IC50 0.0826 microM (AChE) and 0.0156 microM (BChE)
Type : Acridine, Derivative of Tacrine, Salicylic, Alkyl linked bis-ligand
Chemical_Nomenclature :
Canonical SMILES : [C]2=[C]C1=NC4=C(C(=C1[C]=[C]2)[N]CCCCCCCCN=[C]C3=[C][C]=[C][C]=C3[O])CCCC4
InChI : InChI=1S\/C28H35N3O\/c32-27-18-10-5-13-22(27)21-29-19-11-3-1-2-4-12-20-30-28-23-14-6-8-16-25(23)31-26-17-9-7-15-24(26)28\/h5-6,8,10,13-14,16,18,21,32H,1-4,7,9,11-12,15,17,19-20H2,(H,30,31)
InChIKey : INQWNLSYQXSCDQ-UHFFFAOYSA-N
Other name(s) :
Families : 10c-Salicylimine-Tacrine ligand of proteins in family
BCHE
Protein :
human-BCHE
Title : Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease - Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Grishchenko MV , Lushchekina SV , Astakhova TY , Serebryakova OG , Timokhina EN , Zhilina EF , Shchegolkov EV , Ulitko MV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ |
Ref : Int J Mol Sci , 24 :2285 , 2023 |
Abstract : |
PubMedSearch : Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
PubMedID: 36768608 |