PHB
Polyhydroxybutyrate (PHB) is a polyhydroxyalkanoate (PHA thousands of hydroxybutyrate molecules linked end to end) is produced by bacteria (Cupriavidus necator, Ralstonia eutrophus, Methylobacterium rhodesianum or Bacillus megaterium) when nutrients are limited synthetized by PHA synthase phaC. The poly-3-hydroxybutyrate (P3HB)is the most common type, but other polymers are also produced poly-4-hydroxybutyrate (P4HB), polyhydroxyvalerate (PHV), polyhydroxyhexanoate (PHH), polyhydroxyoctanoate (PHO) and their copolymers. They are used as source of bio-derived and biodegradable plastics. || (freom uniprot) PhaC forms a biodegradable plastic that is degraded naturally and completely by bacteria into carbon dioxide and water. Utilized in the medical industry. Plates made from PHA-based plastics can be left in place to help heal fractured bones. After the bone has healed, the plastic slowly breaks down in the body. Utilized by Imperial Chemical Industries (ICI) to produce a PHB-PHV (poly-B-valerate) copolymer sold under the trade name 'Biopol'. Biopol is used as packaging material. The PHB-PHV copolymer consists of approximately 20% PHV and 80% PHB. It can be synthesized by incorporating glucose and valeric acid into the medium. PHB-PHV is stronger and more flexible than regular PHB. Under industrial conditions, 80% or higher of the cell dry weight of A.eutrophus usually consists of the PHB-PHV copolymer
General
Type : Natural, Polymer, Polyhydroxyalkanoate
Chemical_Nomenclature : poly(3-hydroxybutyrate)
Canonical SMILES :
InChI :
InChIKey :
Other name(s) : P(3HB) || P3HB || poly(3-hydroxybutyrate) || polyhydroxybutyrate || acide 3-hydroxybutyrique homopolymer || poly(acide-3-hydroxybutyrique) || C06143
Target
Structures : No structure
Families : Esterase_phb, Esterase_phb_PHAZ, PHAZ7_phb_depolymerase, PolyAspartate-hydrolase, PHB_depolymerase_PhaZ, PHA_synth_I, OHBut_olig_hydro_put
References (12)
| Title : A review on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] and genetic modifications that affect its production - Tang_2022_Front.Bioeng.Biotechnol_10_1057067 |
| Author(s) : Tang HJ , Neoh SZ , Sudesh K |
| Ref : Front Bioeng Biotechnol , 10 :1057067 , 2022 |
| Abstract : |
| PubMedSearch : Tang_2022_Front.Bioeng.Biotechnol_10_1057067 |
| PubMedID: 36545679 |
| Title : Purification, characterization, and gene cloning of an Aspergillus fumigatus polyhydroxybutyrate depolymerase used for degradation of polyhydroxybutyrate, polyethylene succinate, and polybutylene succinate - Jung_2018_Polym.Degrad.Stab_154_186 |
| Author(s) : Jung HW , Yang MK , Su RC |
| Ref : Polymer Degradation and Stability , 154 :154 , 2018 |
| Abstract : |
| PubMedSearch : Jung_2018_Polym.Degrad.Stab_154_186 |
| PubMedID: |
| Gene_locus related to this paper: aspfu-q4w9v8 |
| Title : Production of poly(3-hydroxypropionate) and poly(3-hydroxybutyrate-co-3-hydroxypropionate) from glucose by engineering Escherichia coli - Meng_2015_Metab.Eng_29_189 |
| Author(s) : Meng DC , Wang Y , Wu LP , Shen R , Chen JC , Wu Q , Chen GQ |
| Ref : Metab Eng , 29 :189 , 2015 |
| Abstract : |
| PubMedSearch : Meng_2015_Metab.Eng_29_189 |
| PubMedID: 25842374 |
| Gene_locus related to this paper: alceu-phbc |
| Title : Biochemical analysis and structure determination of Paucimonas lemoignei poly(3-hydroxybutyrate) (PHB) depolymerase PhaZ7 muteins reveal the PHB binding site and details of substrate-enzyme interactions - Jendrossek_2013_Mol.Microbiol_90_649 |
| Author(s) : Jendrossek D , Hermawan S , Subedi B , Papageorgiou AC |
| Ref : Molecular Microbiology , 90 :649 , 2013 |
