human-RBBP9

Homo sapiens (Human) Retinoblastoma-binding protein 9 and 10 (rbbp-10) (b5t overexpressed gene protein) (bog protein)

Comment

Retinoblastoma binding protein 9 is an aminopeptidase with a preference for removing aromatic amino acids in human cells (Tang et al.<\/A>) (from OMIM) Woitach et al. (1998) described a new gene, designated BOG (B5T overexpressed gene now RBBP9), which was shown to be overexpressed in several transformed rat liver epithelial cell lines resistant to the growth-inhibitory effect of TGF-beta-1 (TGFB1\; 190180), as well as in primary human liver tumors. The Bog protein was found to share homology with other retinoblastoma-binding proteins and contained the RB1-binding motif LXCXE. Woitach et al. (1998) demonstrated that Bog binds to the RB1 gene product. In vivo, Bog\/Rb complexes do not contain E2F1, and Bog can displace E2F1 from E2F1\/Rb complexes in vitro. Overexpression of Bog in normal RLE cells conferred resistance to the growth-inhibitory effect of TGF-beta-1. Furthermore, normal RLE cells were rapidly transformed when Bog was continuously overexpressed and formed hepatoblastoma-like tumors when transplanted into nude mice. Bog may be important in the transformation process, in part due to its capacity to transfer resistance to the growth-inhibitory effects of TGF-beta-1 through interaction with RB1 and the subsequent displacement of E2F1. Chen et al. (2002) cloned RBBP9, which they called RBBP10. Structure of RBBP9 was determined by Vorobiev et al. 2009. Using an activity-based proteomic approach to identify serine hydrolases in pancreatic cancers, Shields et al. (2010) identified RBBP9. RBBP9 activity, but not expression, was elevated in pancreatic cancers compared with normal tissue. Knockdown of RBBP9 in FG human pancreatic carcinoma cells reduced cell proliferation and altered cell morphology in culture, reduced colony formation in soft agar, and reduced tumor formation in nude mice. Expression of RBBP9 reversed the antiproliferative effect of TGF-beta (TGFB1\; 190180) in FG human pancreatic carcinoma cells and inhibited TGF-beta-dependent SMAD2 (601366)\/SMAD3 (603109) phosphorylation. Mutation of ser75 within a predicted serine hydrolase motif abrogated all RBBP9 activity and functioned as a dominant-negative mutation, permitting unexpectedly elevated TGF-beta activity and SMAD2\/SMAD3 phosphorylation. By yeast 2-hybrid screening of a human fetal brain library using RBBP9 (602908) as bait, Chen et al. (2003) cloned YRDC. The deduced 279-amino acid protein contains a SUA5-YCIO-YRDC domain, a GTP-binding elongation factor signature, and a leucine zipper motif.

Relationship

Family : Hydrolase_RBBP9_YdeN

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

Database

Sequence

Peptide

MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DRLETKLHKF TDCGHFQNTE FHELITVVKS LLKVPA

References (18)

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Author(s) : Tang S , Beattie AT , Kafkova L , Petris G , Huguenin-Dezot N , Fiedler M , Freeman M , Chin JW
Ref : Nature , 602 :701 , 2022
PubMedID: 35173328
Gene_locus related to this paper: human-RBBP9

Title : Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation - Lim_2020_Int.J.Mol.Sci_21_8983
Author(s) : Lim S , Shparberg RA , Coorssen JR , O'Connor MD
Ref : Int J Mol Sci , 21 : , 2020
PubMedID: 33256189
Gene_locus related to this paper: human-RBBP9

Title : Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme - Shenoy_2020_Mol.Pharm_17_1706
Author(s) : Shenoy VM , Thompson BR , Shi J , Zhu HJ , Smith DE , Amidon GL
Ref : Mol Pharm , 17 :1706 , 2020
PubMedID: 32196348
Gene_locus related to this paper: human-RBBP9

Title : Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2 - Adachi_2020_Int.Immunol_32_637
Author(s) : Adachi T , Yasuda K , Muto T , Serada S , Yoshimoto T , Ishii KJ , Kuroda E , Araki K , Ohmuraya M , Naka T , Nakanishi K
Ref : Int Immunol , 32 :637 , 2020
PubMedID: 32484881
Gene_locus related to this paper: human-RBBP9

Title : Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers - Vorobiev_2012_Protein.Pept.Lett_19_194
Author(s) : Vorobiev SM , Huang YJ , Seetharaman J , Xiao R , Acton TB , Montelione GT , Tong L
Ref : Protein Pept Lett , 19 :194 , 2012
PubMedID: 21933118
Gene_locus related to this paper: human-RBBP9

Title : Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9 - Liu_2012_Chembiochem_13_2082
Author(s) : Liu X , Dix M , Speers AE , Bachovchin DA , Zuhl AM , Cravatt BF , Kodadek TJ
Ref : Chembiochem , 13 :2082 , 2012
PubMedID: 22907802
Gene_locus related to this paper: human-RBBP9

Title : Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis - Nachmany_2012_Dis.Markers_32_211
Author(s) : Nachmany H , Wald S , Abekasis M , Bulvik S , Weil M
Ref : Dis Markers , 32 :211 , 2012
PubMedID: 22430187
Gene_locus related to this paper: human-RBBP9

Title : Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance - O'Connor_2011_Exp.Hematol_39_866
Author(s) : O'Connor MD , Wederell E , Robertson G , Delaney A , Morozova O , Poon SS , Yap D , Fee J , Zhao Y , McDonald H , Zeng T , Hirst M , Marra MA , Aparicio SA , Eaves CJ
Ref : Experimental Hematology , 39 :866 , 2011
PubMedID: 21689726
Gene_locus related to this paper: human-RBBP9

