Z-Pro-Prolinal-IC3
General
Type : Benzyloxycarbonyl, Pyrrolidine, Peptide, Cyanide
Chemical_Nomenclature : (2S)-1-[(2S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Canonical SMILES : C1CC(N(C1)C(=O)C2CCCN2C(=O)CCCC3=CC=CC=C3)C#N
InChI : InChI=1S\/C20H25N3O2\/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16\/h1-3,7-8,17-18H,4-6,9-14H2\/t17-,18-\/m0\/s1
InChIKey : SPXFAUXQZWJGCJ-ROUUACIJSA-N
Other name(s) : IC3 || 2P6 || CHEMBL189620 || 4an0 || KYP-2047 || BDBM50155838 || ZINC13584669 || KYP-2047, >=95\% (HPLC)
MW : 339.43
Formula : C20H25N3O2
CAS_number :
PubChem : 11198569
UniChem : SPXFAUXQZWJGCJ-ROUUACIJSA-N
Target
Families : Z-Pro-Prolinal-IC3 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Structure :
4AN0
Protein :
pig-ppce
References (27)
| Title : Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy - Cui_2022_Biochem.Pharmacol_197_114899 |
| Author(s) : Cui H , Norrbacka S , Myohanen TT |
| Ref : Biochemical Pharmacology , 197 :114899 , 2022 |
| Abstract : |
| PubMedSearch : Cui_2022_Biochem.Pharmacol_197_114899 |
| PubMedID: 34968496 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy - Cui_2022_Biochem.Pharmacol_197_114899 |
| Author(s) : Cui H , Norrbacka S , Myohanen TT |
| Ref : Biochemical Pharmacology , 197 :114899 , 2022 |
| Abstract : |
| PubMedSearch : Cui_2022_Biochem.Pharmacol_197_114899 |
| PubMedID: 34968496 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy - Cui_2022_Biochem.Pharmacol_197_114899 |
| Author(s) : Cui H , Norrbacka S , Myohanen TT |
| Ref : Biochemical Pharmacology , 197 :114899 , 2022 |
| Abstract : |
| PubMedSearch : Cui_2022_Biochem.Pharmacol_197_114899 |
| PubMedID: 34968496 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A - Etelainen_2021_Free.Radic.Biol.Med_169_14 |
| Author(s) : Etelainen T , Kulmala V , Svarcbahs R , Jantti M , Myohanen TT |
| Ref : Free Radic Biol Med , 169 :14 , 2021 |
| Abstract : |
| PubMedSearch : Etelainen_2021_Free.Radic.Biol.Med_169_14 |
| PubMedID: 33838285 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A - Etelainen_2021_Free.Radic.Biol.Med_169_14 |
| Author(s) : Etelainen T , Kulmala V , Svarcbahs R , Jantti M , Myohanen TT |
| Ref : Free Radic Biol Med , 169 :14 , 2021 |
| Abstract : |
| PubMedSearch : Etelainen_2021_Free.Radic.Biol.Med_169_14 |
| PubMedID: 33838285 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A - Etelainen_2021_Free.Radic.Biol.Med_169_14 |
| Author(s) : Etelainen T , Kulmala V , Svarcbahs R , Jantti M , Myohanen TT |
| Ref : Free Radic Biol Med , 169 :14 , 2021 |
| Abstract : |
| PubMedSearch : Etelainen_2021_Free.Radic.Biol.Med_169_14 |
| PubMedID: 33838285 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A - Svarcbahs_2020_Pharmacol.Res_151_104558 |
| Author(s) : Svarcbahs R , Jantti M , Kilpelainen T , Julku UH , Urvas L , Kivioja S , Norrbacka S , Myohanen TT |
| Ref : Pharmacol Res , 151 :104558 , 2020 |
| Abstract : |
| PubMedSearch : Svarcbahs_2020_Pharmacol.Res_151_104558 |
| PubMedID: 31759088 |
| Gene_locus related to this paper: human-PREPL |
| Title : The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy - Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| Author(s) : Kilpelainen TP , Hellinen L , Vrijdag J , Yan X , Svarcbahs R , Vellonen KS , Lambeir AM , Huttunen H , Urtti A , Wallen EAA , Myohanen TT |
| Ref : Biomed Pharmacother , 128 :110253 , 2020 |
| Abstract : |
| PubMedSearch : Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| PubMedID: 32447211 |
| Gene_locus related to this paper: human-PREPL , pig-ppce |
| Title : Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A - Svarcbahs_2020_Pharmacol.Res_151_104558 |
| Author(s) : Svarcbahs R , Jantti M , Kilpelainen T , Julku UH , Urvas L , Kivioja S , Norrbacka S , Myohanen TT |
| Ref : Pharmacol Res , 151 :104558 , 2020 |
| Abstract : |
| PubMedSearch : Svarcbahs_2020_Pharmacol.Res_151_104558 |
| PubMedID: 31759088 |
| Gene_locus related to this paper: human-PREPL |
