| Title : Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties - Pont_2024_Pharmaceutics_16_ |
| Author(s) : Pont C , Sampietro A , Perez-Areales FJ , Cristiano N , Albalat A , Perez B , Bartolini M , De Simone A , Andrisano V , Barenys M , Teixido E , Sabate R , Loza MI , Brea J , Munoz-Torrero D |
| Ref : Pharmaceutics , 16 : , 2024 |
| Abstract : |
| PubMedSearch : Pont_2024_Pharmaceutics_16_ |
| PubMedID: 39204327 |
| Title : Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease - Codony_2022_J.Med.Chem_65_4909 |
| Author(s) : Codony S , Pont C , Grinan-Ferre C , Di Pede-Mattatelli A , Calvo-Tusell C , Feixas F , Osuna S , Jarne-Ferrer J , Naldi M , Bartolini M , Loza MI , Brea J , Perez B , Bartra C , Sanfeliu C , Juarez-Jimenez J , Morisseau C , Hammock BD , Pallas M , Vazquez S , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 65 :4909 , 2022 |
| Abstract : |
| PubMedSearch : Codony_2022_J.Med.Chem_65_4909 |
| PubMedID: 35271276 |
| Title : Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors - Codony_2022_J.Med.Chem_65_13660 |
| Author(s) : Codony S , Entrena JM , Calvo-Tusell C , Jora B , Gonzalez-Cano R , Osuna S , Corpas R , Morisseau C , Perez B , Barniol-Xicota M , Grinan-Ferre C , Perez C , Rodriguez-Franco MI , Martinez AL , Loza MI , Pallas M , Verhelst SHL , Sanfeliu C , Feixas F , Hammock BD , Brea J , Cobos EJ , Vazquez S |
| Ref : Journal of Medicinal Chemistry , 65 :13660 , 2022 |
| Abstract : |
| PubMedSearch : Codony_2022_J.Med.Chem_65_13660 |
| PubMedID: 36222708 |
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects - Pont_2021_Eur.J.Med.Chem_225_113779 |
| Author(s) : Pont C , Ginex T , Grinan-Ferre C , Scheiner M , Mattellone A , Martinez N , Arce EM , Soriano-Fernandez Y , Naldi M , De Simone A , Barenys M , Gomez-Catalan J , Perez B , Sabate R , Andrisano V , Loza MI , Brea J , Bartolini M , Bolognesi ML , Decker M , Pallas M , Luque FJ , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113779 , 2021 |
| Abstract : |
| PubMedSearch : Pont_2021_Eur.J.Med.Chem_225_113779 |
| PubMedID: 34418785 |
| Title : Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease - Grinan-Ferre_2020_Neurotherapeutics__ |
| Author(s) : Grinan-Ferre C , Codony S , Pujol E , Yang J , Leiva R , Escolano C , Puigoriol-Illamola D , Companys-Alemany J , Corpas R , Sanfeliu C , Perez B , Loza MI , Brea J , Morisseau C , Hammock BD , Vazquez S , Pallas M , Galdeano C |
| Ref : Neurotherapeutics , : , 2020 |
| Abstract : |
| PubMedSearch : Grinan-Ferre_2020_Neurotherapeutics__ |
| PubMedID: 32488482 |
| Title : 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis - Codony_2020_J.Med.Chem_63_9237 |
| Author(s) : Codony S , Pujol E , Pizarro J , Feixas F , Valverde E , Loza MI , Brea JM , Saez E , Oyarzabal J , Pineda-Lucena A , Perez B , Perez C , Rodriguez-Franco MI , Leiva R , Osuna S , Morisseau C , Hammock BD , Vazquez-Carrera M , Vazquez S |
| Ref : Journal of Medicinal Chemistry , 63 :9237 , 2020 |
| Abstract : |
| PubMedSearch : Codony_2020_J.Med.Chem_63_9237 |
| PubMedID: 32787085 |
| Title : Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 - Perez-Areales_2020_J.Med.Chem_63_9360 |
| Author(s) : Perez-Areales FJ , Garrido M , Aso E , Bartolini M , De Simone A , Espargaro A , Ginex T , Sabate R , Perez B , Andrisano V , Puigoriol-Illamola D , Pallas M , Luque FJ , Loza MI , Brea J , Ferrer I , Ciruela F , Messeguer A , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 63 :9360 , 2020 |
| Abstract : |
| PubMedSearch : Perez-Areales_2020_J.Med.Chem_63_9360 |
| PubMedID: 32706255 |
| Title : Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor - Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| Author(s) : Cieslikiewicz-Bouet M , Naldi M , Bartolini M , Perez B , Servent D , Jean L , Araoz R , Renard PY |
