(R)-Tacrine(10)-Hupyridone

Fragment of huperzine associated by a linker with tacrine

General

Type : Derivative of Huperzine, Derivative of Tacrine, Quinoline, Alkyl linked bis-ligand

Chemical_Nomenclature : (5R)-5-[10-(1,2,3,4-tetrahydroacridin-9-ylamino)decylamino]-5,6,7,8-tetrahydro-1H-quinolin-2-one

Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCCCCCNC4CCCC5=C4C=CC(=O)N5

InChI : InChI=1S\/C32H44N4O\/c37-31-21-20-24-27(18-13-19-28(24)36-31)33-22-11-5-3-1-2-4-6-12-23-34-32-25-14-7-9-16-29(25)35-30-17-10-8-15-26(30)32\/h7,9,14,16,20-21,27,33H,1-6,8,10-13,15,17-19,22-23H2,(H,34,35)(H,36,37)\/t27-\/m1\/s1

InChIKey : ROTFGKJJMRTWBD-HHHXNRCGSA-N

Other name(s) :


MW : 500.71

Formula : C32H44N4O

CAS_number :

PubChem : 5326966

UniChem : ROTFGKJJMRTWBD-HHHXNRCGSA-N

Target

Families : (R)-Tacrine(10)-Hupyridone ligand of proteins in family
ACHE

Protein :
torca-ACHE

References (3)

Title : Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease - Xuan_2021_ACS.Chem.Neurosci_12_2462
Author(s) : Xuan Z , Gu X , Yan S , Xie Y , Zhou Y , Zhang H , Jin H , Hu S , Mak MSH , Zhou D , Tsim KWK , Carlier PR , Han Y , Cui W
Ref : ACS Chem Neurosci , 12 :2462 , 2021
PubMedID: 34156230

Title : Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase - Haviv_2005_J.Am.Chem.Soc_127_11029
Author(s) : Haviv H , Wong DM , Greenblatt HM , Carlier PR , Pang YP , Silman I , Sussman JL
Ref : Journal of the American Chemical Society , 127 :11029 , 2005
PubMedID: 16076210
Gene_locus related to this paper: torca-ACHE

Title : Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease - Fink_1995_J.Med.Chem_38_3645
Author(s) : Fink DM , Bores GM , Effland RC , Huger FP , Kurys BE , Rush DK , Selk DE
Ref : Journal of Medicinal Chemistry , 38 :3645 , 1995
PubMedID: 7658452