Bis-alkylene-Amiridine-3c
IC50 hACHE 1.46 +/- 0.03 microM eqBChE 0.067 +/- 0.001 microM
General
Type : Derivative of Amiridine, Quinoline, Alkyl linked bis-ligand
Chemical_Nomenclature : 2,2-[1,3-Butanediylbis(imino)]bis[N-(2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-yl)-acetamide
Canonical SMILES : N(C1=C3C(=NC2=C1CCC2)CCCC3)C(CNCCCCNCC(NC4=C6C(=NC5=C4CCC5)CCCC6)=O)=O
InChI : InChI=1S\/C32H44N6O2\/c39-29(37-31-21-9-1-3-13-25(21)35-27-15-7-11-23(27)31)19-33-17-5-6-18-34-20-30(40)38-32-22-10-2-4-14-26(22)36-28-16-8-12-24(28)32\/h33-34H,1-20H2,(H,35,37,39)(H,36,38,40)
InChIKey : GSBGMPKFLCWHGP-UHFFFAOYSA-N
Other name(s) :
Target
References (1)
| Title : Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile - Makhaeva_2022_Molecules_27_ |
| Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Astakhova TY , Serkov IV , Proshin AN , Radchenko EV , Palyulin VA , Korabecny J , Soukup O , Bachurin SO , Richardson RJ |
| Ref : Molecules , 27 : , 2022 |
| Abstract : |
| PubMedSearch : Makhaeva_2022_Molecules_27_ |
| PubMedID: 35164325 |