| Ref : Biochemical Pharmacology , :114010 , 2020 |
| Abstract : |
| PubMedSearch : Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| PubMedID: 32360492 |
| Title : A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors - Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| Author(s) : Perez-Areales FJ , Turcu AL , Barniol-Xicota M , Pont C , Pivetta D , Espargaro A , Bartolini M , De Simone A , Andrisano V , Perez B , Sabate R , Sureda FX , Vazquez S , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 180 :613 , 2019 |
| Abstract : |
| PubMedSearch : Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| PubMedID: 31351393 |
| Title : Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice - Relat_2018_Int.J.Mol.Sci_19_ |
| Author(s) : Relat J , Come J , Perez B , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Clos MV |
| Ref : Int J Mol Sci , 19 : , 2018 |
| Abstract : |
| PubMedSearch : Relat_2018_Int.J.Mol.Sci_19_ |
| PubMedID: 30181440 |
| Title : Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation - Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| Author(s) : Relat J , Perez B , Camps P , Munoz-Torrero D , Badia A , Victoria Clos M |
| Ref : Basic Clin Pharmacol Toxicol , 122 :94 , 2018 |
| Abstract : |
| PubMedSearch : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| PubMedID: 28724203 |
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675 |
| Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY |
| Ref : Chemistry , 24 :9675 , 2018 |
| Abstract : |
| PubMedSearch : Zorbaz_2018_Chemistry_24_9675 |
| PubMedID: 29672968 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease - Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behav Pharmacol , 28 :124 , 2017 |
| Abstract : |
| PubMedSearch : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| PubMedID: 28125507 |
| Title : Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids - Perez-Areales_2017_Future.Med.Chem_9_965 |
| Author(s) : Perez-Areales FJ , Betari N , Viayna A , Pont C , Espargaro A , Bartolini M , De Simone A , Rinaldi Alvarenga JF , Perez B , Sabate R , Lamuela-Raventos RM , Andrisano V , Luque FJ , Munoz-Torrero D |
| Ref : Future Med Chem , 9 :965 , 2017 |
| Abstract : |
| PubMedSearch : Perez-Areales_2017_Future.Med.Chem_9_965 |
| PubMedID: 28632395 |
| Title : Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity - Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| Author(s) : Di Pietro O , Vicente-Garcia E , Taylor MC , Berenguer D , Viayna E , Lanzoni A , Sola I , Sayago H , Riera C , Fisa R , Clos MV , Perez B , Kelly JM , Lavilla R , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 105 :120 , 2015 |
| Abstract : |
| PubMedSearch : Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| PubMedID: 26479031 |
| Title : Dodecenyl succinylated alginate as a novel material for encapsulation and hyperactivation of lipases - Falkeborg_2015_Carbohydr.Polym_133_194 |
| Author(s) : Falkeborg M , Paitaid P , Shu AN , Perez B , Guo Z |
| Ref : Carbohydr Polym , 133 :194 , 2015 |
| Abstract : |
| PubMedSearch : Falkeborg_2015_Carbohydr.Polym_133_194 |
| PubMedID: 26344272 |
| Title : AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice - Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behavioural Brain Research , 286 :97 , 2015 |
| Abstract : |
| PubMedSearch : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| PubMedID: 25732954 |
| Title : Characterization and mechanism insight of accelerated catalytic promiscuity of Sulfolobus tokodaii (ST0779) peptidase for aldol addition reaction - Li_2015_Appl.Microbiol.Biotechnol_99_9625 |
| Author(s) : Li R , Perez B , Jian H , Jensen MM , Gao R , Dong M , Glasius M , Guo Z |
| Ref : Applied Microbiology & Biotechnology , 99 :9625 , 2015 |
