Ndr_family

Relationship

Family: Ndr_family

Block: X

Parent Family: No family

Comment

RTP/Drg1/Ndr1 genes are repressed by the proto-oncogenes N-myc and c-myc. Members of this family are found in wide variety of multicellular eukaryotes, including plants (ndr nothing to do with nodal-related genes) Ndr1 included in alpha/beta hydolase PF00561 now have a Pfam family PF03096. Shaw et al Proteins 2002 May 1;47(2):163-8 identified this family as alpha/beta hydrolase. Kalaydjieva et al. showed that human-NDRG1 is mutated in hereditary motor and sensory neuropathy-Lom. Bhaduri et al. showed that ratno-ndr4 (Bdm1) is associated with hot water epilepsy. Mitchelmore et al. showed that NDRG2 is upregulated in Alzheimer's disease. NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase as published by Dong et al. (obsolete subfamilies IPR030693 Protein NDRG1; IPR030690 Protein NDRG2; IPR030692 Protein NDRG3; IPR030695 Protein NDRG4)

Database

Interpro : IPR004142 NDRG

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF03096 Ndr

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (8)

Genes Proteins in Ndr_family family (258)

Fragments of genes in Ndr_family family (57)

Structures in Ndr_family family (8)

No substrate

No Inhibitor

References (14)

Title : A review on the role of NDRG1 in different cancers - Ghafouri-Fard_2023_Mol.Biol.Rep__
Author(s) : Ghafouri-Fard S , Ahmadi Teshnizi S , Hussen BM , Taheri M , Sharifi G
Ref : Mol Biol Rep , : , 2023
PubMedID: 37249826
Gene_locus related to this paper: human-NDRG1

Title : Prognostic and biological role of the N-Myc downstream-regulated gene family in hepatocellular carcinoma - Yin_2022_World.J.Clin.Cases_10_2072
Author(s) : Yin X , Yu H , He XK , Yan SX
Ref : World J Clin Cases , 10 :2072 , 2022
PubMedID: 35321174

Title : Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family - Le_2021_FASEB.J_35_e21961
Author(s) : Le N , Hufford TM , Park JS , Brewster RM
Ref : FASEB Journal , 35 :e21961 , 2021
PubMedID: 34665878

Title : Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D - Skedsmo_2021_Neuromuscul.Disord_31_56
Author(s) : Skedsmo FS , Espenes A , Tranulis MA , Matiasek K , Gunnes G , Bjerkas I , Moe L , Roed SS , Berendt M , Fredholm M , Rohdin C , Shelton GD , Bruheim P , Stafsnes MH , Bartosova Z , Hermansen LC , Stigen , Jaderlund KH
Ref : Neuromuscular Disorders , 31 :56 , 2021
PubMedID: 33334662

Title : The Role of N-myc Downstream-Regulated Gene Family in Glioma Based on Bioinformatics Analysis - Tang_2021_DNA.Cell.Biol_40_949
Author(s) : Tang T , Wang H , Han Y , Huang H , Niu W , Fei M , Zhu Y
Ref : DNA & Cell Biology , 40 :949 , 2021
PubMedID: 34115542

Title : NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase - Dong_2021_PLoS.Pathog_17_e1009645
Author(s) : Dong L , Dong J , Xiang M , Lei P , Li Z , Zhang F , Sun X , Niu D , Bai L , Lan K
Ref : PLoS Pathog , 17 :e1009645 , 2021
PubMedID: 34077484
Gene_locus related to this paper: human-NDRG1

Title : The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways. - Kovacevic_2013_Antioxid.Redox.Signal_18_874
Author(s) : Kovacevic Z , Chikhani S , Lui GY , Sivagurunathan S , Richardson DR
Ref : Antioxid Redox Signal , 18 :874 , 2013
PubMedID: 22462691

Title : NDRG2 and PRA1 interact and synergistically inhibit T-cell factor\/beta-catenin signaling. - Kim_2012_FEBS.Lett_586_3962
Author(s) : Kim JT , Kim JW , Kang YH , Kim KD , Lee SJ , Choi SC , Kim KS , Chae SK , Lim JS , Lee HG
Ref : FEBS Letters , 586 :3962 , 2012
PubMedID: 23068607

Title : Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor - Hwang_2011_J.Biol.Chem_286_12450
Author(s) : Hwang J , Kim Y , Kang HB , Jaroszewski L , Deacon AM , Lee H , Choi WC , Kim KJ , Kim CH , Kang BS , Lee JO , Oh TK , Kim JW , Wilson IA , Kim MH
Ref : Journal of Biological Chemistry , 286 :12450 , 2011
PubMedID: 21247902
Gene_locus related to this paper: human-NDRG2

Title : The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications - Melotte_2010_FASEB.J_24_4153
Author(s) : Melotte V , Qu X , Ongenaert M , Van Criekinge W , de Bruine AP , Baldwin HS , van Engeland M
Ref : FASEB Journal , 24 :4153 , 2010
PubMedID: 20667976

Title : NDRG2: a novel Alzheimer's disease associated protein - Mitchelmore_2004_Neurobiol.Dis_16_48
Author(s) : Mitchelmore C , Buchmann-Moller S , Rask L , West MJ , Troncoso JC , Jensen NA
Ref : Neurobiol Dis , 16 :48 , 2004
PubMedID: 15207261
Gene_locus related to this paper: human-NDRG2

Title : Fold prediction and comparative modeling of Bdm1: a probable alpha\/beta hydrolase associated with hot water epilepsy - Bhaduri_2003_J.Mol.Model_9_3
Author(s) : Bhaduri A , Krishnaswamy L , Ullal GR , Panicker MM , Sowdhamini R
Ref : J Mol Model , 9 :3 , 2003
PubMedID: 12638006
Gene_locus related to this paper: ratno-ndr4

Title : Identification of a novel class in the alpha\/beta hydrolase fold superfamily: the N-myc differentiation-related proteins - Shaw_2002_Proteins_47_163
Author(s) : Shaw E , McCue LA , Lawrence CE , Dordick JS
Ref : Proteins , 47 :163 , 2002
PubMedID: 11933063

Title : N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom - Kalaydjieva_2000_Am.J.Hum.Genet_67_47
Author(s) : Kalaydjieva L , Gresham D , Gooding R , Heather L , Baas F , de Jonge R , Blechschmidt K , Angelicheva D , Chandler D , Worsley P , Rosenthal A , King RH , Thomas PK
Ref : American Journal of Human Genetics , 67 :47 , 2000
PubMedID: 10831399
Gene_locus related to this paper: human-NDRG1