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Structure Report for: 7PKV

Name|Structure of the human Wnt deacylase Notum in complex with ARUK3000223 Compound 7b
Revelation date|07-Sep-2022
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 143 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Ruza, R.,Zhao, Y.,Fish, P.,Jones, E.Y.
Ligand|Inhibitor: ARUK3000223 Ligand in structure: Ligplot


    Title: Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
    Willis NJ, Mahy W, Sipthorp J, Zhao Y, Woodward HL, Atkinson BN, Bayle ED, Svensson F, Frew S and Fish PV <14 more author(s)>
    Ref: Journal of Medicinal Chemistry, 65:7212, 2022 : PubMed


    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed


Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

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PDB-Sum7PKV Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP7PKV Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP7PKV Structural Classification Of Protein - SCOP server
PROTEOPEDIA7pkv 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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