| Abstract : |
| PubMedSearch : Li_2015_Appl.Microbiol.Biotechnol_99_9625 |
| PubMedID: 26169629 |
| Gene_locus related to this paper: sulto-ST0779 |
| Title : Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity - Sola_2015_Bioorg.Med.Chem_23_5156 |
| Author(s) : Sola I , Castella S , Viayna E , Galdeano C , Taylor MC , Gbedema SY , Perez B , Clos MV , Jones DC , Fairlamb AH , Wright CW , Kelly JM , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 23 :5156 , 2015 |
| Abstract : |
| PubMedSearch : Sola_2015_Bioorg.Med.Chem_23_5156 |
| PubMedID: 25678015 |
| Title : Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines - Sola_2014_Bioorg.Med.Chem.Lett_24_5435 |
| Author(s) : Sola I , Artigas A , Taylor MC , Gbedema SY , Perez B , Clos MV , Wright CW , Kelly JM , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 24 :5435 , 2014 |
| Abstract : |
| PubMedSearch : Sola_2014_Bioorg.Med.Chem.Lett_24_5435 |
| PubMedID: 25454267 |
| Title : Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies - Di Pietro_2014_Eur.J.Med.Chem_84C_107 |
| Author(s) : Di Pietro O , Perez-Areales FJ , Juarez-Jimenez J , Espargaro A , Clos MV , Perez B , Lavilla R , Sabate R , Luque FJ , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 84C :107 , 2014 |
| Abstract : |
| PubMedSearch : Di Pietro_2014_Eur.J.Med.Chem_84C_107 |
| PubMedID: 25016233 |
| Title : Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties - Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| Author(s) : Perez-Areales FJ , Di Pietro O , Espargaro A , Vallverdu-Queralt A , Galdeano C , Ragusa IM , Viayna E , Guillou C , Clos MV , Perez B , Sabate R , Lamuela-Raventos RM , Luque FJ , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 22 :5298 , 2014 |
| Abstract : |
| PubMedSearch : Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| PubMedID: 25156301 |
| Title : Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents - Viayna_2014_J.Med.Chem_57_2549 |
| Author(s) : Viayna E , Sola I , Bartolini M , De Simone A , Tapia-Rojas C , Serrano FG , Sabate R , Juarez-Jimenez J , Perez B , Luque FJ , Andrisano V , Clos MV , Inestrosa NC , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 57 :2549 , 2014 |
| Abstract : |
| PubMedSearch : Viayna_2014_J.Med.Chem_57_2549 |
| PubMedID: 24568372 |
| Title : Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide - Pera_2013_PLoS.One_8_e74344 |
| Author(s) : Pera M , Camps P , Munoz-Torrero D , Perez B , Badia A , Clos Guillen MV |
| Ref : PLoS ONE , 8 :e74344 , 2013 |
| Abstract : |
| PubMedSearch : Pera_2013_PLoS.One_8_e74344 |
| PubMedID: 24086337 |
| Title : Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer's Disease in Triple Transgenic Mice (3xTg-AD) - Ratia_2013_Neurodegener.Dis_11_129 |
| Author(s) : Ratia M , Gimenez-Llort L , Camps P , Munoz-Torrero D , Perez B , Clos MV , Badia A |
| Ref : Neurodegener Dis , 11 :129 , 2013 |
| Abstract : |
| PubMedSearch : Ratia_2013_Neurodegener.Dis_11_129 |
| PubMedID: 22626981 |
| Title : 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies - Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| Author(s) : Di Pietro O , Viayna E , Vicente-Garcia E , Bartolini M , Ramon R , Juarez-Jimenez J , Clos MV , Perez B , Andrisano V , Luque FJ , Lavilla R , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 73C :141 , 2013 |
| Abstract : |
| PubMedSearch : Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| PubMedID: 24389509 |
| Title : The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions - Chahinian_2002_Biochemistry_41_13725 |
| Author(s) : Chahinian H , Bezzine S , Ferrato F , Ivanova MG , Perez B , Lowe ME , Carriere F |
| Ref : Biochemistry , 41 :13725 , 2002 |
| Abstract : |
| PubMedSearch : Chahinian_2002_Biochemistry_41_13725 |
| PubMedID: 12427035 |