GM415
General
Type : Oxime, Pyridine-aldoxime
Chemical_Nomenclature :
Canonical SMILES : C1(=C(N=C(C=C1)CCCCCN2CC3=C(CC2)C=C(C(=C3)OC)OC)C=NO)O
InChI : InChI=1S\/C22H29N3O4\/c1-28-21-12-16-9-11-25(15-17(16)13-22(21)29-2)10-5-3-4-6-18-7-8-20(26)19(24-18)14-23-27\/h7-8,12-14,26-27H,3-6,9-11,15H2,1-2H3
InChIKey : IMDWRYLXDURLRG-UHFFFAOYSA-N
Other name(s) :
Target
Structure : No structure
Families : No family
References (3)
| Title : Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning - Zorbaz_2020_ACS.Chem.Neurosci__ |
| Author(s) : Zorbaz T , Misetic P , Probst N , Zunec S , Zandona A , Mendas G , Micek V , Macek Hrvat N , Katalinic M , Braiki A , Jean L , Renard PY , Gabelica Markovic V , Kovarik Z |
| Ref : ACS Chem Neurosci , : , 2020 |
| Abstract : |
| PubMedSearch : Zorbaz_2020_ACS.Chem.Neurosci__ |
| PubMedID: 32105443 |
| Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675 |
| Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY |
| Ref : Chemistry , 24 :9675 , 2018 |
| Abstract : |
| PubMedSearch : Zorbaz_2018_Chemistry_24_9675 |
| PubMedID: 29672968 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection - Pashirova_2018_J.Control.Release_290_102 |
| Author(s) : Pashirova TN , Braiki A , Zueva IV , Petrov KA , Babaev VM , Burilova EA , Samarkina DA , Rizvanov IK , Souto EB , Jean L , Renard PY , Masson P , Zakharova LY , Sinyashin OG |
| Ref : J Control Release , 290 :102 , 2018 |
| Abstract : |
| PubMedSearch : Pashirova_2018_J.Control.Release_290_102 |
| PubMedID: 30308259 |