human-NDRG4

Homo sapiens (Human) NDRG4, N-myc downstream-regulated gene 4 protein (smap-8) flj42011 flj16174 flj44611

Comment

Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8, SMAP-8 old human-ndr4. A loss-of-function mutation p.T256M in NDRG4 is implicated in the pathogenesis of pulmonary atresia with ventricular septal defect (PA\/VSD) and tetralogy of Fallot (TOF)

Relationship

Family : Ndr_family

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No substrate

No inhibitor

Database

Sequence

Peptide

MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNHKLCFNTF FNFEDMQEIT KHFVVCHVDA PGQQVGASQF PQGYQFPSME QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL AKFALIFPDL VEGLVLVNID PNGKGWIDWA ATKLSGLTST LPDTVLSHLF SQEELVNNTE LVQSYRQQIG NVVNQANLQL FWNMYNSRRD LDINRPGTVP NAKTLRCPVM LVVGDNAPAE DGVVECNSKL DPTTTTFLKM ADSGGLPQVT QPGKLTEAFK YFLQGMGYIA YLKDRRLSGG AVPSASMTRL ARSRTASLTS ASSVDGSRPQ ACTHSESSEG LGQVNHTMEV SC

References (12)

Title : NDRG4 Alleviates Myocardial Infarction-Induced Apoptosis through the JAK2\/STAT3 Pathway - Zhao_2022_Comput.Math.Methods.Med_2022_4869470
Author(s) : Zhao C , Ren Y , Zhang Y
Ref : Comput Math Methods Med , 2022 :4869470 , 2022
PubMedID: 35126626
Gene_locus related to this paper: human-NDRG4

Title : A loss-of-function mutation p.T256M in NDRG4 is implicated in the pathogenesis of pulmonary atresia with ventricular septal defect (PA\/VSD) and tetralogy of Fallot (TOF) - Peng_2021_FEBS.Open.Bio_11_375
Author(s) : Peng J , Wang Q , Meng Z , Wang J , Zhou Y , Zhou S , Song W , Chen S , Chen AF , Sun K
Ref : FEBS Open Bio , 11 :375 , 2021
PubMedID: 33211401
Gene_locus related to this paper: human-NDRG4

Title : Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis - Yang_2021_Med.Sci.Monit_27_e928523
Author(s) : Yang Z , Cheng H , Zhang Y , Zhou Y
Ref : Med Sci Monit , 27 :e928523 , 2021
PubMedID: 33667214
Gene_locus related to this paper: human-NDRG4

Title : Hypermethylation-mediated silencing of NDRG4 promotes pancreatic ductal adenocarcinoma by regulating mitochondrial function - Shi_2020_BMB.Rep_53_658
Author(s) : Shi HH , Liu HE , Luo XJ
Ref : BMB Rep , 53 :658 , 2020
PubMedID: 33298240
Gene_locus related to this paper: human-NDRG4

Title : Exome sequencing identifies a novel homozygous variant in NDRG4 in a family with infantile myofibromatosis (Linhares et al., 2014) turns out to be EBV+ leiomyomatosis caused by CARMIL2 mutations -
Author(s) : Linhares ND , Freire MCM , Cardenas R , Pena HB , Bahia M , Pena SDJ
Ref : Eur Journal of Medical Genetics , 61 :106 , 2018
PubMedID: 28223207
Gene_locus related to this paper: human-NDRG4

Title : Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing - Yang_2016_Cell_164_805
Author(s) : Yang X , Coulombe-Huntington J , Kang S , Sheynkman GM , Hao T , Richardson A , Sun S , Yang F , Shen YA , Murray RR , Spirohn K , Begg BE , Duran-Frigola M , MacWilliams A , Pevzner SJ , Zhong Q , Trigg SA , Tam S , Ghamsari L , Sahni N , Yi S , Rodriguez MD , Balcha D , Tan G , Costanzo M , Andrews B , Boone C , Zhou XJ , Salehi-Ashtiani K , Charloteaux B , Chen AA , Calderwood MA , Aloy P , Roth FP , Hill DE , Iakoucheva LM , Xia Y , Vidal M
Ref : Cell , 164 :805 , 2016
PubMedID: 26871637
Gene_locus related to this paper: human-NDRG4

Title : Exome sequencing identifies a novel homozygous variant in NDRG4 in a family with infantile myofibromatosis - Linhares_2014_Eur.J.Med.Genet_57_643
Author(s) : Linhares ND , Freire MC , Cardenas RG , Pena HB , Bahia M , Pena SD
Ref : Eur Journal of Medical Genetics , 57 :643 , 2014
PubMedID: 25241110
Gene_locus related to this paper: human-NDRG4

Title : Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family - Qu_2002_Mol.Cell.Biochem_229_35
Author(s) : Qu X , Zhai Y , Wei H , Zhang C , Xing G , Yu Y , He F
Ref : Molecular & Cellular Biochemistry , 229 :35 , 2002
PubMedID: 11936845
Gene_locus related to this paper: human-NDRG1 , human-NDRG2 , human-NDRG3 , human-NDRG4

Title : Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones - Nakajima_2002_DNA.Res_9_99
Author(s) : Nakajima D , Okazaki N , Yamakawa H , Kikuno R , Ohara O , Nagase T
Ref : DNA Research , 9 :99 , 2002
PubMedID: 12168954
Gene_locus related to this paper: human-NDRG4

Title : Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs - Wiemann_2001_Genome.Res_11_422
Author(s) : Wiemann S , Weil B , Wellenreuther R , Gassenhuber J , Glassl S , Ansorge W , Boecher M , Bloecker H , Bauersachs S , Blum H , Lauber J , Duesterhoeft A , Beyer A , Koehrer K , Strack N , Mewes H-W , Ottenwaelder B , Obermaier B , Tampe J , Heubner D , Wambutt R , Korn B , Klein M , Poustka A , Bocher M , Blocker H , Dusterhoft A , Kohrer K , Mewes HW , Ottenwalder B
Ref : Genome Res , 11 :422 , 2001
PubMedID: 11230166
Gene_locus related to this paper: human-FAM135A , human-KANSL3 , human-NDRG2 , human-NDRG4

Title : Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart - Zhou_2001_Genomics_73_86
Author(s) : Zhou RH , Kokame K , Tsukamoto Y , Yutani C , Kato H , Miyata T
Ref : Genomics , 73 :86 , 2001
PubMedID: 11352569
Gene_locus related to this paper: human-NDRG2 , human-NDRG3 , human-NDRG4

Title : Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain - Hirosawa_1999_DNA.Res_6_329
Author(s) : Hirosawa M , Nagase T , Ishikawa K-I , Kikuno R , Nomura N , Ohara O , Ishikawa K
Ref : DNA Research , 6 :329 , 1999
PubMedID: 10574461
Gene_locus related to this paper: human-NDRG4