| Title : Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets - Zhang_2007_Neuropharmacol_52_1095 |
| Author(s) : Zhang D , Saraf A , Kolasa T , Bhatia P , Zheng GZ , Patel M , Lannoye GS , Richardson P , Stewart A , Rogers JC , Brioni JD , Surowy CS |
| Ref : Neuropharmacology , 52 :1095 , 2007 |
| Abstract : Zhang_2007_Neuropharmacol_52_1095 |
| ESTHER : Zhang_2007_Neuropharmacol_52_1095 |
| PubMedSearch : Zhang_2007_Neuropharmacol_52_1095 |
| PubMedID: 17217969 |
| Title : 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction - Kolasa_2006_J.Med.Chem_49_5093 |
| Author(s) : Kolasa T , Matulenko MA , Hakeem AA , Patel MV , Mortell K , Bhatia P , Henry R , Nakane M , Hsieh GC , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino B , El Kouhen O , Marsh KC , Wetter JM , Moreland RB , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 49 :5093 , 2006 |
| Abstract : Kolasa_2006_J.Med.Chem_49_5093 |
| ESTHER : Kolasa_2006_J.Med.Chem_49_5093 |
| PubMedSearch : Kolasa_2006_J.Med.Chem_49_5093 |
| PubMedID: 16913699 |
| Title : Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzam ide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction - Patel_2006_J.Med.Chem_49_7450 |
| Author(s) : Patel MV , Kolasa T , Mortell K , Matulenko MA , Hakeem AA , Rohde JJ , Nelson SL , Cowart MD , Nakane M , Miller LN , Uchic ME , Terranova MA , El-Kouhen OF , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Chang R , Martino BR , Wetter JM , Marsh KC , Martin R , Darbyshire JF , Gintant G , Hsieh GC , Moreland RB , Sullivan JP , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 49 :7450 , 2006 |
| Abstract : Patel_2006_J.Med.Chem_49_7450 |
| ESTHER : Patel_2006_J.Med.Chem_49_7450 |
| PubMedSearch : Patel_2006_J.Med.Chem_49_7450 |
| PubMedID: 17149874 |
| Title : 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist - Nakane_2005_Neuropharmacol_49_112 |
| Author(s) : Nakane M , Cowart MD , Hsieh GC , Miller L , Uchic ME , Chang R , Terranova MA , Donnelly-Roberts D , Namovic MT , Miller TR , Wetter JM , Marsh K , Stewart AO , Brioni JD , Moreland RB |
| Ref : Neuropharmacology , 49 :112 , 2005 |
| Abstract : Nakane_2005_Neuropharmacol_49_112 |
| ESTHER : Nakane_2005_Neuropharmacol_49_112 |
| PubMedSearch : Nakane_2005_Neuropharmacol_49_112 |
| PubMedID: 15992586 |
| Title : Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning - Stewart_2004_J.Med.Chem_47_2348 |
| Author(s) : Stewart AO , Cowart MD , Moreland RB , Latshaw SP , Matulenko MA , Bhatia PA , Wang X , Daanen JF , Nelson SL , Terranova MA , Namovic MT , Donnelly-Roberts D , Miller LN , Nakane M , Sullivan JP , Brioni JD |
| Ref : Journal of Medicinal Chemistry , 47 :2348 , 2004 |
| Abstract : Stewart_2004_J.Med.Chem_47_2348 |
| ESTHER : Stewart_2004_J.Med.Chem_47_2348 |
| PubMedSearch : Stewart_2004_J.Med.Chem_47_2348 |
| PubMedID: 15084133 |
| Title : Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine - Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| Author(s) : Hsieh GC , Hollingsworth PR , Martino B , Chang R , Terranova MA , O'Neill AB , Lynch JJ , Moreland RB , Donnelly-Roberts D , Kolasa T , Mikusa JP , McVey JM , Marsh KC , Sullivan JP , Brioni JD |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :330 , 2004 |
| Abstract : Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| ESTHER : Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| PubMedSearch : Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| PubMedID: 14569075 |
| Title : Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats - Brioni_2004_Proc.Natl.Acad.Sci.U.S.A_101_6758 |
| Author(s) : Brioni JD , Moreland RB , Cowart M , Hsieh GC , Stewart AO , Hedlund P , Donnelly-Roberts D , Nakane M , Lynch JJ, 3rd , Kolasa T , Polakowski JS , Osinski MA , Marsh K , Andersson KE , Sullivan JP |
| Ref : Proc Natl Acad Sci U S A , 101 :6758 , 2004 |
| Abstract : Brioni_2004_Proc.Natl.Acad.Sci.U.S.A_101_6758 |
| ESTHER : Brioni_2004_Proc.Natl.Acad.Sci.U.S.A_101_6758 |
| PubMedSearch : Brioni_2004_Proc.Natl.Acad.Sci.U.S.A_101_6758 |
| PubMedID: 15087502 |
| Title : Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists - Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| Author(s) : Matulenko MA , Hakeem AA , Kolasa T , Nakane M , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Moreland RB , Brioni JD , Stewart AO |
| Ref : Bioorganic & Medicinal Chemistry , 12 :3471 , 2004 |
| Abstract : Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| ESTHER : Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| PubMedSearch : Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| PubMedID: 15186832 |
| Title : Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction - Cowart_2004_J.Med.Chem_47_3853 |
| Author(s) : Cowart M , Latshaw SP , Bhatia P , Daanen JF , Rohde J , Nelson SL , Patel M , Kolasa T , Nakane M , Uchic ME , Miller LN , Terranova MA , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino BR , Lynch JJ, 3rd , Sullivan JP , Hsieh GC , Moreland RB , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 47 :3853 , 2004 |
| Abstract : Cowart_2004_J.Med.Chem_47_3853 |
| ESTHER : Cowart_2004_J.Med.Chem_47_3853 |
| PubMedSearch : Cowart_2004_J.Med.Chem_47_3853 |
| PubMedID: 15239663 |
