Chlorpromazine

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. It is one of the most sedating of the typical antipsychotics and also causes antimuscarinic effects. Tricyclic amine-containing compound

General

Type : Not A\/B H target, Phenothiazine, Multitarget, Drug, Sulfur Compound

Chemical_Nomenclature : 8-chlorpromazine, 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine

Canonical SMILES : CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl

InChI : InChI=1S\/C17H19ClN2S\/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20\/h3-4,6-9,12H,5,10-11H2,1-2H3

InChIKey : ZPEIMTDSQAKGNT-UHFFFAOYSA-N

Other name(s) : Propaphenin  ||  Largactil  ||  Thorazin  ||  Contomin  ||  Megaphen  ||  Cromedazine  ||  Plegomazin  ||  Chloropromazine  ||  Chlorderazin  ||  Thorazine  ||  Ormazine  ||  Thor-prom


MW : 355.3-318.86

Formula : C17H19ClN2S

CAS_number : 69-09-0,    50-53-3

PubChem : 2726

UniChem : ZPEIMTDSQAKGNT-UHFFFAOYSA-N

IUPHAR : 83

Wikipedia : Chlorpromazine

Target

Families : Chlorpromazine ligand of proteins in family
ACHE BCHE

References (6)

Title : Inactivation of cholinesterase induced by chlorpromazine cation radicals - Muraoka_2003_Pharmacol.Toxicol_92_100
Author(s) : Muraoka S , Miura T
Ref : Pharmacol Toxicol , 92 :100 , 2003
Abstract :
PubMedSearch : Muraoka_2003_Pharmacol.Toxicol_92_100
PubMedID: 12747580

Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T
Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002
Abstract :
PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedID: 12443046

Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074
Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P
Ref : Biochemistry , 32 :12074 , 1993
Abstract :
PubMedSearch : Radic_1993_Biochemistry_32_12074
PubMedID: 8218285

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
Abstract :
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE

Title : Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide - Whittaker_1981_Hum.Hered_31_242
Author(s) : Whittaker M , Britten JJ
Ref : Hum Hered , 31 :242 , 1981
Abstract :
PubMedSearch : Whittaker_1981_Hum.Hered_31_242
PubMedID: 7287015

Title : The activity of various esterase inhibitors towards atypical human serum cholinesterase -
Author(s) : Kalow W , Davies R0
Ref : Biochemical Pharmacology , 1 :183 , 1958
PubMedID: