Triazole-carbonylpiperidin-diphenylazetidin-2-one-5d-F28
In the structure it is the product Triazole-carbonylpiperidin-diphenylazetidin-2-one-5d-F28
General
Type : Piperidine, Triazol, Azetidin
Chemical_Nomenclature : 4-[(3~{R},4~{S})-2-oxidanylidene-3,4-diphenyl-azetidin-1-yl]piperidine-1-carbaldehyde
Canonical SMILES : c1ccc(cc1)[C@@H]2[C@H](N(C2=O)C3CCN(CC3)C=O)c4ccccc4
InChI : InChI=1S\/C21H22N2O2\/c24-15-22-13-11-18(12-14-22)23-20(17-9-5-2-6-10-17)19(21(23)25)16-7-3-1-4-8-16\/h1-10,15,18-20H,11-14H2\/t19-,20+\/m1\/s1
InChIKey : DIWMCVCOMCANGI-UXHICEINSA-N
Other name(s) :
Target
Families : Triazole-carbonylpiperidin-diphenylazetidin-2-one-5d-F28 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Structure :
8PTC
Protein :
human-MGLL
References (1)
| Title : Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization - Butini_2024_J.Med.Chem__ |
| Author(s) : Butini S , Grether U , Jung KM , Ligresti A , Allara M , Postmus AGJ , Maramai S , Brogi S , Papa A , Carullo G , Sykes D , Veprintsev D , Federico S , Grillo A , Di Guglielmo B , Ramunno A , Stevens AF , Heer D , Lamponi S , Gemma S , Benz J , Di Marzo V , van der Stelt M , Piomelli D , Campiani G |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Butini_2024_J.Med.Chem__ |
| PubMedID: 38241614 |
| Gene_locus related to this paper: human-MGLL |