| Title : Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors - Codony_2022_J.Med.Chem_65_13660 |
| Author(s) : Codony S , Entrena JM , Calvo-Tusell C , Jora B , Gonzalez-Cano R , Osuna S , Corpas R , Morisseau C , Perez B , Barniol-Xicota M , Grinan-Ferre C , Perez C , Rodriguez-Franco MI , Martinez AL , Loza MI , Pallas M , Verhelst SHL , Sanfeliu C , Feixas F , Hammock BD , Brea J , Cobos EJ , Vazquez S |
| Ref : Journal of Medicinal Chemistry , 65 :13660 , 2022 |
| Abstract : |
| PubMedSearch : Codony_2022_J.Med.Chem_65_13660 |
| PubMedID: 36222708 |
| Title : From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis - Codony_2021_J.Med.Chem__ |
| Author(s) : Codony S , Calvo-Tusell C , Valverde E , Osuna S , Morisseau C , Loza MI , Brea J , Perez C , Rodriguez-Franco MI , Pizarro-Delgado J , Corpas R , Grinan-Ferre C , Pallas M , Sanfeliu C , Vazquez-Carrera M , Hammock BD , Feixas F , Vazquez S |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Codony_2021_J.Med.Chem__ |
| PubMedID: 33945278 |
| Title : 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis - Codony_2020_J.Med.Chem_63_9237 |
| Author(s) : Codony S , Pujol E , Pizarro J , Feixas F , Valverde E , Loza MI , Brea JM , Saez E , Oyarzabal J , Pineda-Lucena A , Perez B , Perez C , Rodriguez-Franco MI , Leiva R , Osuna S , Morisseau C , Hammock BD , Vazquez-Carrera M , Vazquez S |
| Ref : Journal of Medicinal Chemistry , 63 :9237 , 2020 |
| Abstract : |
| PubMedSearch : Codony_2020_J.Med.Chem_63_9237 |
| PubMedID: 32787085 |
| Title : New flavonoid - N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer s disease endowed with neurogenic properties - Estrada-Valencia_2019_J.Enzyme.Inhib.Med.Chem_34_712 |
| Author(s) : Estrada-Valencia M , Herrera-Arozamena C , Perez C , Vina D , Morales-Garcia JA , Perez-Castillo A , Ramos E , Romero A , Laurini E , Pricl S , Rodriguez-Franco MI |
| Ref : J Enzyme Inhib Med Chem , 34 :712 , 2019 |
| Abstract : |
| PubMedSearch : Estrada-Valencia_2019_J.Enzyme.Inhib.Med.Chem_34_712 |
| PubMedID: 31852270 |
| Title : Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease - Estrada_2018_Eur.J.Med.Chem_156_534 |
| Author(s) : Estrada Valencia M , Herrera-Arozamena C , de Andres L , Perez C , Morales-Garcia JA , Perez-Castillo A , Ramos E , Romero A , Vina D , Yanez M , Laurini E , Pricl S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 156 :534 , 2018 |
| Abstract : |
| PubMedSearch : Estrada_2018_Eur.J.Med.Chem_156_534 |
| PubMedID: 30025348 |
| Title : Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase\/cholinesterase inhibitors - Reis_2018_Eur.J.Med.Chem_158_781 |
| Author(s) : Reis J , Cagide F , Valencia ME , Teixeira J , Bagetta D , Perez C , Uriarte E , Oliveira PJ , Ortuso F , Alcaro S , Rodriguez-Franco MI , Borges F |
| Ref : Eur Journal of Medicinal Chemistry , 158 :781 , 2018 |
| Abstract : |
| PubMedSearch : Reis_2018_Eur.J.Med.Chem_158_781 |
| PubMedID: 30245401 |
| Title : Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia - Monjas_2017_Eur.J.Med.Chem_130_60 |
| Author(s) : Monjas L , Arce MP , Leon R , Egea J , Perez C , Villarroya M , Lopez MG , Gil C , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 130 :60 , 2017 |
| Abstract : |
| PubMedSearch : Monjas_2017_Eur.J.Med.Chem_130_60 |
| PubMedID: 28242552 |
| Title : New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties - Estrada_2016_Eur.J.Med.Chem_121_376 |
| Author(s) : Estrada M , Herrera-Arozamena C , Perez C , Vina D , Romero A , Morales-Garcia JA , Perez-Castillo A , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 121 :376 , 2016 |
| Abstract : |
| PubMedSearch : Estrada_2016_Eur.J.Med.Chem_121_376 |
| PubMedID: 27267007 |
| Title : New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with sigma-1 agonism and beta-secretase inhibition - Estrada_2016_Future.Med.Chem_8_1191 |
| Author(s) : Estrada M , Perez C , Soriano E , Laurini E , Romano M , Pricl S , Morales-Garcia JA , Perez-Castillo A , Rodriguez-Franco MI |
| Ref : Future Med Chem , 8 :1191 , 2016 |
| Abstract : |
