9R3C
Name : Human Butyrylcholinesterase in complex with N-([(3S)-1-benzylpiperidin-3-yl]methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide
Revelation date : 30-Jul-2025
Family : BCHE
Gene_locus : human-BCHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Brazzolotto, X., Kosac, U., Gobec, S., Nachon, F.
Ligand : Inhibitor CHEMBL4105611 Ligand in structure: Ligplot
References (3)
| Title : Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| Author(s) : Kosak U , Knez D , Benetik SF , Sokolov PM , Pislar A , Horvat S , Stojan J , Lv B , Zhang W , Wang Y , Wang Q , Igert A , Dias J , Nachon F , Brazzolotto X , Sun H , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111670 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| PubMedID: 40712769 |
| Gene_locus related to this paper: human-BCHE |
| Title : Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| Author(s) : Kosak U , Knez D , Benetik SF , Sokolov PM , Pislar A , Horvat S , Stojan J , Lv B , Zhang W , Wang Y , Wang Q , Igert A , Dias J , Nachon F , Brazzolotto X , Sun H , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111670 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| PubMedID: 40712769 |
| Gene_locus related to this paper: human-BCHE |
| Title : Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| Author(s) : Kosak U , Knez D , Benetik SF , Sokolov PM , Pislar A , Horvat S , Stojan J , Lv B , Zhang W , Wang Y , Wang Q , Igert A , Dias J , Nachon F , Brazzolotto X , Sun H , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111670 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| PubMedID: 40712769 |
| Gene_locus related to this paper: human-BCHE |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 9R3C Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 9R3C Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 9R3C Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 9R3C 3D, interactive encyclopedia of proteins - PROTEOPEDIA server