Vibrio cholerae alpha/beta hydrolase domain of MARTX. Phosphatidylinositol-3-phosphate-specific phospholipase A1
Large protein (5200 aa) Multifunctional-autoprocessing repeats-in-toxin: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain). One of the liberated protein is an alpha\/beta hydrolase which has a phosphatidylinositol-3-phosphate-specific phospholipase A1 activity which inhibits autophagy and endosomal trafficking as shown by Agarwal et al.<\/A> || Vibrio cholerae
Family : 6_AlphaBeta_hydrolase
Block : X
Position in NCBI Life Tree : Vibrio cholerae O1 biovar El Tor str. N16961
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Vibrionales N E > Vibrionaceae N E > Vibrio N E > Vibrio cholerae N E > Vibrio cholerae O1 N E > Vibrio cholerae O1 biovar El Tor N E > Vibrio cholerae O1 biovar El Tor str. N16961 N ESGNEKPKENV AIENDGTPPR DKESLSPLTR FLNNELYGDK EARRKIGEIT QTLLDHAVEK GESQKITLQG EAGRLTGYYH QGTAPSEGET SSPSGKVVLF LHGSGSSAEE QASAIRNHYQ KQGIDMLAVN LRGYGESDGG PSEKGLYQDA RTMFNYLVND KGIDPSNIII HGYSMGGPIA ADLARYAAQN GQAVSGLLLD RPMPSMTKAI TAHEVANPAG IVGAIAKAVN GQFSVEKNLE GLPKETSILL LTDNEGLGNE GEKLRTKLTA SGYNVTGEQT FYGHEASNRL MSQYADQIVS GLSSSASVDE DLDQQGLDTT STKDQGISNK NDHLQVVDSK EAL
| Title : Bacterial RTX toxins and host immunity - Ahmad_2021_Curr.Opin.Infect.Dis_34_187 |
| Author(s) : Ahmad JN , Sebo P |
| Ref : Curr Opin Infect Dis , 34 :187 , 2021 |
| Abstract : |
| PubMedSearch : Ahmad_2021_Curr.Opin.Infect.Dis_34_187 |
| PubMedID: 33899753 |
| Gene_locus related to this paper: vibch-rtxAABH |
| Title : The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapse - Woida_2020_Sci.Signal_13_ |
| Author(s) : Woida PJ , Satchell KJF |
| Ref : Sci Signal , 13 : , 2020 |
| Abstract : |
| PubMedSearch : Woida_2020_Sci.Signal_13_ |
| PubMedID: 31937566 |
| Gene_locus related to this paper: vibch-rtxAABH |
| Title : Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity - Agarwal_2015_Nat.Commun_6_8745 |
| Author(s) : Agarwal S , Kim H , Chan RB , Williamson R , Cho W , Paolo GD , Satchell KJ |
| Ref : Nat Commun , 6 :8745 , 2015 |
| Abstract : |
| PubMedSearch : Agarwal_2015_Nat.Commun_6_8745 |
| PubMedID: 26498860 |
| Gene_locus related to this paper: vibch-rtxAABH |
| Title : Comparative genome analysis of Vibrio vulnificus, a marine pathogen - Chen_2003_Genome.Res_13_2577 |
| Author(s) : Chen CY , Wu KM , Chang YC , Chang CH , Tsai HC , Liao TL , Liu YM , Chen HJ , Shen AB , Li JC , Su TL , Shao CP , Lee CT , Hor LI , Tsai SF |
| Ref : Genome Res , 13 :2577 , 2003 |
| Abstract : |
| PubMedSearch : Chen_2003_Genome.Res_13_2577 |
| PubMedID: 14656965 |
| Gene_locus related to this paper: vibch-rtxAABH , vibvu-VV10137 , vibvu-VV10171 , vibvu-VV10305 , vibvu-VV10607 , vibvu-VV10627 , vibvu-VV10862 , vibvu-VV11137 , vibvu-VV11321 , vibvu-VV12133 , vibvu-VV12349 , vibvu-VV13171 , vibvu-VV20101 , vibvu-VV20395 , vibvu-VV20739 , vibvu-VV20795 , vibvu-VV20967 , vibvu-VV20970 , vibvu-VV21216 , vibvu-yk72 , vibvy-q7mff9 , vibvy-q7mfv5 , vibvy-q7mn77 , vibvy-y856 |
| Title : DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae - Heidelberg_2000_Nature_406_477 |
| Author(s) : Heidelberg JF , Eisen JA , Nelson WC , Clayton RA , Gwinn ML , Dodson RJ , Haft DH , Hickey EK , Peterson JD , Umayam L , Gill SR , Nelson KE , Read TD , Tettelin H , Richardson D , Ermolaeva MD , Vamathevan J , Bass S , Qin H , Dragoi I , Sellers P , McDonald L , Utterback T , Fleishmann RD , Nierman WC , White O , Salzberg SL , Smith HO , Colwell RR , Mekalanos JJ , Venter JC , Fraser CM |
| Ref : Nature , 406 :477 , 2000 |
| Abstract : |
| PubMedSearch : Heidelberg_2000_Nature_406_477 |
| PubMedID: 10952301 |
| Gene_locus related to this paper: vibch-rtxAABH , vibch-lipas , vibch-VC0135 , vibch-VC0522 , vibch-VC1418 , vibch-VC1725 , vibch-VC1974 , vibch-VC1986 , vibch-VC2097 , vibch-VC2432 , vibch-VC2610 , vibch-VC2718 , vibch-VCA0063 , vibch-VCA0092 , vibch-VCA0490 , vibch-VCA0688 , vibch-VCA0754 , vibch-VCA0863 , vibch-y1892 , vibch-y2276 |