| Title : Discovery of new dual butyrylcholinesterase (BuChE) inhibitors and 5-HT(7) receptor antagonists as compounds used to treat Alzheimer's disease symptoms - Kulaga_2025_Biomed.Pharmacother_186_117995 |
| Author(s) : Kulaga D , Drabczyk AK , Zareba P , Jaskowska J , Satala G , Wieckowska A , de Candia M , Purgatorio R , Boguszewska-Czubara A , Sudol-Talaj S , Latacz G , Plazuk D |
| Ref : Biomed Pharmacother , 186 :117995 , 2025 |
| Abstract : |
| PubMedSearch : Kulaga_2025_Biomed.Pharmacother_186_117995 |
| PubMedID: 40106969 |
| Title : Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of Alzheimer's disease - Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| Author(s) : Panek D , Pasieka A , Jonczyk JJ , Gawlinska M , Zareba P , Siwek A , Wolak M , Mordyl B , Gluch-Lutwin M , Latacz G , Brazzolotto X , Chantegreil F , Nachon F , Zdarova Karasova J , Pejchal J , Mzik M , Sestak V , Prchal L , Odvarkova J , Soukup O , Korabecny J , Sorf A , Hamsikova M , Zemanova L , Muckova L , Vanova N , Dryja P , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Angew Chem Int Ed Engl , :e202420510 , 2024 |
| Abstract : |
| PubMedSearch : Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| PubMedID: 39523866 |
| Gene_locus related to this paper: human-BCHE |
| Title : Multitargeting Histamine H(3) Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives - Lazewska_2023_Molecules_28_ |
| Author(s) : Lazewska D , Kaleta M , Zareba P , Godyn J , Dubiel M , Honkisz-Orzechowska E , Doroz-Plonka A , Wieckowska A , Stark H , Kiec-Kononowicz K |
| Ref : Molecules , 28 : , 2023 |
| Abstract : |
| PubMedSearch : Lazewska_2023_Molecules_28_ |
| PubMedID: 36903593 |
| Title : Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, beta-secretase, and amyloid beta aggregation as potential treatment of Alzheimer's disease - Zareba_2023_Eur.J.Med.Chem_261_115832 |
| Author(s) : Zareba P , Latka K , Mazur G , Gryzlo B , Pasieka A , Godyn J , Panek D , Skrzypczak-Wiercioch A , Hofner GC , Latacz G , Maj M , Espargaro A , Sabate R , Jozwiak K , Wanner KT , Salat K , Malawska B , Kulig K , Bajda M |
| Ref : Eur Journal of Medicinal Chemistry , 261 :115832 , 2023 |
| Abstract : |
| PubMedSearch : Zareba_2023_Eur.J.Med.Chem_261_115832 |
| PubMedID: 37837674 |
| Title : Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and beta-amyloid inhibitors for the treatment of Alzheimer's disease - Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| Author(s) : Pasieka A , Panek D , Zareba P , Slugocka E , Gucwa N , Espargaro A , Latacz G , Khan N , Bucki A , Sabate R , Wieckowska A , Malawska B |
| Ref : Bioorganic & Medicinal Chemistry , 88-89 :117333 , 2023 |
| Abstract : |
| PubMedSearch : Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| PubMedID: 37236021 |
| Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135 |
| Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023 |
| Abstract : |
| PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135 |
| PubMedID: 36696766 |
| Gene_locus related to this paper: human-BCHE |
| Title : Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease - Godyn_2022_Molecules_28_ |
| Author(s) : Godyn J , Zareba P , Stary D , Kaleta M , Kuder KJ , Latacz G , Mogilski S , Reiner-Link D , Frank A , Doroz-Plonka A , Olejarz-Maciej A , Sudol-Talaj S , Nolte T , Handzlik J , Stark H , Wieckowska A , Malawska B , Kiec-Kononowicz K , Lazewska D , Bajda M |
| Ref : Molecules , 28 : , 2022 |
| Abstract : |
| PubMedSearch : Godyn_2022_Molecules_28_ |
| PubMedID: 36615435 |
| Title : Cyanobiphenyls: Novel H(3) receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease - Godyn_2021_Bioorg.Chem_114_105129 |
