groppi VE , Leonard SS , Lukas RJ
Ref : Journal of Pharmacology & Experimental Therapeutics , 313 :24 , 2005
Abstract :
PubMedSearch : Peng_2005_J.Pharmacol.Exp.Ther_313_24
PubMedID: 15590768