NLRP3 inflammasome activation
General
NLRP3 inflammasome activation is a critical innate immune response where the NLRP3 protein senses various cellular stresses (like microbial infections, particulate matter, or damaged cell signals) to form a multiprotein complex that activates caspase-1, leading to the maturation and release of potent pro-inflammatory cytokines IL-1 and IL-18, and triggering pyroptosis (inflammatory cell death) via Gasdermin D. Used as building blocks of Multi-target drug ligand MTDL
| Inhibitor | Main targeted enzyme families | Type | Structure |
|---|---|---|---|
| Nlrp3-IN-33-Cpd12o | ACHE BCHE | Acrylate Feruloyl Quinoline Hydroxycinnamic-ester Multitarget Cinnamate NLRP3 inflammasome activation |
|
| Colchicine-donepezil-SBN-284-3x | ACHE BCHE | Multitarget Benzylpiperidine Derivative of Donepezil Piperidine NLRP3 inflammasome activation |
|