human-NDRG3
Homo sapiens (Human) ndrg3 protein ndr1-related development protein ndr3 otthump00000030883 otthump00000030882
Comment
old human-ndr3 || Q96SM2 alternative splicing || NDRG3 regulates imatinib resistance by promoting catenin accumulation in the nucleus in chronic myelogenous leukemia . (Wang 2023)NDRG3 interacts with K-RAS (5small GTPase) and USP9X (deubiquitinating enzyme) and leads to deubiquitination of KRAS protein. KRAS-driven cancer development critically depends on its deubiquitination Koo 2025
Relationship
Family : Ndr_family
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
No mutation
No kinetic
No disease
No substrate
No inhibitor
Database
Sequence
Peptide
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QGHDIETTHG VVHVTIRGLP KGNRPVILTY HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG APSFPTGYQY PTMDELAEML PPVLTHLSLK SIIGIGVGAG AYILSRFALN HPELVEGLVL INVDPCAKGW IDWAASKLSG LTTNVVDIIL AHHFGQEELQ ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP ILGQNDNKSK TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN QSDGTQESCE SPDVLDRHQT MEVSC
References (26)
| Title : Anti-proteolytic regulation of KRAS by USP9X\/NDRG3 in KRAS-driven cancer development - Koo_2025_Nat.Commun_16_628 |
| Author(s) : Koo H , Park KC , Sohn HA , Kang M , Kim DJ , Park ZY , Park S , Min SH , Park SH , You YM , Han Y , Kim BK , Lee CH , Kim YS , Chung SJ , Yeom YI , Lee DC |
| Ref : Nat Commun , 16 :628 , 2025 |
| Abstract : |
| PubMedSearch : Koo_2025_Nat.Commun_16_628 |
| PubMedID: 39819877 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : NDRG3 regulates imatinib resistance by promoting betacatenin accumulation in the nucleus in chronic myelogenous leukemia - Wang_2023_Oncol.Rep_50_152 |
| Author(s) : Wang X , Rong S , Sun Y , Yin B , Yang X , Lu X , Sun H , Yan Y , Sun G , Liang Y , Wang P , Xie S , Li Y |
| Ref : Oncol Rep , 50 :152 , 2023 |
| Abstract : |
| PubMedSearch : Wang_2023_Oncol.Rep_50_152 |
| PubMedID: 37350410 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners - Xu_2023_J.Biol.Chem_299_104802 |
| Author(s) : Xu Y , Kusuyama J , Osana S , Matsuhashi S , Li L , Takada H , Inada H , Nagatomi R |
| Ref : Journal of Biological Chemistry , 299 :104802 , 2023 |
| Abstract : |
| PubMedSearch : Xu_2023_J.Biol.Chem_299_104802 |
| PubMedID: 37172727 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers - Sohn_2022_Cells_11_ |
| Author(s) : Sohn HA , Lee DC , Park A , Kang M , Yoon BH , Lee CH , Kim YH , Oh KJ , Kim CY , Park SH , Koo H , Kim HC , Yoon WK , Lim DS , Kim D , Park KC , Yeom YI |
| Ref : Cells , 11 : , 2022 |
| Abstract : |
| PubMedSearch : Sohn_2022_Cells_11_ |
| PubMedID: 35563842 |
| Gene_locus related to this paper: human-NDRG3 , mouse-ndr3 |
| Title : High expression of NDRG3 correlates with poor prognosis in gastric cancer patients - Liu_2021_Rev.Esp.Enferm.Dig_113_524 |
| Author(s) : Liu Y , Xia J , Zhou Y , Shao S |
| Ref : Rev Esp Enferm Dig , 113 :524 , 2021 |
| Abstract : |
| PubMedSearch : Liu_2021_Rev.Esp.Enferm.Dig_113_524 |
| PubMedID: 33562989 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : The LINC01410\/miR-122-5p\/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells - Ma_2021_IUBMB.Life_73_705 |
| Author(s) : Ma W , Zhao X , Xue N , Gao Y , Xu Q |
| Ref : IUBMB Life , 73 :705 , 2021 |
| Abstract : |
| PubMedSearch : Ma_2021_IUBMB.Life_73_705 |
| PubMedID: 33583123 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein - Kim_2020_Biomolecules_10_ |
