Indol-ethyl-fluorophenethyl-triazin-triamine-Cpd50
BuChE IC50 = 2.53 microM; 5-HT7 Ki = 1 nM
General
Type : Multitarget, 5-HT-receptor-ligand, Triazine, Indole
Chemical_Nomenclature : N2-(2-(1H-indol-3-yl)ethyl)-N4-(4-fluorophenethyl)-1,3,5-triazine-2,4,6-triamine
Canonical SMILES : N1=C(C=C(N=C1N)NCCC2=CC=C(C=C2)F)NCCC3=C[N]C4=C3C=CC=C4
InChI : InChI=1S\/C22H23FN6\/c23-17-7-5-15(6-8-17)9-11-25-20-13-21(29-22(24)28-20)26-12-10-16-14-27-19-4-2-1-3-18(16)19\/h1-8,13-14,27H,9-12H2,(H4,24,25,26,28,29)
InChIKey : LYRLWBOXTCHTCI-UHFFFAOYSA-N
Other name(s) : Compound 50
Target
Families : Indol-ethyl-fluorophenethyl-triazin-triamine-Cpd50 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of new dual butyrylcholinesterase (BuChE) inhibitors and 5-HT(7) receptor antagonists as compounds used to treat Alzheimer's disease symptoms - Kulaga_2025_Biomed.Pharmacother_186_117995 |
| Author(s) : Kulaga D , Drabczyk AK , Zareba P , Jaskowska J , Satala G , Wieckowska A , de Candia M , Purgatorio R , Boguszewska-Czubara A , Sudol-Talaj S , Latacz G , Plazuk D |
| Ref : Biomed Pharmacother , 186 :117995 , 2025 |
| Abstract : |
| PubMedSearch : Kulaga_2025_Biomed.Pharmacother_186_117995 |
| PubMedID: 40106969 |