Gene_locus Report for: rabit-d5fit0 Oryctolagus cuniculus (Rabbit). Lipoprotein lipase
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Lagomorpha: N E > Leporidae: N E > Oryctolagus: N E > Oryctolagus cuniculus: N E ABHD6-Lip :
rabit-g1se63 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
ABHD10 :
rabit-g1skt3 Oryctolagus cuniculus (Rabbit). Abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
rabit-g1t134 Oryctolagus cuniculus (Rabbit). Abhydrolase domain containing 11 .
ABHD12-PHARC :
rabit-g1t9l8 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1sic4 Oryctolagus cuniculus (Rabbit). Uncharacterized protein .
ABHD13-BEM46 :
rabit-g1ta36 Oryctolagus cuniculus (Rabbit). Hydrolase_4 domain-containing protein .
ABHD16 :
rabit-g1tmm5 Oryctolagus cuniculus (Rabbit). Abhydrolase domain containing 16A ,
rabit-g1tqr7 Oryctolagus cuniculus (Rabbit). Abhydrolase domain containing 16B .
ABHD18 :
rabit-g1sp43 Oryctolagus cuniculus (Rabbit). ABHD18 Uncharacterized protein .
abh_upf0017 :
rabit-g1tyf7 Oryctolagus cuniculus (Rabbit). Hydrolase_4 domain-containing protein .
ACHE :
rabit-ACHE Oryctolagus cuniculus mRNA for acetylcholinesterase .
Acidic_Lipase :
rabit-1lipg Oryctolagus cuniculus (rabbit) Precursor of gastric lipase LIPF .
Arb2_FAM172A :
rabit-g1tmw5 Oryctolagus cuniculus (Rabbit). Uncharacterized protein .
Arylacetamide_deacetylase :
rabit-Q7M370 Oryctolagus cuniculus (Rabbit) esterase/n-deacetylase (EC 3.5.1.-), 50k hepatic ,
rabit-g1sn99 Oryctolagus cuniculus (Rabbit). Uncharacterized protein ,
rabit-g1snq9 Oryctolagus cuniculus (Rabbit). Uncharacterized protein ,
rabit-g1sns7 Oryctolagus cuniculus (Rabbit). Uncharacterized protein ,
rabit-g1tuu8 Oryctolagus cuniculus (Rabbit). Uncharacterized protein ,
rabit-g1tzq7 Oryctolagus cuniculus (Rabbit). Uncharacterized protein .
BCHE :
rabit-BCHE Oryctolagus cuniculus partial mRNA for butyrylcholinesterase .
Carb_B_Chordata :
rabit-1cxes ,
rabit-2cxes Oryctolagus cuniculus protein for liver 60 kD carboxylesterase 2 ,
rabit-g1sf73 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1sjq8 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1sn51 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1snb1 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1snb6 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1srm0 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1t6l1 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1t6x7 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1t7p3 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1t7q5 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1t441 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1tdr0 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1tmc5 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1tzv1 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1u6t1 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
Cholesterol_esterase :
rabit-g1tfp2 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
CIB-CCG1-interacting-factor-B :
rabit-g1sye0 Oryctolagus cuniculus (Rabbit). Uncharacterized protein .
CMBL :
rabit-g1sqa1 Oryctolagus cuniculus (Rabbit). Carboxymethylenebutenolidase homolog .
Epoxide_hydrolase :
rabit-hyep Oryctolagus cuniculus (Rabbit) (epoxide hydratase) .
FSH1 :
rabit-g1tnp4 Oryctolagus cuniculus (Rabbit). FSH1 domain-containing protein .
Hepatic_Lipase :
rabit-1hlip Oryctolagus cuniculus (Rabbit) Hepatic triacylglycerol lipase LIPH_RABI LIPC (hl) .
Lipoprotein_Lipase :
rabit-g1tkr5 Oryctolagus cuniculus (Rabbit). Uncharacterized protein .
LYsophospholipase_carboxylesterase :
rabit-lypla1 Oryctolagus cuniculus calcium-independent phospholipase A2 isoform 2 CaIPLA2 ,
rabit-O77820 Oryctolagus cuniculus (Rabbit) calcium-independent phospholipase a2 isoform 1 (fragment) .
Maspardin-ACP33-SPG21_like :
rabit-g1taz4 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
Monoglyceridelipase_lysophospholip :
rabit-g1ssu3 Oryctolagus cuniculus (Rabbit). Uncharacterized protein .
