LEI105
reversible dual DAGLA/DAGLB inhibitor
General
Type : Pyridine
Chemical_Nomenclature : 1-[6-(4-methylphenyl)-[1,3]oxazolo[4,5-b]pyridin-2-yl]-6-phenylhexan-1-one
Canonical SMILES : CC1=CC=C(C=C1)C2=CC3=C(N=C2)N=C(O3)C(=O)CCCCCC4=CC=CC=C4
InChI : InChI=1S\/C25H24N2O2\/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19\/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3
InChIKey : XDHONXIOZAUYDB-UHFFFAOYSA-N
Other name(s) : LEI-105 || SCHEMBL18240100 || 6-phenyl-1-(6-(p-tolyl)oxazolo[4,5-b]pyridin-2-yl)hexan-1-one
MW : 384.47
Formula : C25H24N2O2
CAS_number :
PubChem : 122390213
UniChem : XDHONXIOZAUYDB-UHFFFAOYSA-N
Target
Families : LEI105 ligand of proteins in family
Lipase_3
References (2)
| Title : Inhibition of diacylglycerol lipase beta modulates lipid and endocannabinoid levels in the ex vivo human placenta - Berger_2023_Front.Endocrinol.(Lausanne)_14_1092024 |
| Author(s) : Berger N , van der Wel T , Hirschmugl B , Baernthaler T , Gindlhuber J , Fawzy N , Eichmann T , Birner-Gruenberger R , Zimmermann R , van der Stelt M , Wadsack C |
| Ref : Front Endocrinol (Lausanne) , 14 :1092024 , 2023 |
| Abstract : |
| PubMedSearch : Berger_2023_Front.Endocrinol.(Lausanne)_14_1092024 |
| PubMedID: 36864832 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons - Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| Author(s) : Baggelaar MP , Chameau PJ , Kantae V , Hummel J , Hsu KL , Janssen F , van der Wel T , Soethoudt M , Deng H , den Dulk H , Allara M , Florea BI , Di Marzo V , Wadman WJ , Kruse CG , Overkleeft HS , Hankemeier T , Werkman TR , Cravatt BF , van der Stelt M |
| Ref : Journal of the American Chemical Society , 137 :8851 , 2015 |
| Abstract : |
| PubMedSearch : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| PubMedID: 26083464 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |