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Inhibitor Report for: JF635

Azetidine-substituted fluorescent compound ligand of Halo-Tag. Si-rhodamine JF635 JF635-HaloTag ligand


General
Type Fluorescent Probe, HaloTag-ligand, Azetidin, Carboxamide, Benzofuran
Chemical_Nomenclature N-[2-[2-(6-chlorohexoxy)ethoxy]ethyl]-3',7'-bis(3-fluoroazetidin-1-yl)-5',5'-dimethyl-1-oxospiro[2-benzofuran-3,10'-benzo[b][1]benzosiline]-5-carboxamide
Canonical SMILES C[Si]1(C2=C(C=CC(=C2)N3CC(C3)F)C4(C5=C1C=C(C=C5)N6CC(C6)F)C7=C(C=CC(=C7)C(=O)NCCOCCOCCCCCCCl)C(=O)O4)C
InChI InChI=1S/C39H46ClF2N3O5Si/c1-51(2)35-20-29(44-22-27(41)23-44)8-11-32(35)39(33-12-9-30(21-36(33)51)45-24-28(42)25-45)34-19-26(7-10-31(34)38(47)50-39)37(46)43-14-16-49-18-17-48-15-6-4-3-5-13-40/h7-12,19-21,27-28H,3-6,13-18,22-25H2,1-2H3,(H,43,46)
InChIKey FWPLRLFVYPWZHQ-UHFFFAOYSA-N
Other name(s) PUJ ; Janelia Fluor 635
________________________________________________________________________________________________
MW|738.3
Formula|C39H46ClF2N3O5Si
CAS_number|
PubChem|147582007
UniChem|FWPLRLFVYPWZHQ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | JF635 ligand of proteins in family: Haloalkane_dehalogenase-HLD2
Stucture | 1 structure: 6U2M: Crystal structure of a HaloTag-based calcium indicator, HaloCaMP V2, bound to JF635
Protein | rhoso-halo1

References:
Search PubMed for references concerning: JF635
    Title: The HaloTag as a general scaffold for far-red tunable chemigenetic indicators
    Deo C, Abdelfattah AS, Bhargava HK, Berro AJ, Falco N, Farrants H, Moeyaert B, Chupanova M, Lavis LD, Schreiter ER
    Ref: Nat Chemical Biology, 17:718, 2021 : PubMed

            

    Title: Accurate measurement of fast endocytic recycling kinetics in real time
    Jonker CTH, Deo C, Zager PJ, Tkachuk AN, Weinstein AM, Rodriguez-Boulan E, Lavis LD, Schreiner R
    Ref: Journal of Cell Science, 133:, 2020 : PubMed