UB-SCG-51
human sEH IC50 0.4 nM. the arginine salt of UB-SCG-51 designated UB-SCG-74
General
Type : Adamantyl, Urea derivative
Chemical_Nomenclature : 4-[4-[(12-chloro-10-tetracyclo[8.3.1.18,12.02,7]pentadeca-2,4,6-trienyl)carbamoylamino]cyclohexyl]oxybenzoic acid
Canonical SMILES : C1CC(CCC1NC(=O)NC23CC4CC(C2)(CC(C3)C5=CC=CC=C45)Cl)OC6=CC=C(C=C6)C(=O)O
InChI : InChI=1S\/C29H33ClN2O4\/c30-28-13-19-15-29(17-28,16-20(14-28)25-4-2-1-3-24(19)25)32-27(35)31-21-7-11-23(12-8-21)36-22-9-5-18(6-10-22)26(33)34\/h1-6,9-10,19-21,23H,7-8,11-17H2,(H,33,34)(H2,31,32,35)
InChIKey : RMDYCVFIANAQPV-UHFFFAOYSA-N
Other name(s) : 4-[((1r,4r)-4-(3-(9-Chloro-5,6,8,9,10,11-hexahydro-7H-5,9:7,11-dimethanobenzo[9]annulen-7-yl)ureido)cyclohexyl)oxy]benzoic Acid || Compound 22 || CHEMBL5084744 || BDBM50581727
MW : 509
Formula : C29H33ClN2O4
CAS_number :
PubChem : 166635890
UniChem : RMDYCVFIANAQPV-UHFFFAOYSA-N
Target
Families : UB-SCG-51 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (3)
| Title : Novel Soluble Epoxide Hydrolase Inhibitor: Toward Regulatory Preclinical Studies - Jarne-Ferrer_2025_ACS.Pharmacol.Transl.Sci_8_533 |
| Author(s) : Jarne-Ferrer J , Sanchez J , Codony S , Schneider M , Muller CE , Sanfeliu C , Franco R , Vazquez S , Grinan-Ferre C , Pallas M |
| Ref : ACS Pharmacol Transl Sci , 8 :533 , 2025 |
| Abstract : |
| PubMedSearch : Jarne-Ferrer_2025_ACS.Pharmacol.Transl.Sci_8_533 |
| PubMedID: 39974649 |
| Title : Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics - Grinan-Ferre_2023_CNS.Neurosci.Ther__ |
| Author(s) : Grinan-Ferre C , Jarne-Ferrer J , Bellver-Sanchis A , Codony S , Puigoriol-Illamola D , Sanfeliu C , Oh Y , Lee S , Vazquez S , Pallas M |
| Ref : CNS Neurosci Ther , : , 2023 |
| Abstract : |
| PubMedSearch : Grinan-Ferre_2023_CNS.Neurosci.Ther__ |
| PubMedID: 37905690 |
| Title : From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis - Codony_2021_J.Med.Chem__ |
| Author(s) : Codony S , Calvo-Tusell C , Valverde E , Osuna S , Morisseau C , Loza MI , Brea J , Perez C , Rodriguez-Franco MI , Pizarro-Delgado J , Corpas R , Grinan-Ferre C , Pallas M , Sanfeliu C , Vazquez-Carrera M , Hammock BD , Feixas F , Vazquez S |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Codony_2021_J.Med.Chem__ |
| PubMedID: 33945278 |