Ndr_family :
rabit-g1tbj4 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1sds3 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
Neuroligin :
rabit-g1sp52 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1td52 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1tyl9 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
NLS3-Tex30 :
rabit-g1shj6 Oryctolagus cuniculus (Rabbit) Uncharacterized protein ,
rabit-g1tw37 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
Pancreatic_lipase :
rabit-1plip Oryctolagus cuniculus mRNA for triacylglycerol lipase ,
rabit-g1sul9 Oryctolagus cuniculus (Rabbit). Pancreatic lipase ,
rabit-g1sun0 Oryctolagus cuniculus (Rabbit). Pancreatic lipase ,
rabit-g1sup0 Oryctolagus cuniculus (Rabbit). Pancreatic lipase .
PC-sterol_acyltransferase :
rabit-lcat Rabbit mRNA for lecithin-cholesterol acyltransferase .
Phospholipase :
rabit-LIPH Oryctolagus cuniculus (Rabbit) Lipase H (LIPH) (lacrimal lipase); Membrane-associated phosphatidic acid-selective phospholipase A1-alpha ,
rabit-g1sxd0 Oryctolagus cuniculus (Rabbit). Phospholipase A1 member A ,
rabit-a0a5f9cru6 Oryctolagus cuniculus (Rabbit). Lipase I .
SERHL :
rabit-g1sgz5 Oryctolagus cuniculus (Rabbit). Serine hydrolase like 2 .
Thyroglobulin :
rabit-g1siu8 Oryctolagus cuniculus (Rabbit) Uncharacterized protein .
Valacyclovir-hydrolase :
rabit-g1sxz9 Oryctolagus cuniculus (Rabbit) Uncharacterized protein Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: rabit-d5fit0 Colored MSA for Lipoprotein_Lipase (raw)
MESKTLLLVVLGAWLQSLTASRGGVAAADRNDFLDIETKFALRTPEDTAD
DTCHLVPGVVESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYK
REPDSNVIVVDWLLRAQQHYPVSAGYTKLVGKDVARFINWMEEEFNYPLD
NVHLLGYSLGAHAAGIAGSLTNRKVNRITGLDPAGPNFEYAEAPSRLSPD
DADFVDVLHTFTRGSPGRSIGIQQPVGHVDIYPNGGTFQPGCNIGEAIRV
IAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCTSKEAFEKGL
CLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRAQMPYKVFHYQVKIHFSG
TESQTQTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGE
LLMMKLKWNSDSYFSWADWWGSPSFTIAKIRVKAGETQKKVIFCSREKVS
HLQKGKAALVFVKCHDKSLNNKSG
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M E S K T L L L V V L G A W L Q S L T A S R G G V A A A D R N D F L D I E T K F A L R T P E D T A D D T C H L V P G V V E S V A N C H F N H S S K T F V V I H G W T V T G M Y E S W V P K L V A A L Y K R E P D S N V I V V D W L L R A Q Q H Y P V S A G Y T K L V G K D V A R F I N W M E E E F N Y P L D N V H L L G Y S L G A H A A G I A G S L T N R K V N R I T G L D P A G P N F E Y A E A P S R L S P D D A D F V D V L H T F T R G S P G R S I G I Q Q P V G H V D I Y P N G G T F Q P G C N I G E A I R V I A E R G L G D V D Q L V K C S H E R S I H L F I D S L L N E E N P S K A Y R C T S K E A F E K G L C L S C R K N R C N N L G Y E I N K V R A K R S S K M Y L K T R A Q M P Y K V F H Y Q V K I H F S G T E S Q T Q T N Q A F E I S L Y G T V A E S E N I P F T L P E V S T N K T Y S F L I Y T E V D I G E L L M M K L K W N S D S Y F S W A D W W G S P S F T I A K I R V K A G E T Q K K V I F C S R E K V S H L Q K G K A A L V F V K C H D K S L N N K S G
Reference