| PubMedSearch : Estrada_2016_Future.Med.Chem_8_1191 |
| PubMedID: 27402296 |
| Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
| Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
| Ref : ChemMedChem , 10 :523 , 2015 |
| Abstract : |
| PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedID: 25537267 |
| Title : N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2- yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor - Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| Author(s) : Bautista-Aguilera OM , Samadi A , Chioua M , Nikolic K , Filipic S , Agbaba D , Soriano E , de Andres L , Rodriguez-Franco MI , Alcaro S , Ramsay RR , Ortuso F , Yanez M , Marco-Contelles J |
| Ref : Journal of Medicinal Chemistry , 57 :10455 , 2014 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| PubMedID: 25418133 |
| Title : New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease - Lopez-Iglesias_2014_J.Med.Chem_57_3773 |
| Author(s) : Lopez-Iglesias B , Perez C , Morales-Garcia JA , Alonso-Gil S , Perez-Castillo A , Romero A , Lopez MG , Villarroya M , Conde S , Rodriguez-Franco MI |
| Ref : Journal of Medicinal Chemistry , 57 :3773 , 2014 |
| Abstract : |
| PubMedSearch : Lopez-Iglesias_2014_J.Med.Chem_57_3773 |
| PubMedID: 24738476 |
| Title : Multipotent, permeable drug ASS234 inhibits Abeta aggregation, possesses antioxidant properties and protects from Abeta-induced apoptosis in vitro - Bolea_2013_Curr.Alzheimer.Res_10_797 |
| Author(s) : Bolea I , Gella A , Monjas L , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Samadi A , Unzeta M |
| Ref : Curr Alzheimer Res , 10 :797 , 2013 |
| Abstract : |
| PubMedSearch : Bolea_2013_Curr.Alzheimer.Res_10_797 |
| PubMedID: 23919774 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2013_Eur.J.Med.Chem_67_64 |
| Author(s) : Samadi A , de la Fuente Revenga M , Perez C , Iriepa I , Moraleda I , Rodriguez-Franco MI , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 67 :64 , 2013 |
| Abstract : |
| PubMedSearch : Samadi_2013_Eur.J.Med.Chem_67_64 |
| PubMedID: 23838422 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase\/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity - Silva_2013_ACS.Chem.Neurosci_4_547 |
| Author(s) : Silva D , Chioua M , Samadi A , Agostinho P , Garcao P , Lajarin-Cuesta R , de los Rios C , Iriepa I , Moraleda I , Gonzalez-Lafuente L , Mendes E , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Carmo Carreiras M |
| Ref : ACS Chem Neurosci , 4 :547 , 2013 |
| Abstract : |
| PubMedSearch : Silva_2013_ACS.Chem.Neurosci_4_547 |
| PubMedID: 23379636 |
| Title : PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice - Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| Author(s) : Lorrio S , Romero A , Gonzalez-Lafuente L , Lajarin-Cuesta R , Martinez-Sanz FJ , Estrada M , Samadi A , Marco-Contelles J , Rodriguez-Franco MI , Villarroya M , Lopez MG , de los Rios C |
| Ref : ACS Chem Neurosci , 4 :1267 , 2013 |
| Abstract : |
| PubMedSearch : Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| PubMedID: 23763493 |
| Title : New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and beta-amyloid-reducing properties - Fernandez-Bachiller_2012_J.Med.Chem_55_1303 |
| Author(s) : Fernandez-Bachiller MI , Perez C , Monjas L , Rademann J , Rodriguez-Franco MI |
| Ref : Journal of Medicinal Chemistry , 55 :1303 , 2012 |
| Abstract : |
| PubMedSearch : Fernandez-Bachiller_2012_J.Med.Chem_55_1303 |
| PubMedID: 22243648 |
| Title : Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling - Samadi_2012_Eur.J.Med.Chem_57C_296 |
| Author(s) : Samadi A , Estrada M , Perez C , Rodriguez-Franco MI , Iriepa I , Moraleda I , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 57C :296 , 2012 |
| Abstract : |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| PubMedID: 23078965 |
| Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661 |
| Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 55 :661 , 2012 |
| Abstract : |
| PubMedSearch : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedID: 22185619 |
