FEPAD

IC50 values for hMAGL-expressing cell lines 77.6 +/- 9.2 nM and recombinant hMAGL 23.8 +/- 4.9 nM. A superior to 100-fold selectivity over other major serine hydrolases, including FAAH, ABHD6, ABHD12, and KIAA1363, and CB1/CB2 receptors. F-18 labeled radioligand [18F]FEPAD is a PET probe for non-invasive assessment of MAGL brown adipose tissue

General

Type : Piperazine, Azetidin, Trifluoro, Thiazolidine, Sulfur Compound, PET probe

Chemical_Nomenclature : (4-(1-(4'-chloro-2-(2-fluoroethoxy)-3'-(trifluoromethyl)-[1,1'-biphenyl]-4- carbonyl)azetidin-3-yl)piperazin -1-yl)(thiazol-2-yl)methanone

Canonical SMILES : C1CN(CCN1C2CN(C2)C(=O)C3=CC=C(C(=C3)OCCF)C4=CC=C(C(=C4)C(F)(F)F)Cl)C(C5=NC=CS5)=O

InChI : InChI=1S\/C27H25ClF4N4O3S\/c28-22-4-2-17(13-21(22)27(30,31)32)20-3-1-18(14-23(20)39-11-5-29)25(37)36-15-19(16-36)34-7-9-35(10-8-34)26(38)24-33-6-12-40-24\/h1-4,6,12-14,19H,5,7-11,15-16H2

InChIKey : CUWKHRITMRZSAU-UHFFFAOYSA-N

Other name(s) :


MW : 597.O2

Formula : C27H25ClF4N4O3S

CAS_number :

PubChem :

UniChem : CUWKHRITMRZSAU-UHFFFAOYSA-N

Target

Families : FEPAD ligand of proteins in family
Monoglyceridelipase_lysophospholip

Protein :
human-MGLL

References (1)

Title : A novel monoacylglycerol lipase-targeted (18)F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network - Cheng_2022_Acta.Pharmacol.Sin__
Author(s) : Cheng R , Fujinaga M , Yang J , Rong J , Haider A , Ogasawara D , Van RS , Shao T , Chen Z , Zhang X , Calderon Leon ER , Zhang Y , Mori W , Kumata K , Yamasaki T , Xie L , Sun S , Wang L , Ran C , Shao Y , Cravatt B , Josephson L , Zhang MR , Liang SH
Ref : Acta Pharmacol Sin , : , 2022
Abstract :
PubMedSearch : Cheng_2022_Acta.Pharmacol.Sin__
PubMedID: 35513432
Gene_locus related to this paper: human-MGLL