Phenolic-deriv-Donecopride-4
AChE IC50 148.6 +/- 34.9 nM; 5-HT4R Ki (nM) 5.1 +/- 1.1
General
Type : Multitarget, 5-HT-receptor-ligand, Derivative of Donepezil, Piperidine
Chemical_Nomenclature :
Canonical SMILES : N1(CCC(CC1)CCC(=O)C2=CC(=C(C=C2OC)N)Cl)CC3=CC=CC(=C3)O
InChI : InChI=1S\/C22H27ClN2O3\/c1-28-22-13-20(24)19(23)12-18(22)21(27)6-5-15-7-9-25(10-8-15)14-16-3-2-4-17(26)11-16\/h2-4,11-13,15,26H,5-10,14,24H2,1H3
InChIKey : MNSSRWVCTXLVHN-UHFFFAOYSA-N
Other name(s) :
Target
Families : Phenolic-deriv-Donecopride-4 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease - Toublet_2019_Molecules_24_ |
| Author(s) : Toublet FX , Lecoutey C , Lalut J , Hatat B , Davis A , Since M , Corvaisier S , Freret T , Sopkova de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Toublet_2019_Molecules_24_ |
| PubMedID: 31370232 |