Heidelberg_2000_Nature_406_477

Reference

Title : DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae - Heidelberg_2000_Nature_406_477
Author(s) : Heidelberg JF , Eisen JA , Nelson WC , Clayton RA , Gwinn ML , Dodson RJ , Haft DH , Hickey EK , Peterson JD , Umayam L , Gill SR , Nelson KE , Read TD , Tettelin H , Richardson D , Ermolaeva MD , Vamathevan J , Bass S , Qin H , Dragoi I , Sellers P , McDonald L , Utterback T , Fleishmann RD , Nierman WC , White O , Salzberg SL , Smith HO , Colwell RR , Mekalanos JJ , Venter JC , Fraser CM
Ref : Nature , 406 :477 , 2000
Abstract :

Here we determine the complete genomic sequence of the gram negative, gamma-Proteobacterium Vibrio cholerae El Tor N16961 to be 4,033,460 base pairs (bp). The genome consists of two circular chromosomes of 2,961,146 bp and 1,072,314 bp that together encode 3,885 open reading frames. The vast majority of recognizable genes for essential cell functions (such as DNA replication, transcription, translation and cell-wall biosynthesis) and pathogenicity (for example, toxins, surface antigens and adhesins) are located on the large chromosome. In contrast, the small chromosome contains a larger fraction (59%) of hypothetical genes compared with the large chromosome (42%), and also contains many more genes that appear to have origins other than the gamma-Proteobacteria. The small chromosome also carries a gene capture system (the integron island) and host 'addiction' genes that are typically found on plasmids; thus, the small chromosome may have originally been a megaplasmid that was captured by an ancestral Vibrio species. The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.

PubMedSearch : Heidelberg_2000_Nature_406_477
PubMedID: 10952301
Gene_locus related to this paper: vibch-rtxAABH , vibch-lipas , vibch-VC0135 , vibch-VC0522 , vibch-VC1418 , vibch-VC1725 , vibch-VC1974 , vibch-VC1986 , vibch-VC2097 , vibch-VC2432 , vibch-VC2610 , vibch-VC2718 , vibch-VCA0063 , vibch-VCA0092 , vibch-VCA0490 , vibch-VCA0688 , vibch-VCA0754 , vibch-VCA0863 , vibch-y1892 , vibch-y2276

Related information

Gene_locus vibch-rtxAABH    vibch-lipas    vibch-VC0135    vibch-VC0522    vibch-VC1418    vibch-VC1725    vibch-VC1974    vibch-VC1986    vibch-VC2097    vibch-VC2432    vibch-VC2610    vibch-VC2718    vibch-VCA0063    vibch-VCA0092    vibch-VCA0490    vibch-VCA0688    vibch-VCA0754    vibch-VCA0863    vibch-y1892    vibch-y2276
Gene_locus_frgt vibch-rtxAABH    vibch-lipas    vibch-VC0135    vibch-VC0522    vibch-VC1418    vibch-VC1725    vibch-VC1974    vibch-VC1986    vibch-VC2097    vibch-VC2432    vibch-VC2610    vibch-VC2718    vibch-VCA0063    vibch-VCA0092    vibch-VCA0490    vibch-VCA0688    vibch-VCA0754    vibch-VCA0863    vibch-y1892    vibch-y2276    vibch-VC0600

Citations formats

Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM (2000)
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
Nature 406 :477

Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM (2000)
Nature 406 :477