Gene_Locus Report

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Gene_locus Report for: macfa-BCHE

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina Butyrylcholinesterase

Comment
Other strains: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina. Uno et al found 26 non-synonymous genetic variants in 121 cynomolgus and 23 rhesus macaques. None of these variants corresponded to the null or defective alleles of human BCHE


Relationship
Family|BCHE
Block| C
Position in NCBI Life Tree|Macaca fascicularis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Cercopithecoidea: N E > Cercopithecidae: N E > Cercopithecinae: N E > Macaca: N E > Macaca fascicularis: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
Sequence
Graphical view for this peptide sequence: macfa-BCHE
Colored MSA for BCHE (raw)
MDSKVTIICIRLLFWFLLLCMLIGKSHTEDDIVIATKNGKVRGMNLTVLG
GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCYQNIDQS
FPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQTGT
SSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQ
LALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAIL
QSGSSNAPWAVTSLYEARNRTLTLAKLTGCSRDNETEIVKCLRNKDPHEI
LLNEAFVVPYGTLLSVNFGPTMDGDFLTEMPDILLELGQFKKTQILVGVN
KDEGTAFLVYGAPGFSKDNDSIITRNEFQEGLKIFFPGVSEFGKESILFH
YTDWVDDQRPENYREALDDVVGDYNIICPALEFTKKFSEWGNNAFFYYFE
HRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTKAEEILSRSIVKRWA
NFAKYGNPNGTHNNSTKWPVFKSTEQKYLTLNTESSRILTKLRAQQCRFW
TSFFPKVLEMTGNIDEAEWEWKAGFHRWSNYMMDWKNQFNDYTSKKESCV
GL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MDSKVTIICIRLLFWFLLLCMLIGKSHTEDDIVIATKNGKVRGMNLTVLG
GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCYQNIDQS
FPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQTGT
SSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQ
LALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAIL
QSGSSNAPWAVTSLYEARNRTLTLAKLTGCSRDNETEIVKCLRNKDPHEI
LLNEAFVVPYGTLLSVNFGPTMDGDFLTEMPDILLELGQFKKTQILVGVN
KDEGTAFLVYGAPGFSKDNDSIITRNEFQEGLKIFFPGVSEFGKESILFH
YTDWVDDQRPENYREALDDVVGDYNIICPALEFTKKFSEWGNNAFFYYFE
HRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTKAEEILSRSIVKRWA
NFAKYGNPNGTHNNSTKWPVFKSTEQKYLTLNTESSRILTKLRAQQCRFW
TSFFPKVLEMTGNIDEAEWEWKAGFHRWSNYMMDWKNQFNDYTSKKESCV
GL


References
    Title: Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques
    Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T
    Ref: J Med Primatol, 47:185, 2018 : PubMed

            

    Title: Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques
    Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y and Wang X <32 more author(s)>
    Ref: Nat Biotechnol, 29:1019, 2011 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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