9-Amino-6-chloro-2-methoxyacridine
General
Type : Acridine, Derivative of Tacrine, Organochlorine
Chemical_Nomenclature : 6-chloro-2-methoxyacridin-9-amine
Canonical SMILES : COC1=CC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)N
InChI : InChI=1S\/C14H11ClN2O\/c1-18-9-3-5-12-11(7-9)14(16)10-4-2-8(15)6-13(10)17-12\/h2-7H,1H3,(H2,16,17)
InChIKey : IHHSSHCBRVYGJX-UHFFFAOYSA-N
Other name(s) : ACMA || G 185 || 6-Chloro-2-methoxy-9-acridinamine || NSC 15300 || 2-methoxy-6-chloro-9-aminoacridine || CHEMBL76954 || SCHEMBL106725 || SCHEMBL9641759 || SCHEMBL29365544 || SCHEMBL29445571
MW : 258.70
Formula : C14H11ClN2O
CAS_number : 3548-09-2
PubChem : 19080
UniChem : IHHSSHCBRVYGJX-UHFFFAOYSA-N
Target
Families : 9-Amino-6-chloro-2-methoxyacridine ligand of proteins in family
Carboxylesterase
Carb_B_Chordata
References (3)
| Title : Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors - Tsurkan_2013_Chem.Biol.Interact_203_226 |
| Author(s) : Tsurkan LG , Hatfield MJ , Edwards CC , Hyatt JL , Potter PM |
| Ref : Chemico-Biological Interactions , 203 :226 , 2013 |
| Abstract : |
| PubMedSearch : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedID: 23123248 |
| Title : Mammalian carboxylesterases: from drug targets to protein therapeutics - Redinbo_2005_Drug.Discov.Today_10_313 |
| Author(s) : Redinbo MR , Potter PM |
| Ref : Drug Discov Today , 10 :313 , 2005 |
| Abstract : |
| PubMedSearch : Redinbo_2005_Drug.Discov.Today_10_313 |
| PubMedID: 15749280 |
| Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341 |
| Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR |
| Ref : Chemical Biology , 10 :341 , 2003 |
| Abstract : |
| PubMedSearch : Bencharit_2003_Chem.Biol_10_341 |
| PubMedID: 12725862 |
| Gene_locus related to this paper: human-CES1 |