N-Propargylpyrrolidine-based-Cpd4
IC50(hBChE) = 3.89 microM
General
Type : Pyrrolidine, Naphthalen, Propargyl
Chemical_Nomenclature : N-(2-methoxyethyl)-N-((1-(prop-2-yn-1-yl)pyrrolidin-3-yl)methyl)-2-naphthamide
Canonical SMILES : C3(CN(CCOC)C(C1=CC2=C(C=C1)C=CC=C2)=O)CN(CC3)CC#C
InChI : InChI=1S\/C22H26N2O2\/c1-3-11-23-12-10-18(16-23)17-24(13-14-26-2)22(25)21-9-8-19-6-4-5-7-20(19)15-21\/h1,4-9,15,18H,10-14,16-17H2,2H3
InChIKey : PEDMWTLVZNXASH-UHFFFAOYSA-N
Other name(s) :
Target
Structure :
9R9D
References (1)
| Title : N-Propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| Author(s) : Kosak U , Knez D , Pislar A , Horvat S , Zakelj S , Igert A , Dias J , Nachon F , Brazzolotto X , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111681 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| PubMedID: 40750068 |
| Gene_locus related to this paper: human-BCHE |