| Author(s) : Kim KR , Kim KA , Park JS , Jang JY , Choi Y , Lee HH , Lee DC , Park KC , Yeom YI , Kim HJ , Han BW |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : Kim_2020_Biomolecules_10_ |
| PubMedID: 31935861 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : SNHG20\/miR-140-5p\/NDRG3 axis contributes to 5-fluorouracil resistance in gastric cancer - Yu_2019_Oncol.Lett_18_1337 |
| Author(s) : Yu J , Shen J , Qiao X , Cao L , Yang Z , Ye H , Xi C , Zhou Q , Wang P , Gong Z |
| Ref : Oncol Lett , 18 :1337 , 2019 |
| Abstract : |
| PubMedSearch : Yu_2019_Oncol.Lett_18_1337 |
| PubMedID: 31423195 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : NDRG3 protein expression is associated with aggressive biologic phenotype and unfavorable outcome in patients with invasive breast cancer - Kim_2019_Int.J.Clin.Exp.Pathol_12_3886 |
| Author(s) : Kim MC , Park MH , Kang SH , Bae YK |
| Ref : Int J Clin Exp Pathol , 12 :3886 , 2019 |
| Abstract : |
| PubMedSearch : Kim_2019_Int.J.Clin.Exp.Pathol_12_3886 |
| PubMedID: 31933778 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : High NDRG3 expression facilitates HCC metastasis by promoting nuclear translocation of beta-catenin - Shi_2019_BMB.Rep_52_451 |
| Author(s) : Shi J , Zheng H , Yuan L |
| Ref : BMB Rep , 52 :451 , 2019 |
| Abstract : |
| PubMedSearch : Shi_2019_BMB.Rep_52_451 |
| PubMedID: 31072445 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma - Jing_2018_Biosci.Rep_38_ |
| Author(s) : Jing JS , Li H , Wang SC , Ma JM , Yu LQ , Zhou H |
| Ref : Bioscience Reports , 38 : , 2018 |
| Abstract : |
| PubMedSearch : Jing_2018_Biosci.Rep_38_ |
| PubMedID: 30413609 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors - Lee_2018_Exp.Mol.Med_50_61 |
| Author(s) : Lee GY , Shin SH , Shin HW , Chun YS , Park JW |
| Ref : Exp Mol Med , 50 :61 , 2018 |
| Abstract : |
| PubMedSearch : Lee_2018_Exp.Mol.Med_50_61 |
| PubMedID: 29760417 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : High expression of NDRG3 associates with unfavorable overall survival in non-small cell lung cancer - Luo_2018_Cancer.Biomark_21_461 |
| Author(s) : Luo X , Hou N , Chen X , Xu Z , Xu J , Wang L , Yang S , Liu S , Xu L , Chen Y , Xiong L , Wang J , Fan W |
| Ref : Cancer Biomark , 21 :461 , 2018 |
| Abstract : |
| PubMedSearch : Luo_2018_Cancer.Biomark_21_461 |
| PubMedID: 29171988 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : Increased Expression of NDRG3 in Mouse Uterus During Embryo Implantation and in Mouse Endometrial Stromal Cells During In Vitro Decidualization - Yang_2017_Reprod.Sci__1933719117737843 |
| Author(s) : Yang Q , Zhang X , Shi Y , He YP , Sun ZG , Shi HJ , Wang J |
| Ref : Reprod Sci , :1933719117737843 , 2017 |
| Abstract : |
| PubMedSearch : Yang_2017_Reprod.Sci__1933719117737843 |
| PubMedID: 29096585 |
| Gene_locus related to this paper: human-NDRG3 , mouse-ndr3 |
| Title : Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway - Cui_2017_Biochem.Biophys.Res.Commun_491_277 |
| Author(s) : Cui C , Lin H , Shi Y , Pan R |
| Ref : Biochemical & Biophysical Research Communications , 491 :277 , 2017 |
| Abstract : |
| PubMedSearch : Cui_2017_Biochem.Biophys.Res.Commun_491_277 |
| PubMedID: 28743501 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : Clinical significance of NDRG3 in patients with breast cancer - Estiar_2017_Future.Oncol_13_961 |
| Author(s) : Estiar MA , Zare AA , Esmaeili R , Farahmand L , Fazilaty H , Jafari D , Samadi T , Majidzadeh AK |