| Abstract : |
| PubMedSearch : Jendrossek_2013_Mol.Microbiol_90_649 |
| PubMedID: 24007310 |
| Gene_locus related to this paper: psele-PHAZ7 |
| Title : Evaluation of immobilized lipases on poly-hydroxybutyrate beads to catalyze biodiesel synthesis - Mendes_2012_Int.J.Biol.Macromol_50_503 |
| Author(s) : Mendes AA , Oliveira PC , Velez AM , Giordano RC , Giordano Rde L , de Castro HF |
| Ref : Int J Biol Macromol , 50 :503 , 2012 |
| Abstract : |
| PubMedSearch : Mendes_2012_Int.J.Biol.Macromol_50_503 |
| PubMedID: 22285987 |
| Title : The crystal structure of polyhydroxybutyrate depolymerase from Penicillium funiculosum provides insights into the recognition and degradation of biopolyesters - Hisano_2006_J.Mol.Biol_356_993 |
| Author(s) : Hisano T , Kasuya K , Tezuka Y , Ishii N , Kobayashi T , Shiraki M , Oroudjev E , Hansma H , Iwata T , Doi Y , Saito T , Miki K |
| Ref : Journal of Molecular Biology , 356 :993 , 2006 |
| Abstract : |
| PubMedSearch : Hisano_2006_J.Mol.Biol_356_993 |
| PubMedID: 16405909 |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : A novel PHB depolymerase from a thermophilic Streptomyces sp - Calabia_2006_Biotechnol.Lett_28_383 |
| Author(s) : Calabia BP , Tokiwa Y |
| Ref : Biotechnol Lett , 28 :383 , 2006 |
| Abstract : |
| PubMedSearch : Calabia_2006_Biotechnol.Lett_28_383 |
| PubMedID: 16614903 |
| Title : Cutinase-like enzyme from the yeast Cryptococcus sp. strain S-2 hydrolyzes polylactic acid and other biodegradable plastics - Masaki_2005_Appl.Environ.Microbiol_71_7548 |
| Author(s) : Masaki K , Kamini NR , Ikeda H , Iefuji H |
| Ref : Applied Environmental Microbiology , 71 :7548 , 2005 |
| Abstract : |
| PubMedSearch : Masaki_2005_Appl.Environ.Microbiol_71_7548 |
| PubMedID: 16269800 |
| Gene_locus related to this paper: crysp-Q874E9 |
| Title : Repeated batch cultivation of Ralstonia eutropha for Poly (beta-hydroxybutyrate) production - Khanna_2005_Biotechnol.Lett_27_1401 |
| Author(s) : Khanna S , Srivastava AK |
| Ref : Biotechnol Lett , 27 :1401 , 2005 |
| Abstract : |
| PubMedSearch : Khanna_2005_Biotechnol.Lett_27_1401 |
| PubMedID: 16215857 |
| Title : Ralstonia eutropha H16 encodes two and possibly three intracellular Poly[D-(-)-3-hydroxybutyrate] depolymerase genes - York_2003_J.Bacteriol_185_3788 |
| Author(s) : York GM , Lupberger J , Tian J , Lawrence AG , Stubbe J , Sinskey AJ |
| Ref : Journal of Bacteriology , 185 :3788 , 2003 |
| Abstract : |
| PubMedSearch : York_2003_J.Bacteriol_185_3788 |
| PubMedID: 12813072 |
| Gene_locus related to this paper: cupne-q7wt48 , cupne-q7wt49 |
| Title : A new type of thermoalkalophilic hydrolase of Paucimonas lemoignei with high specificity for amorphous polyesters of short chain-length hydroxyalkanoic acids - Handrick_2001_J.Biol.Chem_276_36215 |
| Author(s) : Handrick R , Reinhardt S , Focarete ML , Scandola M , Adamus G , Kowalczuk M , Jendrossek D |
| Ref : Journal of Biological Chemistry , 276 :36215 , 2001 |
| Abstract : |
| PubMedSearch : Handrick_2001_J.Biol.Chem_276_36215 |
| PubMedID: 11457823 |
| Gene_locus related to this paper: psele-PHAZ7 |
| Title : Cloning and characterization of the polyhydroxybutyrate depolymerase gene of Pseudomonas stutzeri and analysis of the function of substrate-binding domains - Ohura_1999_Appl.Environ.Microbiol_65_189 |
| Author(s) : Ohura T , Kasuya KI , Doi Y |
| Ref : Applied Environmental Microbiology , 65 :189 , 1999 |
| Abstract : |
| PubMedSearch : Ohura_1999_Appl.Environ.Microbiol_65_189 |
| PubMedID: 9872779 |
| Gene_locus related to this paper: psesp-PHBDP1 |