Colchicine-donepezil-SBN-284-3x
Colchicine inhibits NF-B signaling and NLRP3 (NOD-like receptor pyrin domain-containing protein 3) inflammasome activation. Colchicine is one of the oldest anti-inflammatory natural products still used clinically. EleelAChE IC50 0.37 microM hAChE 0.31 microM, eqBChE IC50 0.29microM, NLRP3 inflamm EC50 1microM
General
Type : Multitarget, Derivative of Donepezil, Piperidin
Chemical_Nomenclature : N-[(7S)-10-[aminobenzylpiperidin-4-yl)ethyl]-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Canonical SMILES : C3CC1=CC(=C(C(=C1C2=CC=C(C(C=C2[C@H]3NC(=O)C)=O)NCCC4CCN(CC4)CC5=CC=CC=C5)OC)OC)OC
InChI : InChI=1S\/C35H43N3O5\/c1-23(39)37-29-12-10-26-20-32(41-2)34(42-3)35(43-4)33(26)27-11-13-30(31(40)21-28(27)29)36-17-14-24-15-18-38(19-16-24)22-25-8-6-5-7-9-25\/h5-9,11,13,20-21,24,29H,10,12,14-19,22H2,1-4H3,(H,36,40)(H,37,39)\/t29-\/m0\/s1
InChIKey : RQRZPMGJYIKLDP-LJAQVGFWSA-N
Other name(s) : SBN-284 || Compound 3x
Target
Families : Colchicine-donepezil-SBN-284-3x ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Synthesis and Biological Evaluation of ColchicineAryl\/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual Inhibitor of Cholinesterases and NLRP3 Inflammasome - Reddy_2024_ACS.Chem.Neurosci__ |
| Author(s) : Reddy CN , Nuthakki VK , Sharma A , Malik S , Tabassum M , Kumar R , Choudhary S , Iqbal F , Tufail Z , Mondhe DM , Kumar A , Bharate SB |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : |
| PubMedSearch : Reddy_2024_ACS.Chem.Neurosci__ |
| PubMedID: 39056181 |