Title : Probe Report for RBBP9 Inhibitors - Probe 1 - Brown_2010_Probe.Report__
Author(s) : Brown SJ , Bachovchin DA , Cravatt BF , Fernandez-Vega V , Spicer T , Mercer BA , Hodder P , Rosen HR
Ref : Probe Report , : , 2010
PubMedID: 21433353
Gene_locus related to this paper: human-RBBP9

Title : RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia - Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189
Author(s) : Shields DJ , Niessen S , Murphy EA , Mielgo A , Desgrosellier JS , Lau SK , Barnes LA , Lesperance J , Bouvet M , Tarin D , Cravatt BF , Cheresh DA
Ref : Proc Natl Acad Sci U S A , 107 :2189 , 2010
PubMedID: 20080647
Gene_locus related to this paper: human-RBBP9

Title : Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) - Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254
Author(s) : Bachovchin DA , Wolfe MR , Masuda K , Brown SJ , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2254 , 2010
PubMedID: 20207142
Gene_locus related to this paper: human-RBBP9

Title : Probe Report for RBBP9 Inhibitors - Probe 2 - Bachovchin_2010_Probe.Report.1__
Author(s) : Bachovchin DA , Speers AE , Brown SJ , Cravatt BF , Spicer T , Mercer BA , Ferguson J , Hodder P , Rosen HR
Ref : Probe Report , : , 2010
PubMedID: 21433382
Gene_locus related to this paper: human-RBBP9

Title : Crystal structure of human retinoblastoma binding protein 9 -
Author(s) : Vorobiev SM , Su M , Seetharaman J , Huang YJ , Chen CX , Maglaqui M , Janjua H , Proudfoot M , Yakunin A , Xiao R , Acton TB , Montelione GT , Tong L
Ref : Proteins , 74 :526 , 2009
PubMedID: 19004028
Gene_locus related to this paper: human-RBBP9

Title : Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo - Cassie_2006_Carcinogenesis_27_465
Author(s) : Cassie S , Koturbash I , Hudson D , Baker M , Ilnytskyy Y , Rodriguez-Juarez R , Weber E , Kovalchuk O
Ref : Carcinogenesis , 27 :465 , 2006
PubMedID: 16272168
Gene_locus related to this paper: human-RBBP9

Title : Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10 - Chen_2002_Biochem.Genet_40_273
Author(s) : Chen JZ , Yang QS , Wang S , Meng XF , Ying K , Xie Y , Ma YM
Ref : Biochemical Genetics , 40 :273 , 2002
PubMedID: 12296629
Gene_locus related to this paper: human-RBBP9

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21

Title : The DNA sequence and comparative analysis of human chromosome 20 - Deloukas_2001_Nature_414_865
Author(s) : Deloukas P , Matthews LH , Ashurst J , Burton J , Gilbert JG , Jones M , Stavrides G , Almeida JP , Babbage AK , Bagguley CL , Bailey J , Barlow KF , Bates KN , Beard LM , Beare DM , Beasley OP , Bird CP , Blakey SE , Bridgeman AM , Brown AJ , Buck D , Burrill W , Butler AP , Carder C , Carter NP , Chapman JC , Clamp M , Clark G , Clark LN , Clark SY , Clee CM , Clegg S , Cobley VE , Collier RE , Connor R , Corby NR , Coulson A , Coville GJ , Deadman R , Dhami P , Dunn M , Ellington AG , Frankland JA , Fraser A , French L , Garner P , Grafham DV , Griffiths C , Griffiths MN , Gwilliam R , Hall RE , Hammond S , Harley JL , Heath PD , Ho S , Holden JL , Howden PJ , Huckle E , Hunt AR , Hunt SE , Jekosch K , Johnson CM , Johnson D , Kay MP , Kimberley AM , King A , Knights A , Laird GK , Lawlor S , Lehvaslaiho MH , Leversha M , Lloyd C , Lloyd DM , Lovell JD , Marsh VL , Martin SL , McConnachie LJ , McLay K , McMurray AA , Milne S , Mistry D , Moore MJ , Mullikin JC , Nickerson T , Oliver K , Parker A , Patel R , Pearce TA , Peck AI , Phillimore BJ , Prathalingam SR , Plumb RW , Ramsay H , Rice CM , Ross MT , Scott CE , Sehra HK , Shownkeen R , Sims S , Skuce CD , Smith ML , Soderlund C , Steward CA , Sulston JE , Swann M , Sycamore N , Taylor R , Tee L , Thomas DW , Thorpe A , Tracey A , Tromans AC , Vaudin M , Wall M , Wallis JM , Whitehead SL , Whittaker P , Willey DL , Williams L , Williams SA , Wilming L , Wray PW , Hubbard T , Durbin RM , Bentley DR , Beck S , Rogers J
Ref : Nature , 414 :865 , 2001
PubMedID: 11780052
Gene_locus related to this paper: human-ABHD12 , human-ABHD16B , human-CTSA , human-NDRG3 , human-RBBP9

Title : A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability - Woitach_1998_Nat.Genet_19_371
Author(s) : Woitach JT , Zhang M , Niu CH , Thorgeirsson SS
Ref : Nat Genet , 19 :371 , 1998
PubMedID: 9697699
Gene_locus related to this paper: human-RBBP9 , ratno-rbbp9