| Ref : Future Oncol , 13 :961 , 2017 |
| Abstract : |
| PubMedSearch : Estiar_2017_Future.Oncol_13_961 |
| PubMedID: 28326836 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : MicroRNA31-NDRG3 regulation axes are essential for hepatocellular carcinoma survival and drug resistance - Du_2017_Cancer.Biomark_19_221 |
| Author(s) : Du Z , Niu S , Xu X , Xu Q |
| Ref : Cancer Biomark , 19 :221 , 2017 |
| Abstract : |
| PubMedSearch : Du_2017_Cancer.Biomark_19_221 |
| PubMedID: 28269758 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : High expression of NDRG3 associates with positive lymph node metastasis and unfavourable overall survival in laryngeal squamous cell carcinoma - Ma_2016_Pathology_48_691 |
| Author(s) : Ma J , Liu S , Zhang W , Zhang F , Wang S , Wu L , Yan R , Wang C , Zha Z , Sun J |
| Ref : Pathology , 48 :691 , 2016 |
| Abstract : |
| PubMedSearch : Ma_2016_Pathology_48_691 |
| PubMedID: 27780595 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : NDRG3-mediated lactate signaling in hypoxia - Park_2015_BMB.Rep_48_301 |
| Author(s) : Park KC , Lee DC , Yeom YI |
| Ref : BMB Rep , 48 :301 , 2015 |
| Abstract : |
| PubMedSearch : Park_2015_BMB.Rep_48_301 |
| PubMedID: 25936780 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : Prognostic impact of NDRG2 and NDRG3 in prostate cancer patients undergoing radical prostatectomy - Ren_2014_Histol.Histopathol_29_535 |
| Author(s) : Ren GF , Tang L , Yang AQ , Jiang WW , Huang YM |
| Ref : Histol Histopathol , 29 :535 , 2014 |
| Abstract : |
| PubMedSearch : Ren_2014_Histol.Histopathol_29_535 |
| PubMedID: 24222185 |
| Gene_locus related to this paper: human-NDRG2 , human-NDRG3 |
| Title : NDRG3 and NDRG4, two novel tumor-related genes - Yang_2013_Biomed.Pharmacother_67_681 |
| Author(s) : Yang X , An L , Li X |
| Ref : Biomed Pharmacother , 67 :681 , 2013 |
| Abstract : |
| PubMedSearch : Yang_2013_Biomed.Pharmacother_67_681 |
| PubMedID: 23725756 |
| Gene_locus related to this paper: human-NDRG3 , human-NDRG4 |
| Title : miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3 - Fan_2011_Oncol.Rep_26_1281 |
| Author(s) : Fan CG , Wang CM , Tian C , Wang Y , Li L , Sun WS , Li RF , Liu YG |
| Ref : Oncol Rep , 26 :1281 , 2011 |
| Abstract : |
| PubMedSearch : Fan_2011_Oncol.Rep_26_1281 |
| PubMedID: 21725618 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth - Wang_2009_Int.J.Cancer_124_521 |
| Author(s) : Wang W , Li Y , Hong A , Wang J , Lin B , Li R |
| Ref : International Journal of Cancer , 124 :521 , 2009 |
| Abstract : |
| PubMedSearch : Wang_2009_Int.J.Cancer_124_521 |
| PubMedID: 18975380 |
| Gene_locus related to this paper: human-NDRG3 |
| Title : Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family - Qu_2002_Mol.Cell.Biochem_229_35 |
| Author(s) : Qu X , Zhai Y , Wei H , Zhang C , Xing G , Yu Y , He F |
| Ref : Molecular & Cellular Biochemistry , 229 :35 , 2002 |
| Abstract : |
| PubMedSearch : Qu_2002_Mol.Cell.Biochem_229_35 |
| PubMedID: 11936845 |
| Gene_locus related to this paper: human-NDRG1 , human-NDRG2 , human-NDRG3 , human-NDRG4 |
| Title : Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart - Zhou_2001_Genomics_73_86 |
| Author(s) : Zhou RH , Kokame K , Tsukamoto Y , Yutani C , Kato H , Miyata T |
| Ref : Genomics , 73 :86 , 2001 |
| Abstract : |
| PubMedSearch : Zhou_2001_Genomics_73_86 |
| PubMedID: 11352569 |
| Gene_locus related to this paper: human-NDRG2 , human-NDRG3 , human-NDRG4 |