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Inhibitor Report for: Choline

Product of hydrolysis of acetylcholine by cholinesterases.A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.


General
Type Natural, Trimethylammonium
Chemical_Nomenclature [2-hydroxyethyl]trimethylammonium
Canonical SMILES C[N+](C)(C)CCO
InChI InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
InChIKey OEYIOHPDSNJKLS-UHFFFAOYSA-N
Other name(s) Bilineurine ; Hepacholine ; Hormocline ; Biocolina ; Biocoline ; Cholinum ; Lipotril ; Neocolina ; Paresan ; CHT ; CHEBI:15354 ; CHEMBL920 ; SCHEMBL3142 ; ZINC3079337 ; DB00122
________________________________________________________________________________________________
MW|104.2
Formula|C5H14NO
CAS_number|62-49-7
PubChem|305
UniChem|OEYIOHPDSNJKLS-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Choline

Target
Families | Choline ligand of proteins in family: ACHE, BCHE
Stucture | 2 structures: 2HA3, 1P0M
Protein | mouse-ACHE, human-BCHE

References:
Search PubMed for references concerning: Choline

2 more
    Title: Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.
    Lockridge O
    Ref: Pharmacol Ther, 47:35, 1990 : PubMed

            

    Title: Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide
    Whittaker M, Britten JJ
    Ref: Hum Hered, 31:242, 1981 : PubMed

            

    Title: The activity of various esterase inhibitors towards atypical human serum cholinesterase
    Kalow W, Davies R0
    Ref: Biochemical Pharmacology, 1:183, 1958 : PubMed

            


human-BCHE
MutationKiKsiIc50SubstrateConditionPaper
D70G - - 59 mM   Lockridge_1990_Pharmacol.Ther_47_35
WT - - 30 mM   Lockridge_1990_Pharmacol.Ther_47_35

WT Kinetics
Kinetic parametersKiKsiIc50SubstrateConditionsPapers
human-BCHE--30 mM  Lockridge_1990_Pharmacol.Ther_47_35