| Title : Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand - Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| Author(s) : Matulenko MA , Surber B , Fan L , Kolasa T , Nakane M , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Moreland RB , Brioni JD , Stewart AO |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :5095 , 2004 |
| Abstract : Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| ESTHER : Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| PubMedSearch : Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| PubMedID: 15380206 |
| Title : Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5) - Moreland_2004_Biochem.Pharmacol_68_761 |
| Author(s) : Moreland RB , Nakane M , Donnelly-Roberts D , Miller LN , Chang R , Uchic ME , Terranova MA , Gubbins EJ , Helfrich RJ , Namovic MT , El-Kouhen OF , Masters JN , Brioni JD |
| Ref : Biochemical Pharmacology , 68 :761 , 2004 |
| Abstract : Moreland_2004_Biochem.Pharmacol_68_761 |
| ESTHER : Moreland_2004_Biochem.Pharmacol_68_761 |
| PubMedSearch : Moreland_2004_Biochem.Pharmacol_68_761 |
| PubMedID: 15276084 |
| Title : A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors - Gopalakrishnan_2003_Anal.Biochem_321_192 |
| Author(s) : Gopalakrishnan SM , Moreland RB , Kofron JL , Helfrich RJ , Gubbins E , McGowen J , Masters JN , Donnelly-Roberts D , Brioni JD , Burns DJ , Warrior U |
| Ref : Analytical Biochemistry , 321 :192 , 2003 |
| Abstract : Gopalakrishnan_2003_Anal.Biochem_321_192 |
| ESTHER : Gopalakrishnan_2003_Anal.Biochem_321_192 |
| PubMedSearch : Gopalakrishnan_2003_Anal.Biochem_321_192 |
| PubMedID: 14511684 |
| Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP |
| Ref : Pharmacol Biochem Behav , 57 :231 , 1997 |
| Abstract : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| ESTHER : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedSearch : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedID: 9164577 |
| Title : Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties - Lin_1997_J.Med.Chem_40_385 |
| Author(s) : Lin NH , Gunn DE , Ryther KB , Garvey DS , Donnelly-Roberts D , Decker MW , Brioni JD , Buckley MJ , Rodrigues AD , Marsh KG , Anderson DJ , Buccafusco JJ , Prendergast MA , Sullivan JP , Williams M , Arneric SP , Holladay MW |
| Ref : Journal of Medicinal Chemistry , 40 :385 , 1997 |
| Abstract : Lin_1997_J.Med.Chem_40_385 |
| ESTHER : Lin_1997_J.Med.Chem_40_385 |
| PubMedSearch : Lin_1997_J.Med.Chem_40_385 |
| PubMedID: 9022806 |
| Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys - Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| Author(s) : Decker MW , Bannon AW , Curzon P , Gunther KL , Brioni JD , Holladay MW , Lin NH , Li Y , Daanen JF , Buccafusco JJ , Prendergast MA , Jackson WJ , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :247 , 1997 |
| Abstract : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| ESTHER : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedSearch : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedID: 9336330 |
| Title : Cholinergic channel activators: novel opportunities for the treatment of CNS disorders - Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| Author(s) : Sullivan JP , Decker MW , Donnelly-Roberts D , Brioni JD , Bannon AW , Holladay MW , Anderson DJ , Briggs CA , Williams M , Arneric SP |
| Ref : Proc West Pharmacol Soc , 38 :127 , 1995 |
| Abstract : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| ESTHER : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| PubMedSearch : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| PubMedID: 7480004 |
| Title : Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties - Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| Author(s) : Arneric SP , Sullivan JP , Decker MW , Brioni JD , Bannon AW , Briggs CA , Donnelly-Roberts D , Radek RJ , Marsh KC , Kyncl J , Williams M , Buccafusco JJ |
| Ref : Alzheimer Disease & Associated Disorders , 9 Suppl 2 :50 , 1995 |
| Abstract : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| ESTHER : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| PubMedSearch : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| PubMedID: 8534424 |
| Title : Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors - Decker_1995_Eur.J.Pharmacol_280_79 |
| Author(s) : Decker MW , Anderson DJ , Brioni JD , Donnelly-Roberts D , Kang CH , O'Neill AB , Piattoni-Kaplan M , Swanson S , Sullivan JP |
| Ref : European Journal of Pharmacology , 280 :79 , 1995 |
| Abstract : Decker_1995_Eur.J.Pharmacol_280_79 |
| ESTHER : Decker_1995_Eur.J.Pharmacol_280_79 |
| PubMedSearch : Decker_1995_Eur.J.Pharmacol_280_79 |
| PubMedID: 7498257 |
| Title : (+\/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors - Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| Author(s) : Sullivan JP , Decker MW , Brioni JD , Donnelly-Roberts D , Anderson DJ , Bannon AW , Kang CH , Adams P , Piattoni-Kaplan M , Buckley MJ |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 271 :624 , 1994 |
| Abstract : Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| ESTHER : Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| PubMedSearch : Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| PubMedID: 7965777 |
| Title : Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities - |
| Author(s) : Garvey DS , Wasicak JT , Decker MW , Brioni JD , Buckley MJ , Sullivan JP , Carrera GM , Holladay MW , Arneric SP , Williams M |
| Ref : Journal of Medicinal Chemistry , 37 :1055 , 1994 |
| PubMedID: 7909335 |