Atracurium
Neuromuscular Nondepolarizing Agent, Nicotinic Antagonist, Neuromuscular blocking agent, (close to doxacurium) Cisatracurium is the 1R-cis 1'R-cis isomer of atracurium. Atracurium and Cisatracurium undergo spontaneous non-organ-dependent Hofmann degradation at physiological pH and temperature. Ligand of small conductance Ca2+-activated K+ (SKca) channels
General
Type : Not A\/B H target, Neuromuscular Nondepolarizing Agents, Drug, Isoquinoline, Propionate
Chemical_Nomenclature : 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
Canonical SMILES : C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C || C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-]
InChI : InChI=1S\/C53H72N2O12\/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6\/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3\/q+2 || InChI=1S\/C53H72N2O12.2C6H6O3S\/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6\;2*7-10(8,9)6-4-2-1-3-5-6\/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3\;2*1-5H,(H,7,8,9)\/q+2\;\;\/p-2 || InChI=1S\/C53H72N2O12.2C6H6O3S\/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6\;2*7-10(8,9)6-4-2-1-3-5-6\/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3\;2*1-5H,(H,7,8,9)\/q+2\;\;\/p-2\/t42-,43-,54-,55-\;\;\/m1..\/s1
InChIKey : YXSLJKQTIDHPOT-UHFFFAOYSA-N || XXZSQOVSEBAPGS-UHFFFAOYSA-L
Other name(s) : Isoquinolinium, 1,2,3,4-tetrahydro-2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-2-methyl-Isoquinolinium || Atracurium besylate || Tracrium || BW 33A || Prestwick1_000005 || SPBio_001930 || BRN 1523633 || C07548 || 64228-79-1 || 64228-81-5 || Isoquinolinium, 1,2,3,4-tetrahydro-2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-2-methyl- || Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl- || Nimbex || NCGC00017127-01 || 51W89
MW : 929.145
Formula : C53H72N2O12
CAS_number : 64228-79-1, 64228-81-5
UniChem : YXSLJKQTIDHPOT-UHFFFAOYSA-N, XXZSQOVSEBAPGS-UHFFFAOYSA-L
Wikipedia : Atracurium_besilate
Target
Families : Atracurium ligand of proteins in family
BCHE
References (14)
| Title : Antagonism of atracurium-induced block in obese patients - Kirkegaard-Nielsen_1998_Can.J.Anaesth_45_39 |
| Author(s) : Kirkegaard-Nielsen H , Lindholm P , Petersen HS , Severinsen IK |
| Ref : Canadian Journal of Anaesthesia , 45 :39 , 1998 |
| Abstract : |
| PubMedSearch : Kirkegaard-Nielsen_1998_Can.J.Anaesth_45_39 |
| PubMedID: 9466025 |
| Title : [Esters and stereoisomers] - Nigrovic_1997_Anaesthesist_46_282 |
| Author(s) : Nigrovic V , Diefenbach C , Mellinghoff H |
| Ref : Anaesthesist , 46 :282 , 1997 |
| Abstract : |
| PubMedSearch : Nigrovic_1997_Anaesthesist_46_282 |
| PubMedID: 9229981 |
| Title : [Profile of the effect of succinylcholine after pre-curarization with atracurium, vecuronium or pancuronium] - Ebeling_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_304 |
| Author(s) : Ebeling BJ , Keienburg T , Hausmann D , Apffelstaedt C |
| Ref : Anasthesiol Intensivmed Notfallmed Schmerzther , 31 :304 , 1996 |
| Abstract : |
| PubMedSearch : Ebeling_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_304 |
| PubMedID: 8767244 |
| Title : Administration of 51W89 by infusion--a comparison with atracurium-- preliminary communication - |
| Author(s) : Mellinghoff H , Diffenbach C , Buzello W |
| Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :95 , 1995 |
| PubMedID: 8533556 |
| Title : Spontaneous recovery or evoked reversal of neuromuscular block - Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
