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Inhibitor Report for: Vildagliptin

General
Type Drug, Pyrrolidine, Gliptin, Adamantyl
Chemical_Nomenclature (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
Canonical SMILES C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N
InChI InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
InChIKey SYOKIDBDQMKNDQ-XWTIBIIYSA-N
Other name(s) NVP-LAF237 ; Galvus ; Xiliarx ; Jalra
________________________________________________________________________________________________
MW|303.39
Formula|C17H25N3O2
CAS_number|274901-16-5
PubChem|6918537
UniChem|SYOKIDBDQMKNDQ-XWTIBIIYSA-N
IUPHAR|6310
Wikipedia|Vildagliptin

Target
Families | Vildagliptin ligand of proteins in family: DPP4N_Peptidase_S9
Stucture | 2 structures: 6B1E, 3W2T
Protein | human-DPP4

References:
Search PubMed for references concerning: Vildagliptin

5 more
    Title: Vildagliptin-Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9-Specific Lead
    Benramdane S, De Loose J, Beyens O, Van Rymenant Y, Vliegen G, Augustyns K, De Winter H, De Meester I, Van der Veken P
    Ref: ChemMedChem, :e202200097, 2022 : PubMed

            

    Title: A Comparative Study of the Binding Modes of Recently Launched Dipeptidyl Peptidase IV Inhibitors in the Active Site
    Nabeno M, Akahoshi F, Kishida H, Miyaguchi I, Tanaka Y, Ishii S, Kadowaki T
    Ref: Biochemical & Biophysical Research Communications, 434:191, 2013 : PubMed

            

    Title: Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes
    Gupta R, Walunj SS, Tokala RK, Parsa KV, Singh SK, Pal M
    Ref: Curr Drug Targets, 10:71, 2009 : PubMed