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Methoxyphenylsulfonamide-indol-thiosemicarbazone-bis(trifluoromethyl)-benzene-cpd5l

IC50 AchE 1.57nM BChE 25.68nM MAO-A 27.23nM Ki AChE 1.43+/-0.44nM Ki BChE 22.53+/-7.70nM

General

Type : Monoamine-oxidase-inhibitor, Trifluoro, Urea derivative, Multitarget, Sulfur Compound, Sulfonamide, Indole

Chemical_Nomenclature : 1-(4-methoxyphenyl)sulfonyl-indol-3-yl-acetaldehyde-thiosemicarbazone-bis(trifluoromethyl)-benzene

Canonical SMILES : COC1=CC=C(C=C1)[S]([N]3C=C(C([H])=NN(C(=NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)S[H])[H])C4=CC=CC=C34)(=O)=O

InChI : InChI=1S\/C25H18F6N4O3S2\/c1-38-19-6-8-20(9-7-19)40(36,37)35-14-15(21-4-2-3-5-22(21)35)13-32-34-23(39)33-18-11-16(24(26,27)28)10-17(12-18)25(29,30)31\/h2-14H,1H3,(H2,33,34,39)\/b32-13+

InChIKey : DLPNQURODLDKRG-JJKQSNDFSA-N

Other name(s) : Compound 5l

MW : 600.553

Formula : C25H18F6N4O3S2

CAS_number :

PubChem :

UniChem : DLPNQURODLDKRG-JJKQSNDFSA-N

Target

Families : Methoxyphenylsulfonamide-indol-thiosemicarbazone-bis(trifluoromethyl)-benzene-cpd5l ligand of proteins in family
ACHE BCHE

Protein :
human-ACHE human-BCHE

References (1)

Title : Synthesis, Anti-Alzheimer Evaluation and In Silico Study of 4-Methoxyphenyl)Sulfonyl Indole Hybrid Thiosemicarbazones - Ghaffar_2025_Arch.Pharm.(Weinheim)_358_e70034
Author(s) : Ghaffar U , Batool Z , Tasleem M , Sadeghian N , Taslimi P , Mali SN , Dahlous KA , Jawarkar RD , Gurav SS , Zhao X , Munir I , Shafiq Z
Ref : Arch Pharm (Weinheim) , 358 :e70034 , 2025
Abstract :
PubMedSearch : Ghaffar_2025_Arch.Pharm.(Weinheim)_358_e70034
PubMedID: 40641099