| Author(s) : Mirakhur RK |
| Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :62 , 1995 |
| Abstract : |
| PubMedSearch : Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
| PubMedID: 8533549 |
| Title : Newer neuromuscular blocking agents - Bevan_1994_Pharmacol.Toxicol_74_3 |
| Author(s) : Bevan DR |
| Ref : Pharmacol Toxicol , 74 :3 , 1994 |
| Abstract : |
| PubMedSearch : Bevan_1994_Pharmacol.Toxicol_74_3 |
| PubMedID: 8159634 |
| Title : Suxamethonium and atracurium: sequential and simultaneous administration - Harper_1993_Eur.J.Anaesthesiol_10_13 |
| Author(s) : Harper NJ , Chadwick IS , Linsley A |
| Ref : European Journal of Anaesthesiology , 10 :13 , 1993 |
| Abstract : |
| PubMedSearch : Harper_1993_Eur.J.Anaesthesiol_10_13 |
| PubMedID: 8432269 |
| Title : Electroconvulsive therapy and the chronic use of pseudocholinesterase- inhibitor (echothiophate iodide) eye drops for glaucoma. A case report - Messer_1992_Gen.Hosp.Psychiatry_14_56 |
| Author(s) : Messer GJ , Stoudemire A , Knos G , Johnson GC |
| Ref : General Hospital Psychiatry , 14 :56 , 1992 |
| Abstract : |
| PubMedSearch : Messer_1992_Gen.Hosp.Psychiatry_14_56 |
| PubMedID: 1730402 |
| Title : Atracurium administration, as an infusion, to induce neuromuscular blockade in clinically normal and temporarily immune-suppressed cats - Ilkiw_1990_J.Am.Vet.Med.Assoc_197_1153 |
| Author(s) : Ilkiw JE , Forsyth SF , Hill T , Gregory CR |
| Ref : J Am Vet Med Assoc , 197 :1153 , 1990 |
| Abstract : |
| PubMedSearch : Ilkiw_1990_J.Am.Vet.Med.Assoc_197_1153 |
| PubMedID: 2254141 |
| Title : The effect of the organophosphate trichlorfon on the neuromuscular blocking activity of atracurium in halothane-anesthetized horses - Hildebrand_1989_J.Vet.Pharmacol.Ther_12_277 |
| Author(s) : Hildebrand SV , Hill Td , Holland M |
| Ref : J Vet Pharmacol Ther , 12 :277 , 1989 |
| Abstract : |
| PubMedSearch : Hildebrand_1989_J.Vet.Pharmacol.Ther_12_277 |
| PubMedID: 2810476 |
| Title : Clinical pharmacology of mivacurium chloride (BW B1090U) infusion: comparison with vecuronium and atracurium - Ali_1988_Br.J.Anaesth_61_541 |
| Author(s) : Ali HH , Savarese JJ , Embree PB , Basta SJ , Stout RG , Bottros LH , Weakly JN |
| Ref : British Journal of Anaesthesia , 61 :541 , 1988 |
| Abstract : |
| PubMedSearch : Ali_1988_Br.J.Anaesth_61_541 |
| PubMedID: 2905143 |
| Title : Protein binding of atracurium and other short-acting neuromuscular blocking agents and their interaction with human cholinesterases - Foldes_1983_Br.J.Anaesth_55_31S |
| Author(s) : Foldes FF , Deery A |
| Ref : British Journal of Anaesthesia , 55 :31S , 1983 |
| Abstract : |
| PubMedSearch : Foldes_1983_Br.J.Anaesth_55_31S |
| PubMedID: 6134540 |
| Title : Clinical pharmacology of atracurium besylate (BW 33A): a new non- depolarizing muscle relaxant - Basta_1982_Anesth.Analg_61_723 |
| Author(s) : Basta SJ , Ali HH , Savarese JJ , Sunder N , Gionfriddo M , Cloutier G , Lineberry C , Cato AE |
| Ref : Anesthesia & Analgesia , 61 :723 , 1982 |
| Abstract : |
| PubMedSearch : Basta_1982_Anesth.Analg_61_723 |
| PubMedID: 6213181 |
| Title : The pharmacology of atracurium: a new competitive neuromuscular blocking agent - Hughes_1981_Br.J.Anaesth_53_31 |
| Author(s) : Hughes R , Chapple DJ |
| Ref : British Journal of Anaesthesia , 53 :31 , 1981 |
| Abstract : |
| PubMedSearch : Hughes_1981_Br.J.Anaesth_53_31 |
| PubMedID: 6161627 |