mycle-ML0314

Mycobacterium leprae ML0314c LipU Secreted carboxyl esterase

Comment

ML0314c showed preference for short carbon chain substrates with maximum activity for pNP-acetate. Secreted carboxyl esterase that could modulate the immune response in leprosy patients. Inhibited by Eserine, DEPC and Orlistat

Relationship

Family : Hormone-sensitive_lipase_like

Block : H

Position in NCBI Life Tree : Mycobacterium leprae

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium leprae N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MAISAGAPVE IVESGPSIAA RLASLTSRLT IRPILAVGSY VPQLPWPFGL IDHAARVLLP VTNAARAEVN LSNTSAQLVR AAGVRPADGS GRIVLYLHGG AFLGCGANSH RRLVETLSKL ADSPILVVNY RLLPKHSIGM ALDDCHDGYQ WLRRLGYDPE QIVLAGDSAG GYLALALAQR LQDVGEEPAA LVAISPLLQL AKKGKQAHPN AKTDAMFPPK AFDALGRLVA SSAAKNKVDD KPEELYEPLD HIAPGLPRTL IHVSGSEVLL HDAQLAATKL AAVGVPAEIR VWPGQVHVFQ AAAPMVPEAT LSLRQISQYI REATASKASR DRQSL

References (2)

Title : Characterization of ML0314c of Mycobacterium leprae and deciphering its role in the immune response in leprosy patients - Kaur_2018_Gene_643_26
Author(s) : Kaur G , Sharma A , Narang T , Dogra S , Kaur J
Ref : Gene , 643 :26 , 2018
Abstract :
PubMedSearch : Kaur_2018_Gene_643_26
PubMedID: 29208413
Gene_locus related to this paper: mycle-ML0314

Title : Massive gene decay in the leprosy bacillus - Cole_2001_Nature_409_1007
Author(s) : Cole ST , Eiglmeier K , Parkhill J , James KD , Thomson NR , Wheeler PR , Honore N , Garnier T , Churcher C , Harris D , Mungall K , Basham D , Brown D , Chillingworth T , Connor R , Davies RM , Devlin K , Duthoy S , Feltwell T , Fraser A , Hamlin N , Holroyd S , Hornsby T , Jagels K , Lacroix C , Maclean J , Moule S , Murphy L , Oliver K , Quail MA , Rajandream MA , Rutherford KM , Rutter S , Seeger K , Simon S , Simmonds M , Skelton J , Squares R , Squares S , Stevens K , Taylor K , Whitehead S , Woodward JR , Barrell BG
Ref : Nature , 409 :1007 , 2001
Abstract :
PubMedSearch : Cole_2001_Nature_409_1007
PubMedID: 11234002
Gene_locus related to this paper: mycle-a85a , mycle-a85b , mycle-a85c , mycle-lipG , mycle-LPQC , mycle-metx , mycle-ML0314 , mycle-ML0370 , mycle-ML0376 , mycle-ML1339 , mycle-ML1444 , mycle-ML1632 , mycle-ML1633 , mycle-ML1921 , mycle-ML2269 , mycle-ML2297 , mycle-ML2359 , mycle-ML2603 , mycle-mpt5 , mycle-PKS13 , mycle-PTRB , mycle-q9cc62 , mycle-q9cdb3