Tacrine-hexyl-pyridinium-CpdC4
C4 IC50 nM eeAChE 11.54 +/- 5.63; hAChE 3.14 +/- 1.75; eqBChE 24.50 +/- 4.78. Combined ChE inhibitor and blood-brain barrier (BBB) transporter (choline transporter)
General
Type : Multitarget, Pyridine, Alkyl linked bis-ligand, BBB endogenous transporters, Pyridinium, Derivative of Tacrine, Acridine
Chemical_Nomenclature : 1-(6-((1,2,3,4-tetrahydroacridin-9-yl)amino)hexyl)pyridin-1-ium
Canonical SMILES : C14=C(N=C3C(=C1NCCCCCC[N ]2=CC=CC=C2)CCCC3)C=CC=C4
InChI : InChI=1S\/C24H30N3\/c1(2-9-17-27-18-10-3-11-19-27)8-16-25-24-20-12-4-6-14-22(20)26-23-15-7-5-13-21(23)24\/h3-4,6,10-12,14,18-19H,1-2,5,7-9,13,15-17H2,(H,25,26)\/q+1
InChIKey : VBXAOKCDKSPRSE-UHFFFAOYSA-N
Other name(s) : Compound C4 || Compound 14d
Target
Families : Tacrine-hexyl-pyridinium-CpdC4 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : A strategy for improving blood-brain barrier permeability of ChE inhibitors through blood-brain barrier (BBB) transporter - Gao_2026_Eur.J.Med.Chem_307_118687 |
| Author(s) : Gao Z , Hu Y , Zheng N , Wang Q , Xie C , Chen M , Yeasrim S , Wang L , Zhang T , Jia Z , Sun P , Li Y , Xu C , Zhao Q , Wu Y , Chen Y , Sun H |
| Ref : Eur Journal of Medicinal Chemistry , 307 :118687 , 2026 |
| Abstract : |
| PubMedSearch : Gao_2026_Eur.J.Med.Chem_307_118687 |
| PubMedID: 41707280 |