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Inhibitor Report for: Lalistat-2

Apart from Lysosomal acid lipase human-LIPA, Lalistat-1 and -2 also inhibit major cytosolic lipid hydrolases responsible for lipid degradation in primary cells at neutral pH through off-target effects (ATGL not alpha/beta hydrolas; HSL hormone sensitive lipase); MGL Monoglyceride lipase). Lalistat also impairs Mycobacterium tuberculosis growth by targeting hydolases LipR Rv3084 Rv1984c Rv0183


General
Type Piperidine, Lipase inhibitor, Sulfur Compound, Thiadiazol
Chemical_Nomenclature (4-piperidin-1-yl-1,2,5-thiadiazol-3-yl) piperidine-1-carboxylate
Canonical SMILES C1CCN(CC1)C2=NSN=C2OC(=O)N3CCCCC3
InChI InChI=1S/C13H20N4O2S/c18-13(17-9-5-2-6-10-17)19-12-11(14-20-15-12)16-7-3-1-4-8-16/h1-10H2
InChIKey PNYYVHOTXOEBEV-UHFFFAOYSA-N
Other name(s) CHEMBL1085857 ; 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate ; Lalistat 2 ; SCHEMBL17078239 ; BDBM50318691
________________________________________________________________________________________________
MW|296.38
Formula|C13H20N4O2S
CAS_number|1234569-09-5
PubChem|46867138
UniChem|PNYYVHOTXOEBEV-UHFFFAOYSA-N
IUPHAR|
Wikipedia|


References:
Search PubMed for references concerning: Lalistat-2

8 more
    Title: Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
    Bradic I, Kuentzel KB, Honeder S, Grabner GF, Vujic N, Zimmermann R, Birner-Gruenberger R, Kratky D
    Ref: Mol Metab, :101510, 2022 : PubMed

            

    Title: Loss of Function of Lysosomal Acid Lipase (LAL) Profoundly Impacts Osteoblastogenesis and Increases Fracture Risk in Humans
    Helderman RC, Whitney DG, Duta-Mare M, Akhmetshina A, Vujic N, Jayapalan S, Nyman JS, Misra BB, Rosen CJ and Rendina-Ruedy E <2 more author(s)>
    Ref: Bone, :115946, 2021 : PubMed

            

    Title: Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease
    Thoen RU, Longo L, Neto SC, Alvares-da-Silva MR
    Ref: Clin Res Hepatol Gastroenterol, 45:101638, 2021 : PubMed