| Title : Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice - Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| Author(s) : Holladay MW , Bai H , Li Y , Lin NH , Daanen JF , Ryther KB , Wasicak JT , Kincaid JF , He Y , Hettinger AM , Huang P , Anderson DJ , Bannon AW , Buckley MJ , Campbell JE , Donnelly-Roberts D , Gunther KL , Kim DJ , Kuntzweiler TA , Sullivan JP , Decker MW , Arneric SP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2797 , 1998 |
| Abstract : |
| PubMedSearch : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| PubMedID: 9873625 |
| Title : Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors - Holladay_1998_J.Med.Chem_41_407 |
| Author(s) : Holladay MW , Wasicak JT , Lin NH , He Y , Ryther KB , Bannon AW , Buckley MJ , Kim DJ , Decker MW , Anderson DJ , Campbell JE , Kuntzweiler TA , Donnelly-Roberts D , Piattoni-Kaplan M , Briggs CA , Williams M , Arneric SP |
| Ref : Journal of Medicinal Chemistry , 41 :407 , 1998 |
| Abstract : |
| PubMedSearch : Holladay_1998_J.Med.Chem_41_407 |
| PubMedID: 9484491 |
| Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization - Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777 |
| Author(s) : Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Anderson DJ , Campbell JE , Piattoni-Kaplan M , McKenna DG , Wasicak JT , Holladay MW , Williams M , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :777 , 1998 |
| Abstract : |
| PubMedSearch : Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777 |
| PubMedID: 9580626 |
| Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization - Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| Author(s) : Bannon AW , Decker MW , Curzon P , Buckley MJ , Kim DJ , Radek RJ , Lynch JK , Wasicak JT , Lin NH , Arnold WH , Holladay MW , Williams M , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :787 , 1998 |
| Abstract : |
| PubMedSearch : Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| PubMedID: 9580627 |
| Title : Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice - Decker_1998_Eur.J.Pharmacol_346_23 |
| Author(s) : Decker MW , Bannon AW , Buckley MJ , Kim DJ , Holladay MW , Ryther KB , Lin NH , Wasicak JT , Williams M , Arneric SP |
| Ref : European Journal of Pharmacology , 346 :23 , 1998 |
| Abstract : |
| PubMedSearch : Decker_1998_Eur.J.Pharmacol_346_23 |
| PubMedID: 9617748 |
| Title : Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors - Abreo_1996_J.Med.Chem_39_817 |
| Author(s) : Abreo MA , Lin NH , Garvey DS , Gunn DE , Hettinger AM , Wasicak JT , Pavlik PA , Martin YC , Donnelly-Roberts D , Anderson DJ , Sullivan JP , Williams M , Arneric SP , Holladay MW |
| Ref : Journal of Medicinal Chemistry , 39 :817 , 1996 |
| Abstract : |
| PubMedSearch : Abreo_1996_J.Med.Chem_39_817 |
| PubMedID: 8632405 |
| Title : A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand - Sullivan_1996_Neuropharmacol_35_725 |
| Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Piattoni-Kaplan M , Campbell JE , McKenna DG , Molinari E , Hettinger AM , Garvey DS , Wasicak JT , Holladay MW , Williams M , Arneric SP |
| Ref : Neuropharmacology , 35 :725 , 1996 |
| Abstract : |
| PubMedSearch : Sullivan_1996_Neuropharmacol_35_725 |
| PubMedID: 8887981 |
| Title : Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities - |
| Author(s) : Garvey DS , Wasicak JT , Decker MW , Brioni JD , Buckley MJ , Sullivan JP , Carrera GM , Holladay MW , Arneric SP , Williams M |
| Ref : Journal of Medicinal Chemistry , 37 :1055 , 1994 |
| PubMedID: 7909335 |