LP1488
hBChE, IC50 = 557 nM; hMAO B, IC50 = 142 nM
General
Type : Chromen, Monoamine-oxidase-inhibitor, Multitarget
Chemical_Nomenclature : (7-[(4-{[(3,4-dimethoxybenzyl)(methyl)amino]methyl}benzyl)oxy]-4-(hydroxymethyl)-2H-chromen-2-one)
Canonical SMILES : CN(Cc1ccc(cc1)COc2ccc3c(c2)OC(=O)C=C3CO)Cc4ccc(c(c4)OC)OC || CN(CC1=CC=C(C=C1)COC2=CC3=C(C=C2)C(=CC(O3)=O)CO)CC4=CC=C(C(=C4)OC)OC
InChI : InChI=1S\/C28H29NO6\/c1-29(16-21-8-11-25(32-2)27(12-21)33-3)15-19-4-6-20(7-5-19)18-34-23-9-10-24-22(17-30)13-28(31)35-26(24)14-23\/h4-14,30H,15-18H2,1-3H3
InChIKey : YBBZJMHQEHMLDB-UHFFFAOYSA-N
Other name(s) : Compound 9 || A1JF0
Target
References (1)
| Title : Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes - Rullo_2026_Eur.J.Med.Chem_316_118961 |
| Author(s) : Rullo M , La Spada G , Brazzolotto X , Marchese S , El Idrissi IG , Miciaccia M , Colella M , Brea JM , Macchia E , Loza MI , Gottinger A , Scilimati A , Perrone MG , Stefanachi A , Binda C , Leonetti F , Pisani L |
| Ref : European Journal of Medicinal Chemistry , :118961 , 2026 |
| Abstract : |
| PubMedSearch : Rullo_2026_Eur.J.Med.Chem_316_118961 |
| PubMedID: |
| Gene_locus related to this paper: human-BCHE |