Tacrine-amino-propyl-carbamoyl-phenyl-propanoate-CpdL3
L3 IC50 nM eeAChE 123.66 +/- 12.01; hAChE 122.34 +/- 21.98; eqBChE 488.00 +/- 173.35 Combined ChE inhibitor and blood-brain barrier (BBB) transporter (L-type amino acid transporter 1 (LAT1))
General
Type : Multitarget, BBB endogenous transporters, Derivative of Tacrine, Acridine, Propionate, Carboxamide
Chemical_Nomenclature : (R)-2-Amino-3-(3-((3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)carbamoyl)phenyl)propanoic acid
Canonical SMILES : C14=C(N=C3C(=C1NCCCNC(C2=CC=CC(=C2)C[C@H](C(O)=O)N)=O)CCCC3)C=CC=C4
InChI : InChI=1S\/C26H30N4O3\/c27-21(26(32)33)16-17-7-5-8-18(15-17)25(31)29-14-6-13-28-24-19-9-1-3-11-22(19)30-23-12-4-2-10-20(23)24\/h1,3,5,7-9,11,15,21H,2,4,6,10,12-14,16,27H2,(H,28,30)(H,29,31)(H,32,33)\/t21-\/m1\/s1
InChIKey : MZHORVQBHJWHMZ-OAQYLSRUSA-N
Other name(s) : Compound L3 || Compound 7c
Target
Families : Tacrine-amino-propyl-carbamoyl-phenyl-propanoate-CpdL3 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : A strategy for improving blood-brain barrier permeability of ChE inhibitors through blood-brain barrier (BBB) transporter - Gao_2026_Eur.J.Med.Chem_307_118687 |
| Author(s) : Gao Z , Hu Y , Zheng N , Wang Q , Xie C , Chen M , Yeasrim S , Wang L , Zhang T , Jia Z , Sun P , Li Y , Xu C , Zhao Q , Wu Y , Chen Y , Sun H |
| Ref : Eur Journal of Medicinal Chemistry , 307 :118687 , 2026 |
| Abstract : |
| PubMedSearch : Gao_2026_Eur.J.Med.Chem_307_118687 |
| PubMedID: 41707280 |