| Title : Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases - Carrieri_2024_Bioorg.Med.Chem_110_117829 |
| Author(s) : Carrieri A , Barbarossa A , de Candia M , Samarelli F , Damiano Altomare C , Czarnota-Lydka K , Sudol-Talaj S , Latacz G , Handzlik J , Brunetti L , Piemontese L , Limongelli F , Lentini G , Carocci A |
| Ref : Bioorganic & Medicinal Chemistry , 110 :117829 , 2024 |
| Abstract : |
| PubMedSearch : Carrieri_2024_Bioorg.Med.Chem_110_117829 |
| PubMedID: 39002183 |
| Title : Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of Alzheimer's disease - Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| Author(s) : Panek D , Pasieka A , Jonczyk JJ , Gawlinska M , Zareba P , Siwek A , Wolak M , Mordyl B , Gluch-Lutwin M , Latacz G , Brazzolotto X , Chantegreil F , Nachon F , Zdarova Karasova J , Pejchal J , Mzik M , Sestak V , Prchal L , Odvarkova J , Soukup O , Korabecny J , Sorf A , Hamsikova M , Zemanova L , Muckova L , Vanova N , Dryja P , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Angew Chem Int Ed Engl , :e202420510 , 2024 |
| Abstract : |
| PubMedSearch : Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| PubMedID: 39523866 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135 |
| Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023 |
| Abstract : |
| PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135 |
| PubMedID: 36696766 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, beta-secretase, and amyloid beta aggregation as potential treatment of Alzheimer's disease - Zareba_2023_Eur.J.Med.Chem_261_115832 |
| Author(s) : Zareba P , Latka K , Mazur G , Gryzlo B , Pasieka A , Godyn J , Panek D , Skrzypczak-Wiercioch A , Hofner GC , Latacz G , Maj M , Espargaro A , Sabate R , Jozwiak K , Wanner KT , Salat K , Malawska B , Kulig K , Bajda M |
| Ref : Eur Journal of Medicinal Chemistry , 261 :115832 , 2023 |
| Abstract : |
| PubMedSearch : Zareba_2023_Eur.J.Med.Chem_261_115832 |
| PubMedID: 37837674 |
| Title : Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and beta-amyloid inhibitors for the treatment of Alzheimer's disease - Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| Author(s) : Pasieka A , Panek D , Zareba P , Slugocka E , Gucwa N , Espargaro A , Latacz G , Khan N , Bucki A , Sabate R , Wieckowska A , Malawska B |
| Ref : Bioorganic & Medicinal Chemistry , 88-89 :117333 , 2023 |
| Abstract : |
| PubMedSearch : Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| PubMedID: 37236021 |
| Title : Guanidines: Synthesis of Novel Histamine H(3)R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect - Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| Author(s) : Staszewski M , Iwan M , Werner T , Bajda M , Godyn J , Latacz G , Korga-Plewko A , Kubik J , Szalaj N , Stark H , Malawska B , Wieckowska A , Walczynski K |
| Ref : Pharmaceuticals (Basel) , 16 : , 2023 |
| Abstract : |
| PubMedSearch : Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| PubMedID: 37242458 |
| Title : Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT(6)R ligands with noticeable action on AChE\/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease - Czarnota-Lydka_2023_Eur.J.Med.Chem_259_115695 |
| Author(s) : Czarnota-Lydka K , Sudol-Talaj S , Kucwaj-Brysz K , Kurczab R , Satala G , de Candia M , Samarelli F , Altomare CD , Carocci A , Barbarossa A , eslawska E , Gluch-Lutwin M , Mordyl B , Kubacka M , Wilczynska-Zawal N , Jastrzebska-Wiesek M , Partyka A , Khan N , Wiecek M , Nitek W , Honkisz-Orzechowska E , Latacz G , Wesolowska A , Carrieri A , Handzlik J |
| Ref : Eur Journal of Medicinal Chemistry , 259 :115695 , 2023 |
| Abstract : |
| PubMedSearch : Czarnota-Lydka_2023_Eur.J.Med.Chem_259_115695 |
| PubMedID: 37567058 |
