(S,S)-(-)-bis(10)-hupyridone
two fragments of huperzine associated by a linker
General
Type : Derivative of Huperzine, Quinoline, Alkyl linked bis-ligand
Chemical_Nomenclature : (5S)-5-[10-[[(5S)-2-oxo-5,6,7,8-tetrahydro-1H-quinolin-5-yl]amino]decylamino]-5,6,7,8-tetrahydro-1H-quinolin-2-one
Canonical SMILES : C1CC(C2=C(C1)NC(=O)C=C2)NCCCCCCCCCCNC3CCCC4=C3C=CC(=O)N4
InChI : InChI=1S\/C28H42N4O2\/c33-27-17-15-21-23(11-9-13-25(21)31-27)29-19-7-5-3-1-2-4-6-8-20-30-24-12-10-14-26-22(24)16-18-28(34)32-26\/h15-18,23-24,29-30H,1-14,19-20H2,(H,31,33)(H,32,34)\/t23-,24-\/m0\/s1
InChIKey : CKFAWHBPSZAYLS-ZEQRLZLVSA-N
Other name(s) : CHEMBL483090 || BDBM10439
MW : 466.65
Formula : C28H42N4O2
CAS_number :
PubChem : 445974
UniChem : CKFAWHBPSZAYLS-ZEQRLZLVSA-N
-(-)-bis(10)-hupyridone.gif)
Target
Families : (S,S)-(-)-bis(10)-hupyridone ligand of proteins in family
ACHE
Structure :
1H22
Protein :
torca-ACHE
References (2)
| Title : Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity - Wong_2003_J.Am.Chem.Soc_125_363 |
| Author(s) : Wong DM , Greenblatt HM , Dvir H , Carlier PR , Han YF , Pang YP , Silman I , Sussman JL |
| Ref : J Am Chem Soc , 125 :363 , 2003 |
| Abstract : |
| PubMedSearch : Wong_2003_J.Am.Chem.Soc_125_363 |
| PubMedID: 12517147 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease - Fink_1995_J.Med.Chem_38_3645 |
| Author(s) : Fink DM , Bores GM , Effland RC , Huger FP , Kurys BE , Rush DK , Selk DE |
| Ref : Journal of Medicinal Chemistry , 38 :3645 , 1995 |
| Abstract : |
| PubMedSearch : Fink_1995_J.Med.Chem_38_3645 |
| PubMedID: 7658452 |