| Author(s) : Godyn J , Zareba P , aewska D , Stary D , Reiner-Link D , Frank A , Latacz G , Mogilski S , Kaleta M , Doroz-Plonka A , Lubelska A , Honkisz-Orzechowska E , Olejarz-Maciej A , Handzlik J , Stark H , Kiec-Kononowicz K , Malawska B , Bajda M |
| Ref : Bioorg Chem , 114 :105129 , 2021 |
| Abstract : |
| PubMedSearch : Godyn_2021_Bioorg.Chem_114_105129 |
| PubMedID: 34217977 |
| Title : Biphenylalkoxyamine Derivatives-Histamine H(3) Receptor Ligands with Butyrylcholinesterase Inhibitory Activity - Lazewska_2021_Molecules_26_ |
| Author(s) : Lazewska D , Zareba P , Godyn J , Doroz-Plonka A , Frank A , Reiner-Link D , Bajda M , Stary D , Mogilski S , Olejarz-Maciej A , Kaleta M , Stark H , Malawska B , Kiec-Kononowicz K |
| Ref : Molecules , 26 : , 2021 |
| Abstract : |
| PubMedSearch : Lazewska_2021_Molecules_26_ |
| PubMedID: 34208297 |
| Title : Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease - Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| Author(s) : Szalaj N , Godyn J , Jonczyk J , Pasieka A , Panek D , Wichur T , Wieckowski K , Zareba P , Bajda M , Pislar A , Malawska B , Sabate R , Wieckowska A |
| Ref : J Enzyme Inhib Med Chem , 35 :1944 , 2020 |
| Abstract : |
| PubMedSearch : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| PubMedID: 33092411 |
| Title : Rational design of new multitarget histamine H(3) receptor ligands as potential candidates for treatment of Alzheimer's disease - Lazewska_2020_Eur.J.Med.Chem_207_112743 |
| Author(s) : Lazewska D , Bajda M , Kaleta M , Zareba P , Doroz-Plonka A , Siwek A , Alachkar A , Mogilski S , Saad A , Kuder K , Olejarz-Maciej A , Godyn J , Stary D , Sudol S , Wiecek M , Latacz G , Walczak M , Handzlik J , Sadek B , Malawska B , Kiec-Kononowicz K |
| Ref : Eur Journal of Medicinal Chemistry , 207 :112743 , 2020 |
| Abstract : |
| PubMedSearch : Lazewska_2020_Eur.J.Med.Chem_207_112743 |
| PubMedID: 32882609 |
| Title : Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands - Bajda_2019_Eur.J.Med.Chem_185_111785 |
| Author(s) : Bajda M , Lazewska D , Godyn J , Zareba P , Kuder K , Hagenow S , Latka K , Stawarska E , Stark H , Kiec-Kononowicz K , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 185 :111785 , 2019 |
| Abstract : |
| PubMedSearch : Bajda_2019_Eur.J.Med.Chem_185_111785 |
| PubMedID: 31669851 |
| Title : Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives - Jonczyk_2019_Bioorg.Chem_90_103084 |
| Author(s) : Jonczyk J , Lodarski K , Staszewski M , Godyn J , Zareba P , Soukup O , Janockova J , Korabecny J , Salat K , Malikowska-Racia N , Hebda M , Szalaj N , Filipek B , Walczynski K , Malawska B , Bajda M |
| Ref : Bioorg Chem , 90 :103084 , 2019 |
| Abstract : |
| PubMedSearch : Jonczyk_2019_Bioorg.Chem_90_103084 |
| PubMedID: 31271942 |
| Title : Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease - Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| Author(s) : Wieckowska A , Wichur T , Godyn J , Bucki A , Marcinkowska M , Siwek A , Wieckowski K , Zareba P , Knez D , Gluch-Lutwin M , Kazek G , Latacz G , Mika K , Kolaczkowski M , Korabecny J , Soukup O , Benkova M , Kiec-Kononowicz K , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1195 , 2018 |
| Abstract : |
| PubMedSearch : Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| PubMedID: 29384656 |
| Title : Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation - Wieckowska_2016_Eur.J.Med.Chem_124_63 |
| Author(s) : Wieckowska A , Kolaczkowski M , Bucki A , Godyn J , Marcinkowska M , Wieckowski K , Zareba P , Siwek A , Kazek G , Gluch-Lutwin M , Mierzejewski P , Bienkowski P , Sienkiewicz-Jarosz H , Knez D , Wichur T , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 124 :63 , 2016 |
| Abstract : |
| PubMedSearch : Wieckowska_2016_Eur.J.Med.Chem_124_63 |
| PubMedID: 27560283 |