| Title : Serotonin 5-HT(6) Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease - Wieckowski_2022_Int.J.Mol.Sci_23_9443 |
| Author(s) : Wieckowski K , Szalaj N , Gryzlo B , Wichur T , Goral I , Slugocka E , Sniecikowska J , Latacz G , Siwek A , Godyn J , Bucki A , Kolaczkowski M , Wieckowska A |
| Ref : Int J Mol Sci , 23 : , 2022 |
| Abstract : |
| PubMedSearch : Wieckowski_2022_Int.J.Mol.Sci_23_9443 |
| PubMedID: 36012707 |
| Title : Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease - Godyn_2022_Molecules_28_ |
| Author(s) : Godyn J , Zareba P , Stary D , Kaleta M , Kuder KJ , Latacz G , Mogilski S , Reiner-Link D , Frank A , Doroz-Plonka A , Olejarz-Maciej A , Sudol-Talaj S , Nolte T , Handzlik J , Stark H , Wieckowska A , Malawska B , Kiec-Kononowicz K , Lazewska D , Bajda M |
| Ref : Molecules , 28 : , 2022 |
| Abstract : |
| PubMedSearch : Godyn_2022_Molecules_28_ |
| PubMedID: 36615435 |
| Title : Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties - Wichur_2021_Eur.J.Med.Chem_225_113792 |
| Author(s) : Wichur T , Godyn J , Goral I , Latacz G , Bucki A , Siwek A , Gluch-Lutwin M , Mordyl B , Sniecikowska J , Walczak M , Knez D , Jukic M , Salat K , Gobec S , Kolaczkowski M , Malawska B , Brazzolotto X , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113792 , 2021 |
| Abstract : |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113792 |
| PubMedID: 34530376 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters - Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| Author(s) : Pasieka A , Panek D , Jonczyk J , Godyn J , Szalaj N , Latacz G , Tabor J , Mezeiova E , Chantegreil F , Dias J , Knez D , Lu J , Pi R , Korabecny J , Brazzolotto X , Gobec S , Hofner G , Wanner K , Wieckowska Q , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 218 :113397 , 2021 |
| Abstract : |
| PubMedSearch : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| PubMedID: 33838585 |
| Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783 |
| Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021 |
| Abstract : |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedID: 34461507 |
| Title : Cyanobiphenyls: Novel H(3) receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease - Godyn_2021_Bioorg.Chem_114_105129 |
| Author(s) : Godyn J , Zareba P , aewska D , Stary D , Reiner-Link D , Frank A , Latacz G , Mogilski S , Kaleta M , Doroz-Plonka A , Lubelska A , Honkisz-Orzechowska E , Olejarz-Maciej A , Handzlik J , Stark H , Kiec-Kononowicz K , Malawska B , Bajda M |
| Ref : Bioorg Chem , 114 :105129 , 2021 |
| Abstract : |
| PubMedSearch : Godyn_2021_Bioorg.Chem_114_105129 |
| PubMedID: 34217977 |
| Title : Rational design of new multitarget histamine H(3) receptor ligands as potential candidates for treatment of Alzheimer's disease - Lazewska_2020_Eur.J.Med.Chem_207_112743 |
| Author(s) : Lazewska D , Bajda M , Kaleta M , Zareba P , Doroz-Plonka A , Siwek A , Alachkar A , Mogilski S , Saad A , Kuder K , Olejarz-Maciej A , Godyn J , Stary D , Sudol S , Wiecek M , Latacz G , Walczak M , Handzlik J , Sadek B , Malawska B , Kiec-Kononowicz K |
| Ref : Eur Journal of Medicinal Chemistry , 207 :112743 , 2020 |
| Abstract : |
| PubMedSearch : Lazewska_2020_Eur.J.Med.Chem_207_112743 |
| PubMedID: 32882609 |
| Title : Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease - Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| Author(s) : Wieckowska A , Wichur T , Godyn J , Bucki A , Marcinkowska M , Siwek A , Wieckowski K , Zareba P , Knez D , Gluch-Lutwin M , Kazek G , Latacz G , Mika K , Kolaczkowski M , Korabecny J , Soukup O , Benkova M , Kiec-Kononowicz K , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1195 , 2018 |
| Abstract : |
| PubMedSearch : Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| PubMedID: 29384656 |