Amiridine-Aminomethylidene-5b
AChE IC50 3.09 microM BChE IC50 0.063 microM
General
Type : Derivative of Amiridine, Trifluoro, Oxobutanoate
Chemical_Nomenclature : 4,4,4-trifluoro-2-[({6-[(2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino]hexyl}amino)methylene]-3-oxobutanoate
Canonical SMILES : C13=C(N=C2C(=C1N(CCCCCCN(C=C(C(OCC)=O)C(C(F)(F)F)=O)[H])[H])CCCC2)CCC3
InChI : InChI=1S\/C25H34F3N3O3\/c1-2-34-24(33)19(23(32)25(26,27)28)16-29-14-7-3-4-8-15-30-22-17-10-5-6-12-20(17)31-21-13-9-11-18(21)22\/h16,29H,2-15H2,1H3,(H,30,31)
InChIKey : YKISHPOCQBHUEA-UHFFFAOYSA-N
Other name(s) :
Target
References (1)
| Title : Synthesis of Tacrine\/Amiridine Conjugates with Aminomethylidene Derivatives of Trifluoroacetoacetic Ester and their Biological Potential for the Therapy of Alzheimer's Disease - Grishchenko_2025_ChemMedChem__e202500723 |
| Author(s) : Grishchenko MV , Makhaeva GF , Burgart YV , Kovaleva NV , Boltneva NP , Skornyakova TS , Rudakova EV , Astakhova TY , Timokhina EN , Pronkin PG , Shchegolkov EV , Saloutin V , Charushin VN |
| Ref : ChemMedChem , :e202500723 , 2025 |
| Abstract : |
| PubMedSearch : Grishchenko_2025_ChemMedChem__e202500723 |
| PubMedID: 41047157 |