| Title : The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy - Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| Author(s) : Kilpelainen TP , Hellinen L , Vrijdag J , Yan X , Svarcbahs R , Vellonen KS , Lambeir AM , Huttunen H , Urtti A , Wallen EAA , Myohanen TT |
| Ref : Biomed Pharmacother , 128 :110253 , 2020 |
| Abstract : |
| PubMedSearch : Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| PubMedID: 32447211 |
| Gene_locus related to this paper: human-PREPL , pig-ppce |
| Title : Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A - Svarcbahs_2020_Pharmacol.Res_151_104558 |
| Author(s) : Svarcbahs R , Jantti M , Kilpelainen T , Julku UH , Urvas L , Kivioja S , Norrbacka S , Myohanen TT |
| Ref : Pharmacol Res , 151 :104558 , 2020 |
| Abstract : |
| PubMedSearch : Svarcbahs_2020_Pharmacol.Res_151_104558 |
| PubMedID: 31759088 |
| Gene_locus related to this paper: human-PREPL |
| Title : The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy - Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| Author(s) : Kilpelainen TP , Hellinen L , Vrijdag J , Yan X , Svarcbahs R , Vellonen KS , Lambeir AM , Huttunen H , Urtti A , Wallen EAA , Myohanen TT |
| Ref : Biomed Pharmacother , 128 :110253 , 2020 |
| Abstract : |
| PubMedSearch : Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| PubMedID: 32447211 |
| Gene_locus related to this paper: human-PREPL , pig-ppce |
| Title : Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex - Jalkanen_2014_Neurosci.Lett_579_110 |
| Author(s) : Jalkanen AJ , Leikas JV , Forsberg MM |
| Ref : Neuroscience Letters , 579 :110 , 2014 |
| Abstract : |
| PubMedSearch : Jalkanen_2014_Neurosci.Lett_579_110 |
| PubMedID: 25064702 |
| Gene_locus related to this paper: ratno-RPOP |
| Title : Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex - Jalkanen_2014_Neurosci.Lett_579_110 |
| Author(s) : Jalkanen AJ , Leikas JV , Forsberg MM |
| Ref : Neuroscience Letters , 579 :110 , 2014 |
| Abstract : |
| PubMedSearch : Jalkanen_2014_Neurosci.Lett_579_110 |
| PubMedID: 25064702 |
| Gene_locus related to this paper: ratno-RPOP |
| Title : Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex - Jalkanen_2014_Neurosci.Lett_579_110 |
| Author(s) : Jalkanen AJ , Leikas JV , Forsberg MM |
| Ref : Neuroscience Letters , 579 :110 , 2014 |
| Abstract : |
| PubMedSearch : Jalkanen_2014_Neurosci.Lett_579_110 |
| PubMedID: 25064702 |
| Gene_locus related to this paper: ratno-RPOP |
| Title : Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. - Kaszuba_2012_Biochimie_94_1398 |
| Author(s) : Kaszuba K , Rog T , Danne R , Canning P , Fulop V , Juhasz T , Szeltner Z , St Pierre JF , Garcia-Horsman A , Mannisto PT , Karttunen M , Hokkanen J , Bunker A |
| Ref : Biochimie , 94 :1398 , 2012 |
| Abstract : |
| PubMedSearch : Kaszuba_2012_Biochimie_94_1398 |
| PubMedID: 22484394 |
| Gene_locus related to this paper: pig-ppce |
| Title : Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. - Kaszuba_2012_Biochimie_94_1398 |
| Author(s) : Kaszuba K , Rog T , Danne R , Canning P , Fulop V , Juhasz T , Szeltner Z , St Pierre JF , Garcia-Horsman A , Mannisto PT , Karttunen M , Hokkanen J , Bunker A |
| Ref : Biochimie , 94 :1398 , 2012 |
| Abstract : |
| PubMedSearch : Kaszuba_2012_Biochimie_94_1398 |
| PubMedID: 22484394 |
| Gene_locus related to this paper: pig-ppce |
| Title : A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease - Myohanen_2012_Br.J.Pharmacol_166_1097 |
| Author(s) : Myohanen TT , Hannula MJ , Van Elzen R , Gerard M , Van der Veken P , Garcia-Horsman JA , Baekelandt V , Mannisto PT , Lambeir AM |
| Ref : British Journal of Pharmacology , 166 :1097 , 2012 |
| Abstract : |
| PubMedSearch : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| PubMedID: 22233220 |
| Title : A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease - Myohanen_2012_Br.J.Pharmacol_166_1097 |
