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Structure Report for: 7P1P

Name|Crystal structure of human acetylcholinesterase in complexe with (E)-3-hydroxy-6-(3-(4-(4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)butyl)-1H-1,2,3-triazol-1-yl)propyl)picolinaldehyde oxime
Revelation date|29-Dec-2021
Family|ACHE: there are 538 genes in this family, 315 structure(s)
Gene_locus|human-ACHE
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Ophelie Da Silva.,Jose, Dias.,Florian, Nachon.
Ligand|Inhibitor: 7P1P-4IX Ligand in structure: Ligplot Reactivator: 7P1P-4IX Ligand in structure: Ligplot


Reference

    Title: A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
    Da Silva O, Probst N, Landry C, Hanak AS, Warnault P, Coisne C, Calas AG, Gosselet F, Courageux C and Dias J <7 more author(s)>
    Ref: Journal of Medicinal Chemistry, :, 2022 : PubMed

            



Representative scheme of ACHE structure and an image from PDBsum server



Databases

PDB-Sum7P1P Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP7P1P Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP7P1P Structural Classification Of Protein - SCOP server
PROTEOPEDIA7p1p 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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