ZTL-11
General
Type : GSK-3 kinase inhibitor, Carboxamide, Multitarget, Triazol, Indole, Cyclopropyl, beta-carboline
Chemical_Nomenclature : 1-(Cyclopropanecarboxamido)-N-((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-9H-pyrido[3,4-b]indole-7-carboxamide
Canonical SMILES : C14=C([N]C2=C1[C]=[C]N=C2[N]C(=O)[C]3CC3)[C]=C([C]=[C]4)C([N]CC5=[C][N](N=N5)CC6=[C][C]=[C][C]=C6F)=O
InChI : InChI=1S\/C26H22FN7O2\/c27-21-4-2-1-3-17(21)13-34-14-18(32-33-34)12-29-25(35)16-7-8-19-20-9-10-28-24(23(20)30-22(19)11-16)31-26(36)15-5-6-15\/h1-4,7-11,14-15,30H,5-6,12-13H2,(H,29,35)(H,28,31,36)
InChIKey : YJUAZZHNQVXWDO-UHFFFAOYSA-N
Other name(s) : ZTL-11
Target
Families : ZTL-11 ligand of proteins in family
ACHE
References (1)
| Title : Discovery of novel beta-carboline-1,2,3-triazole hybrids as AChE\/GSK-3beta dual inhibitors for Alzheimer's disease treatment - Liu_2022_Bioorg.Chem_129_106168 |
| Author(s) : Liu W , Tian L , Wu L , Chen H , Wang N , Liu X , Zhao C , Wu Z , Jiang X , Wu Q , Xu Z , Zhao Q |
| Ref : Bioorg Chem , 129 :106168 , 2022 |
| Abstract : |
| PubMedSearch : Liu_2022_Bioorg.Chem_129_106168 |
| PubMedID: 36191431 |