| Author(s) : Myohanen TT , Hannula MJ , Van Elzen R , Gerard M , Van der Veken P , Garcia-Horsman JA , Baekelandt V , Mannisto PT , Lambeir AM |
| Ref : British Journal of Pharmacology , 166 :1097 , 2012 |
| Abstract : |
| PubMedSearch : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| PubMedID: 22233220 |
| Title : Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. - Kaszuba_2012_Biochimie_94_1398 |
| Author(s) : Kaszuba K , Rog T , Danne R , Canning P , Fulop V , Juhasz T , Szeltner Z , St Pierre JF , Garcia-Horsman A , Mannisto PT , Karttunen M , Hokkanen J , Bunker A |
| Ref : Biochimie , 94 :1398 , 2012 |
| Abstract : |
| PubMedSearch : Kaszuba_2012_Biochimie_94_1398 |
| PubMedID: 22484394 |
| Gene_locus related to this paper: pig-ppce |
| Title : A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease - Myohanen_2012_Br.J.Pharmacol_166_1097 |
| Author(s) : Myohanen TT , Hannula MJ , Van Elzen R , Gerard M , Van der Veken P , Garcia-Horsman JA , Baekelandt V , Mannisto PT , Lambeir AM |
| Ref : British Journal of Pharmacology , 166 :1097 , 2012 |
| Abstract : |
| PubMedSearch : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| PubMedID: 22233220 |
| Title : Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat - Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| Author(s) : Jalkanen AJ , Hakkarainen JJ , Lehtonen M , Venalainen T , Kaariainen TM , Jarho E , Suhonen M , Forsberg MM |
| Ref : Basic Clin Pharmacol Toxicol , 109 :443 , 2011 |
| Abstract : |
| PubMedSearch : Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| PubMedID: 21707925 |
| Gene_locus related to this paper: human-PREP , ratno-RPOP |
| Title : Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat - Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| Author(s) : Jalkanen AJ , Hakkarainen JJ , Lehtonen M , Venalainen T , Kaariainen TM , Jarho E , Suhonen M , Forsberg MM |
| Ref : Basic Clin Pharmacol Toxicol , 109 :443 , 2011 |
| Abstract : |
| PubMedSearch : Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| PubMedID: 21707925 |
| Gene_locus related to this paper: human-PREP , ratno-RPOP |
| Title : Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat - Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| Author(s) : Jalkanen AJ , Hakkarainen JJ , Lehtonen M , Venalainen T , Kaariainen TM , Jarho E , Suhonen M , Forsberg MM |
| Ref : Basic Clin Pharmacol Toxicol , 109 :443 , 2011 |
| Abstract : |
| PubMedSearch : Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| PubMedID: 21707925 |
| Gene_locus related to this paper: human-PREP , ratno-RPOP |
| Title : Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats - Jalkanen_2007_Basic.Clin.Pharmacol.Toxicol_100_132 |
| Author(s) : Jalkanen AJ , Puttonen KA , Venalainen JI , Sinerva V , Mannila A , Ruotsalainen S , Jarho EM , Wallen EA , Mannisto PT |
| Ref : Basic Clin Pharmacol Toxicol , 100 :132 , 2007 |
| Abstract : |
| PubMedSearch : Jalkanen_2007_Basic.Clin.Pharmacol.Toxicol_100_132 |
| PubMedID: 17244263 |
| Gene_locus related to this paper: ratno-RPOP |
| Title : Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats - Jalkanen_2007_Basic.Clin.Pharmacol.Toxicol_100_132 |
| Author(s) : Jalkanen AJ , Puttonen KA , Venalainen JI , Sinerva V , Mannila A , Ruotsalainen S , Jarho EM , Wallen EA , Mannisto PT |
| Ref : Basic Clin Pharmacol Toxicol , 100 :132 , 2007 |
| Abstract : |
| PubMedSearch : Jalkanen_2007_Basic.Clin.Pharmacol.Toxicol_100_132 |
| PubMedID: 17244263 |
| Gene_locus related to this paper: ratno-RPOP |
| Title : Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats - Jalkanen_2007_Basic.Clin.Pharmacol.Toxicol_100_132 |
| Author(s) : Jalkanen AJ , Puttonen KA , Venalainen JI , Sinerva V , Mannila A , Ruotsalainen S , Jarho EM , Wallen EA , Mannisto PT |
| Ref : Basic Clin Pharmacol Toxicol , 100 :132 , 2007 |
| Abstract : |
| PubMedSearch : Jalkanen_2007_Basic.Clin.Pharmacol.Toxicol_100_132 |
| PubMedID: 17244263 |
| Gene_locus related to this paper: ratno-RPOP |