Title: A high-resolution map of human evolutionary constraint using 29 mammalsLindblad-Toh K , Garber M , Zuk O , Lin MF , Parker BJ , Washietl S , Kheradpour P , Ernst J , Jordan G and Kellis M <76 more author(s)> Lindblad-Toh K , Garber M , Zuk O , Lin MF , Parker BJ , Washietl S , Kheradpour P , Ernst J , Jordan G , Mauceli E , Ward LD , Lowe CB , Holloway AK , Clamp M , Gnerre S , Alfoldi J , Beal K , Chang J , Clawson H , Cuff J , Di Palma F , Fitzgerald S , Flicek P , Guttman M , Hubisz MJ , Jaffe DB , Jungreis I , Kent WJ , Kostka D , Lara M , Martins AL , Massingham T , Moltke I , Raney BJ , Rasmussen MD , Robinson J , Stark A , Vilella AJ , Wen J , Xie X , Zody MC , Baldwin J , Bloom T , Chin CW , Heiman D , Nicol R , Nusbaum C , Young S , Wilkinson J , Worley KC , Kovar CL , Muzny DM , Gibbs RA , Cree A , Dihn HH , Fowler G , Jhangiani S , Joshi V , Lee S , Lewis LR , Nazareth LV , Okwuonu G , Santibanez J , Warren WC , Mardis ER , Weinstock GM , Wilson RK , Delehaunty K , Dooling D , Fronik C , Fulton L , Fulton B , Graves T , Minx P , Sodergren E , Birney E , Margulies EH , Herrero J , Green ED , Haussler D , Siepel A , Goldman N , Pollard KS , Pedersen JS , Lander ES , Kellis M (- 76) Ref: Nature, 478 :476, 2011 : PubMed Abstract ESTHER: Lindblad-Toh_2011_Nature_478_476 PubMedSearch: Lindblad-Toh 2011 Nature 478 476 PubMedID: 21993624 Gene_locus related to this paper: cavpo-1plip ,
cavpo-2plrp ,
cavpo-h0v1b7 ,
cavpo-h0v5v8 ,
cavpo-h0vj36 ,
cavpo-lipli ,
rabit-1hlip ,
rabit-1plip ,
rabit-g1t6x7 ,
rabit-LIPH ,
myolu-l7n1c2 ,
myolu-g1pqd9 ,
cavpo-h0uyz6 ,
cavpo-h0vi56 ,
rabit-g1tbj4 ,
myolu-g1p5c0 ,
rabit-g1sds3 ,
rabit-g1sye0 ,
cavpo-h0v0r2 ,
cavpo-h0v7s5 ,
rabit-g1sp43 ,
myolu-g1p4p3 ,
cavpo-h0vw09 ,
rabit-g1ssu3 ,
myolu-g1pds0 ,
rabit-g1sic4 ,
cavpo-h0v2c4 ,
myolu-g1pg61 ,
myolu-g1pnb1 ,
myolu-g1pu06 ,
myolu-g1qa15 ,
myolu-g1qfu0 ,
rabit-g1sn99 ,
rabit-g1snq9 ,
rabit-g1sns7 ,
rabit-g1tuu8 ,
rabit-g1tzq7 ,
cavpo-h0v2i2 ,
cavpo-h0v2j0 ,
cavpo-h0vsf5 ,
cavpo-a0a286x8d3 ,
cavpo-a0a286xbr3 ,
cavpo-a0a286y0i8 ,
cavpo-a0a286y4p3 ,
myolu-g1q2n9 ,
cavpo-h0v1p4 ,
myolu-g1pan8 ,
myolu-g1paq0 ,
myolu-g1par4 ,
myolu-g1prn3 ,
myolu-g1q3i0 ,
myolu-g1q463 ,
myolu-g1pat6 ,
myolu-g1q859 ,
rabit-g1sul9 ,
rabit-g1sun0 ,
rabit-g1sup0 ,
myolu-l7n125 ,
myolu-g1pan2 ,
rabit-g1sxd0 ,
cavpo-h0v8j4 ,
rabit-d5fit0 ,
rabit-g1tkr5 ,
myolu-g1nty6 ,
myolu-g1p1p3 ,
cavpo-h0vdd5 ,
myolu-g1pdp2 ,
rabit-g1tmm5 ,
cavpo-h0vhq3 ,
myolu-g1nth4 ,
cavpo-h0vqx6 ,
rabit-g1tqr7 ,
myolu-g1p1e9 ,
cavpo-h0v8y6 ,
rabit-g1skt3 ,
myolu-g1nzg3 ,
cavpo-h0v5z0 ,
rabit-g1sgz5 ,
myolu-g1pkg5 ,
rabit-g1tmw5 ,
rabit-g1t134 ,
cavpo-a0a286x9v5 ,
myolu-g1qc57 ,
myolu-g1q061 ,
rabit-g1tnp4 ,
rabit-g1tyf7 ,
cavpo-h0w2w1 ,
rabit-g1ta36 ,
cavpo-h0w342 ,
myolu-g1q4e3 ,
rabit-g1sqa1 ,
cavpo-h0uxk7 ,
myolu-g1p353 ,
cavpo-h0vpm0 ,
rabit-a0a5f9cru6 ,
cavpo-a0a286xtc0 Abstract
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering approximately 4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for approximately 60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease.
Other Papers
Oryctolagus cuniculus protein for liver 60 kD carboxylesterase 1