| Title : Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Abeta accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease - Antequera_2012_Neurobiol.Dis_46_682 |
| Author(s) : Antequera D , Bolos M , Spuch C , Pascual C , Ferrer I , Fernandez-Bachiller MI , Rodriguez-Franco MI , Carro E |
| Ref : Neurobiol Dis , 46 :682 , 2012 |
| Abstract : |
| PubMedSearch : Antequera_2012_Neurobiol.Dis_46_682 |
| PubMedID: 22426395 |
| Title : N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease - Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| Author(s) : Gonzalez-Munoz GC , Arce MP , Lopez B , Perez C , Romero A , Del Barrio L , Martin-de-Saavedra MD , Egea J , Leon R , Villarroya M , Lopez MG , Garcia AG , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 46 :2224 , 2011 |
| Abstract : |
| PubMedSearch : Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| PubMedID: 21420206 |
| Title : Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties - Fernandez-Bachiller_2010_J.Med.Chem_53_4927 |
| Author(s) : Fernandez-Bachiller MI , Perez C , Gonzalez-Munoz GC , Conde S , Lopez MG , Villarroya M , Garcia AG , Rodriguez-Franco MI |
| Ref : Journal of Medicinal Chemistry , 53 :4927 , 2010 |
| Abstract : |
| PubMedSearch : Fernandez-Bachiller_2010_J.Med.Chem_53_4927 |
| PubMedID: 20545360 |
| Title : Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases - Gonzalez-Munoz_2010_Eur.J.Med.Chem_45_6152 |
| Author(s) : Gonzalez-Munoz GC , Arce MP , Lopez B , Perez C , Villarroya M , Lopez MG , Garcia AG , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 45 :6152 , 2010 |
| Abstract : |
| PubMedSearch : Gonzalez-Munoz_2010_Eur.J.Med.Chem_45_6152 |
| PubMedID: 20926162 |
| Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855 |
| Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D |
| Ref : ChemMedChem , 5 :1855 , 2010 |
| Abstract : |
| PubMedSearch : Viayna_2010_ChemMedChem_5_1855 |
| PubMedID: 20859987 |
| Title : Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease - Arce_2009_J.Med.Chem_52_7249 |
| Author(s) : Arce MP , Rodriguez-Franco MI , Gonzalez-Munoz GC , Perez C , Lopez B , Villarroya M , Lopez MG , Garcia AG , Conde S |
| Ref : Journal of Medicinal Chemistry , 52 :7249 , 2009 |
| Abstract : |
| PubMedSearch : Arce_2009_J.Med.Chem_52_7249 |
| PubMedID: 19856923 |
| Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365 |
| Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009 |
| Abstract : |
| PubMedSearch : Camps_2009_J.Med.Chem_52_5365 |
| PubMedID: 19663388 |
| Title : Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties - Fernandez-Bachiller_2009_ChemMedChem_4_828 |
| Author(s) : Fernandez-Bachiller MI , Perez C , Campillo NE , Paez JA , Gonzalez-Munoz GC , Usan P , Garcia-Palomero E , Lopez MG , Villarroya M , Garcia AG , Martinez A , Rodriguez-Franco MI |
| Ref : ChemMedChem , 4 :828 , 2009 |
| Abstract : |
| PubMedSearch : Fernandez-Bachiller_2009_ChemMedChem_4_828 |
| PubMedID: 19308922 |
| Title : Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties - Rodriguez-Franco_2006_J.Med.Chem_49_459 |
| Author(s) : Rodriguez-Franco MI , Fernandez-Bachiller MI , Perez C , Hernandez-Ledesma B , Bartolome B |
| Ref : Journal of Medicinal Chemistry , 49 :459 , 2006 |
| Abstract : |
| PubMedSearch : Rodriguez-Franco_2006_J.Med.Chem_49_459 |
| PubMedID: 16420031 |
| Title : Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase - Rodriguez-Franco_2005_Bioorg.Med.Chem_13_6795 |
| Author(s) : Rodriguez-Franco MI , Fernandez-Bachiller MI , Perez C , Castro A , Martinez A |
| Ref : Bioorganic & Medicinal Chemistry , 13 :6795 , 2005 |
| Abstract : |
| PubMedSearch : Rodriguez-Franco_2005_Bioorg.Med.Chem_13_6795 |
| PubMedID: 16183292 |
| Title : Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties - Rodriguez-Franco_2000_Arch.Pharm.(Weinheim)_333_118 |
| Author(s) : Rodriguez-Franco MI , Dorronsoro I , Martinez A , Perez C , Badia A , Banos JE |
| Ref : Arch Pharm (Weinheim) , 333 :118 , 2000 |
| Abstract : |
| PubMedSearch : Rodriguez-Franco_2000_Arch.Pharm.(Weinheim)_333_118 |
| PubMedID: 10863795 |